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Source: Journal of Neurochemistry
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Total 123 results found since Jan 2013.
HSPB8 over ‐expression prevents disruption of blood–brain barrier by promoting autophagic flux after cerebral ischemia/reperfusion injury
This study focused on the effect of intracerebroventricular (i.c.v) delivery of lenti ‐HSPB8 virus against neurological injury in a rat model of cerebral I/R and explored the underlying mechanism. We found that lentivirus i.c.v injection‐induced HSPB8 over‐expression strongly alleviated infarct volume, improved neurobehavioral outcomes, and reduced brain edema in rat middle cer ebral artery occlusion/reperfusion (MCAO/R) model. Concomitantly, HSPB8 over‐expression noticeably prevented blood–brain barrier (BBB) disruption after cerebral I/R injury as indicated by the reduction in Evans blue leakage and IgG detecti...
Source: Journal of Neurochemistry - December 13, 2018 Category: Neuroscience Authors: Fazhao Li,
Binbin Yang,
Ting Li,
Xiyu Gong,
Fangfang Zhou,
Zhiping Hu Tags: Original Article Source Type: research
Nicotine and electronic cigarette (E ‐Cig) exposure decreases brain glucose utilization in ischemic stroke
Journal of Neurochemistry, EarlyView.
Source: Journal of Neurochemistry - October 19, 2018 Category: Neuroscience Authors: Ali E. Sifat,
Bhuvaneshwar Vaidya,
Mohammad A. Kaisar,
Luca Cucullo,
Thomas J. Abbruscato Source Type: research
Nicotine & electronic cigarette (E ‐Cig) exposure decreases brain glucose utilization in ischemic stroke
Journal of Neurochemistry,Volume 0, Issue ja, -Not available-.
Source: Journal of Neurochemistry - July 31, 2018 Category: Neuroscience Authors: Ali E. Sifat
,
Bhuvaneshwar Vaidya
,
Mohammad A. Kaisar
,
Luca Cucullo
,
Thomas J. Abbruscato Source Type: research
G5G2.5 core ‐shell tecto‐dendrimer specifically targets reactive glia in brain ischemia
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - December 27, 2017 Category: Neuroscience Authors: Veronica Murta, Priscila Schilrreff, Gerardo Rosciszewski, Maria Jose Morrilla, Alberto Javier Ramos Tags: Original Article Source Type: research
White Matter Degeneration in Vascular and Other Ageing ‐Related Dementias
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - December 6, 2017 Category: Neuroscience Authors: Yoshika Hase, Karen Horsburgh, Masafumi Ihara, Raj N. Kalaria Tags: Review Source Type: research
Hexokinase 2 ‐dependent Hyperglycolysis Driving Microglial Activation Contributes to Ischemic Brain Injury
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - December 5, 2017 Category: Neuroscience Authors: Yuan Li, Bingzheng Lu, Longxiang Sheng, Zhu Zhu, Hongjiaqi Sun, Yuwei Zhou, Yang Yang, Dongdong Xue, Wenli Chen, Xuyan Tian, Yun Du, Min Yan, Wenbo Zhu, Fan Xing, Kai Li, Suizhen Lin, Pengxin Qiu, Xingwen Su, Yijun Huang, Guangmei Yan, Wei Yin Tags: Original Article Source Type: research
Neuroprotection mediated post ‐ischemically by a non‐peptidic δ‐opioid receptor agonist, Tan‐67, in ischemic stroke mice is associated with altered amyloid precursor protein expression, maturation and processing
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - November 29, 2017 Category: Neuroscience Authors: Jia ‐Wei Min, Yanying Liu, David Wang, Fangfang Qiao, Hongmin Wang Tags: Original Article Source Type: research
Intra ‐arterial transplantation of human bone marrow mesenchymal stem cells (hBMMSCs) improves behavioral deficits and alters gene expression in rodent stroke model
In conclusion, hBMMSCs administration significantly improves the behavioral deficits by improving motor and locomotor co‐ordination. The promoter of TSP1 and WNK1 genes was found to be hyper‐methylated in hBMMSCs group resulting in their decreased expression while the promoter of ANP and BDNF was found to be hypo‐methylated. This study might shed a light on how hBMMSCs affect the gene expression by modulating methylation status.
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - October 19, 2017 Category: Neuroscience Authors: Vibhuti, Rehan Khan, Alpana Sharma, Suman Jain, Sujata Mohanty, Kameshwar Prasad Tags: Original Article Source Type: research
Cerebral Amyloid Angiopathy as a Cause of Neurodegeneration
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - August 21, 2017 Category: Neuroscience Authors: Eric E. Smith Tags: Review Source Type: research
Salvianolic Acids Enhance Cerebral Angiogenesis and Neurological Recovery by Activating JAK2/STAT3 Signaling Pathway after Ischemic Stroke in Mice
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - August 3, 2017 Category: Neuroscience Authors: Yaoru Li, Xiangjian Zhang, Lili Cui, Rong Chen, Ye Zhang, Cong Zhang, Xingyuan Zhu, Tingting He, Zuyuan Shen, Lipeng Dong, Jingru Zhao, Ya Wen, Xiufen Zheng, Pan Li Tags: Original Article Source Type: research
Tumor necrosis factor receptor ‐associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress
This study was designed to explore changes of expression level and potential roles and mechanisms of TRAF6 in early brain injury (EBI) after SAH using a Sprague–Dawley rat model of SAH induced in 0.3 mL non‐heparinized autologous arterial blood injected into the pre‐chiasmatic cistern. First, compared with the sham group, we found that the expression levels of TRAF6 increased gradually and peaked at 24 h after SAH. Second, the results showed that application of TRAF6 over‐expression plasmid and genetic silencing siRNA could increase or decrease expression of TRAF6, respectively, and severely exacerbate or relieve...
Source: Journal of Neurochemistry - June 20, 2017 Category: Neuroscience Authors: Yang Dou, Haitao Shen, Dongxia Feng, Haiying Li, Xiaodi Tian, Jian Zhang, Zhong Wang, Gang Chen Tags: Original Article Source Type: research
Unconventional role of voltage ‐gated proton channels (VSOP/Hv1) in regulation of microglial ROS production
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - June 1, 2017 Category: Neuroscience Authors: Takafumi Kawai, Yoshifumi Okochi, Tomohiko Ozaki, Yoshio Imura, Schuichi Koizumi, Maya Yamazaki, Manabu Abe, Kenji Sakimura, Toshihide Yamashita, Yasushi Okamura Tags: Original Article Source Type: research
A new insight into the ability to resist Ischemic brain injury: Does hibernation matter?
Read the commented article ‘Arctic ground squirrel hippocampus tolerates oxygen glucose deprivation independent of hibernation season even when not hibernating and after ATP depletion, acidosis and glutamate efflux’ on doi: 10.1111/jnc.13996.
In humans, the blockage of cerebral arteries causes a decrease in blood flow to the brain, resulting in ischemic injury. Moreover, reduced blood flow restricts delivery of nutrients such as glucose and removal of metabolic waste. In stroke patients, ischemic brain injury is a major medical issue. Much can be learned from a model system such as the Artic ground squirrel (AGS) on h...
Source: Journal of Neurochemistry - May 24, 2017 Category: Neuroscience Authors: Thomas I. Nathaniel, Bianca Stewart, Jessica Williams, Michael Hood, Adebobola Imeh ‐Nathaniel Tags: Editorial Comment Source Type: research
Cortical spreading depression preconditioning mediates neuroprotection against ischemic stroke by inducing AMP ‐activated protein kinase‐dependent autophagy in a rat cerebral ischemic/reperfusion injury model
In this study, we topically applied a pledget soaked in 1 mol/L KCl solution on rat cortex for 2 h to elicite CSD or 1 mol/L NaCl solution as a control. The results demonstrated that CSD preconditioning significantly decreased the infarct volume, neurological deficits and neuronal apoptosis in the cortical penumbra of middle cerebral artery occlusion rats, which was inhibited by the autophagy inhibitor 3‐methyladenine (3‐MA, 200 nmol). Furthermore, CSD increased the protein levels of the autophagy markers LC3‐II, Beclin‐1 and the p‐AMPK (Thr172)/AMPK ratio at 12 h and decreased P62 and p‐P70S6K (Thr389). M...
Source: Journal of Neurochemistry - January 11, 2017 Category: Neuroscience Authors: Pingping Shen, Shuai Hou, Mingqin Zhu, Mingming Zhao, Yibing Ouyang, Jiachun Feng Tags: Original Article Source Type: research
Structural and functional brain alterations in a murine model of Angiotensin II ‐induced hypertension
Abstract
Hypertension is a main risk factor for the development of cerebral small vessel disease (cSVD) – a major contributor to stroke and the most common cause of vascular dementia. Despite the increasing socioeconomic importance arising from cSVD, currently only a few specific treatment strategies with proven efficacy are known. Fundamental to the lack of specific treatments is poor understanding of the disease pathogenesis and a lack of appropriate animal models resembling all symptoms of the human disease. However, chronic hypertensive rat models have been shown to bear similarities to most key features of cSVD. Des...
Source: Journal of Neurochemistry - December 20, 2016 Category: Neuroscience Authors: Anja Meissner, Jens Minnerup, Guadalupe Soria, Anna M Planas Tags: Original Article Source Type: research
