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Specialty: Genetics & Stem Cells
Source: GEO: Gene Expression Omnibus
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Total 163 results found since Jan 2013.
GSE155257 Analysis of human stroke brain tissue resected during decompressive craniectomy or stroke-ectomy surgery
Conclusions: Dysregulated miRNAs detected in our study could be regarded as potential candidates for biomarkers and/or targets for therapeutic intervention. The obtained data will serve for better understanding of the molecular basis of stroke and provide valuable information for the future functional studies in the experimental models of stroke.
Source: GEO: Gene Expression Omnibus - July 29, 2020 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
GSE203399 Study of the DNA methylation in the stroke outcome: an Epigenome-Wide Association Study
Contributors : Israel Fern ández-Cadenas ; Joan Montaner ; Natalia CullellSeries Type : Methylation profiling by arrayOrganism : Homo sapiensBackground and Purpose The neurological course after stroke is highly variable and is determined by demographic, clinical, and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in neurological changes after stroke. Methods We performed a three-stage epigenome-wide association study (EWAS) to evaluate DNA methylation associated with the difference between the National Institutes of Health Stroke Scale (NIHSS) at baseline and at disc...
Source: GEO: Gene Expression Omnibus - May 20, 2022 Category: Genetics & Stem Cells Tags: Methylation profiling by array Homo sapiens Source Type: research
GSE138805 Transcriptomic changes of mouse monocytes and macrophages after ischemic stroke
Contributors : Yejie Shi ; Jun ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBlood monocytes/macrophages infiltrate the brain after ischemic stroke and critically influence brain injury and regeneration. We investigated stroke-induced transcriptomic changes of monocytes/macrophages by RNA sequencing profiling, using a mouse model of permanent focal cerebral ischemia. Compared to non-ischemic conditions, brain ischemia induced only moderate genomic changes in blood monocytes, but triggered robust genomic reprogramming in monocytes/macrophages invading the brain. Surprisingly, fun...
Source: GEO: Gene Expression Omnibus - November 7, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE234052 The transcriptional landscape of pericytes in acute ischemic stroke
This study identifies temporal transcriptional changes in the acute phase of ischemic stroke that reflect the early response of pericytes to the ischemic insult and its secondary consequences and may constitute potential future therapeutic targets.
Source: GEO: Gene Expression Omnibus - June 29, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE158313 Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade III
Contributors : Katarzyna Winek ; Sebastian Lobentanzer ; Hermona SoreqSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensAfter ischemic stroke, the brain initiates intensive communication with the immune system, and acetylcholine contributes to this process. Stroke triggers peripheral immunosuppression leading to increased susceptibility to infections; and post-stroke pneumonia is linked with poor stroke outcome, but the responsible processes are yet unknown. We discovered a “change of guards” where microRNA levels decreased but small transfer RNA fragments (tRFs) accumulated in ...
Source: GEO: Gene Expression Omnibus - December 31, 2020 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
GSE158312 Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade II
Contributors : Katarzyna Winek ; Sebastian Lobentanzer ; Hermona SoreqSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAfter ischemic stroke, the brain initiates intensive communication with the immune system, and acetylcholine contributes to this process. Stroke triggers peripheral immunosuppression leading to increased susceptibility to infections; and post-stroke pneumonia is linked with poor stroke outcome, but the responsible processes are yet unknown. We discovered a “change of guards” where microRNA levels decreased but small transfer RNA fragments (tRFs) accumulated in post...
Source: GEO: Gene Expression Omnibus - December 31, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE158311 Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade I
Contributors : Katarzyna Winek ; Sebastian Lobentanzer ; Hermona SoreqSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAfter ischemic stroke, the brain initiates intensive communication with the immune system, and acetylcholine contributes to this process. Stroke triggers peripheral immunosuppression leading to increased susceptibility to infections; and post-stroke pneumonia is linked with poor stroke outcome, but the responsible processes are yet unknown. We discovered a “change of guards” where microRNA levels decreased but small transfer RNA fragments (tRFs) accumulated in post...
Source: GEO: Gene Expression Omnibus - December 31, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE189432 Stroke induces disease-specific myeloid cells in the brain parenchyma and pia
Contributors : Carolin Beuker ; David Schafflick ; Jan-Kolja Strecker ; Michael Heming ; Gerd Meyer zu H örste ; Jens MinnerupSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammation triggers secondary brain damage after stroke. The meninges and other CNS border compartments serve as invasion sites for leukocyte influx into the brain thus promoting tissue damage after stroke. However, the post-ischemic immune response of border compartments compared to brain parenchyma remains poorly characterized .Here, we deeply characterize tissue-resident leukocytes in meninges and brain pare...
Source: GEO: Gene Expression Omnibus - November 26, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE163752 RNAseq dataset of murine NVU cells post ischemic stroke isolated using the SGD method from the same starting material.
Contributors : Devraj Kavi ; G ünther StefanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe blood-brain barier (BBB) function is impaired in several neurological diseases such as stroke. To better study the BBB dysfunction in stroke and to identify novel therapeutic targets, a detailed analysis of the neurovascular unit (NVU) cells that together regulate the BBB function is needed. To this end, we isolated the NVU cells EC, PC, AC, MG post stroke in mice using our newly developed SGD (Spitzer, Gu érit, Devraj) method from the same starting material followed by RNA sequencing. Ce...
Source: GEO: Gene Expression Omnibus - July 20, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE66724 Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis with no increased bleeding risk
Contributors : Mikel Allende ; José HermidaSeries Type : Expression profiling by arrayOrganism : Homo sapiensAtrial fibrillation (AF) is a major risk factor for cardioembolic stroke. Anticoagulant drugs are effective in preventing AF-related stroke. However, the high frequency of anticoagulant-associated major bleeding is a major concern particularly when antiplatelet treatment is simultaneously administered. Here, microarray analysis in peripheral blood cells in eight patients with AF and stroke and eight AF subjects without stroke identified a stroke related gene expression pattern. HSPA1B, which encodes for heat-shock ...
Source: GEO: Gene Expression Omnibus - April 1, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE128623 The spinal transcriptome after cortical stroke – In search of molecular factors regulating spontaneous recovery in the spinal cord
In this study, we provide insights into the molecular changes in the spinal cord tissue after large ischemic cortical injury in adult female mice, with a focus on factors that might influence the re-innervation process by contralesional corticospinal neurons. We mapped the area of cervical grey matter re-innervation by sprouting contralesional corticospinal axons after unilateral photothrombotic stroke of the motor cortex in mice using anterograde tracing. The mRNA profile of this re-innervation area was analyzed using whole-genome sequencing to identify differentially expressed genes at selected time points during the rec...
Source: GEO: Gene Expression Omnibus - April 30, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE162072 Transcriptome profiling following focal ischemic stroke in female rats
Contributors : Mimmi Rehnstr öm ; Simona D Frederiksen ; Saema Ansar ; Lars EdvinssonSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusBackground. Women account for 60% of all stroke deaths and are more often permanently disabled than men, despite their higher observed stroke incidence. Considering the clinical population affected by stroke, an obvious drawback is that many pre-clinical and clinical studies only investigate young males. To improve therapeutic translation from bench to bedside, we believe that it is advantageous to include both sexes in experimental models of stroke. The aims of this s...
Source: GEO: Gene Expression Omnibus - November 25, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research
GSE116878 Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke
Contributors : Joonki Kim ; Thiruma V ArumugamSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntermittent fasting is previously reported to exhibit neuroprotection against experimental ischemic stroke. However, the detailed understanding of protection mechanisms are lacking. By observing the overall transcriptomic changes in each timepoint of ischemic stroke would benefit the understanding of underlying active pathways and mechanisms. Here, we conduct experimental MCAO ischemic stroke on mice exposed to different daily intermittent fasting method to compare not only among the ischemi...
Source: GEO: Gene Expression Omnibus - July 11, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE167593 Single-Cell RNA-Seq reveals cellualr heterogeneity and gene expression difference between ischemic and hemorrhagic stroke brain
Contributors : Xiaojing Shi ; Jixian Wang ; Yaohui TangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCluster analysis using nonlinear dimensionality reduction ([tSNE]) revealed the differences in global gene expression profiles of healthy and injured striatum, and identified clusters of cells with unique genetic signatures in both ischemic brain and hemorrhagic brain. Genes with p-value
Source: GEO: Gene Expression Omnibus - February 27, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE168934 The critical role of chondroitin sulfate proteoglycan interactions with receptor PTP σ in the inhibition of neural repair after stroke
Contributors : Yu Luo ; Jerry Silver ; Frank Huang ; Zhen YouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe used RNAseq to compare transcriptome of peri-infarct cortex in stroke mice that received vehicle or ISP treatment (which blocks the PTPsigma receptor signaling) at 14 days post stroke. The purpose of this project is to identify genes that are differentially expressed in control stroke mice and ISP treated stroke mice that might mediated the behavioral improvement in ISP treated stroke mice.
Source: GEO: Gene Expression Omnibus - March 16, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
