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Differential effect of gold nanoparticles on cerebrovascular function and biomechanical properties
This study provides the first evidence that GNPs affect the structure and function of the cerebrovasculature, which may be important for their development and use in biomedical applications.
Source: Physiological Reports - August 22, 2023 Category: Physiology Authors: Ryan D. Hunt, Omid Sedighi, Wayne M. Clark, Amber L. Doiron, Marilyn  J. Cipolla Tags: ORIGINAL ARTICLE Source Type: research

Short high ‐fat diet interferes with the physiological maturation of the late adolescent mouse heart
This study suggests that even a short period of high fat intake during late adolescence hinders maturation of the heart and causes physiological changes that may have an impact on the cardiac health in adulthood. AbstractDietary fats are essential for cardiac function. The metabolites of fats known as fatty acids provide most of the energy for cardiac tissue, serve as building blocks for membranes and regulate important signaling cascades. Despite their importance, excess fat intake can cause cardiac dysfunction. The detrimental effects of high ‐fat diet (HFD) on cardiac health are widely investigated in long‐term stud...
Source: Physiological Reports - July 7, 2020 Category: Physiology Authors: Heidi Hynynen, Maija Mutikainen, Nikolay Naumenko, Anastasia Shakirzyanova, Tomi Tuomainen, Pasi Tavi Tags: ORIGINAL RESEARCH Source Type: research

Influence of dual ‐specificity protein phosphatase 5 on mechanical properties of rat cerebral and renal arterioles
In this study, we found that KO ofDusp5 did not alter body weights, kidney and brain weights, plasma glucose, and HbA1C levels. The expression of pERK is higher in the nucleus of primary VSMC isolated fromDusp5 KO rats.Dusp5 KO rats exhibited eutrophic vascular hypotrophy with smaller intracerebral parenchymal arterioles and renal interlobular arterioles without changing the wall ‐to‐lumen ratios. These arterioles fromDusp5 KO rats displayed higher myogenic tones, better distensibility, greater compliance, and less stiffness compared with arterioles from WT control rats. VSMC ofDusp5 KO rats exhibited a stronger contra...
Source: Physiological Reports - January 19, 2020 Category: Physiology Authors: Huawei Zhang, Chao Zhang, Yedan Liu, Wenjun Gao, Shaoxun Wang, Xing Fang, Ya Guo, Man Li, Ruen Liu, Richard J. Roman, Peng Sun, Fan Fan Tags: ORIGINAL RESEARCH Source Type: research