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GSE184859 Brusatol inhibits proliferation and invasion of glioblastoma by down-regulating the expression of ECM1
Contributors : Cai Lin ; Dai Zhang'an ; Lu XiangheSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBrusatol (Bru), a Chinese herbal extract, has a variety of anti-tumor effects. However, little is known regarding its role and underlying mechanism in glioblastoma cells. Here, we found that Bru could inhibit the proliferation of glioblastoma cells in vivo and in vitro. Besides, it also had an inhibitory effect on human primary glioblastoma cells. In order to further study the underlying mechanism of Bru ’s action on GBM, we performed RNA sequencing array on GBM cells treated by Bru wit...
Source: GEO: Gene Expression Omnibus - December 31, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE54338 Expression of microRNAs in rat kidney treated with a carcinogenic dose of Aristolochic Acid
Contributors : Zhiguang Li ; Taichun Qin ; Michael Hackenberg ; Jian Yan ; Kejian Wang ; Yuan Gao ; Lirong Yu ; Leming Shi ; Tao ChenSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Rattus norvegicusAristolochic Acid (AA), a natural component of Aristolochia plants found in a variety of herbal remedies and health supplements, is classified as a group 1 carcinogen by the International Agency for Research on Cancer. In order to search for miRNA regulation in AA-induced carcinogenesis, we treated rats with 10 mg/kg AA and vehicle control for 12 weeks and eight kidney samples (4 for the treatment ...
Source: GEO: Gene Expression Omnibus - January 15, 2015 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Rattus norvegicus Source Type: research