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Decreased carbon shunting from glucose toward oxidative metabolism in diet‐induced ketotic rat brain
This study reveals that there is a significant contribution of ketone bodies to oxidative metabolism and GABA in diet‐induced ketosis. We propose that this represents a fundamental mechanism of neuroprotection under pathological conditions. We investigated glucose versus ketone bodies contributions to citric acid (CAC) intermediates and brain amino acids. We found decreased carbon shunting from glucose toward oxidative metabolism in diet‐induced ketotic rat brain, whereas the carbon shunting from ketone bodies toward oxidative metabolism increased, toward gamma‐aminobutyric acid (GABA). The partitioning of ketone bod...
Source: Journal of Neurochemistry - November 10, 2014 Category: Neuroscience Authors: Yifan Zhang, Shenghui Zhang, Isaac Marin‐Valencia, Michelle A. Puchowicz Tags: Original Article Source Type: research

Progesterone and allopregnanolone improve stroke outcome in male mice via distinct mechanisms but neither promotes neurogenesis
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - November 7, 2014 Category: Neuroscience Authors: Rona J. Lee, Joon K. Kim, Diana Chao, Lisa Kuo, Adheip Mally, Megan E. McClean, Heather E. Pemberton, Andrew R. Wilmington, Jennifer Wong, Sean P. Murphy Tags: Short Communication Source Type: research

Combination therapy with transductive anti ‐death FNK protein and FK506 ameliorates brain damage with focal transient ischemia in rat
AbstractMany practical therapies have been explored as clinical applications for ischemic cerebral infarction; however, most are still insufficient to treat acute stroke. We show here a potential combination therapy in a rat focal ischemic model to improve neurological symptoms as well as to reduce infarct volumes at the maximum level. We applied protein transduction technology using artificial anti ‐death FNK protein fused with a protein‐transduction‐domain peptide (PTD‐FNK). When PTD‐FNK was administrated 1 hr after initiating ischemia followed by the administration of an immunosuppressant FK506 with a 30‐min...
Source: Journal of Neurochemistry - August 4, 2010 Category: Neuroscience Authors: Ken ‐ichiro Katsura, Kumiko Takahashi, Sadamitsu Asoh, Megumi Watanabe, Makoto Sakurazawa, Ikuroh Ohsawa, Takashi Mori, Hironaka Igarashi, Seiji Ohkubo, Yasuo Katayama, Shigeo Ohta Source Type: research

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