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Source: Journal of Neurochemistry
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Total 123 results found since Jan 2013.
High ‐frequency repetitive magnetic stimulation rescues ischemia‐injured neurons through modulation of glial‐derived neurotrophic factor present in the astrocyte's secretome
This study aims to identify the effects triggered by high-frequency repetitive magnetic stimulation (HF-rMS) on astrocytes that contribute to its neuroprotective effects. Neuron-glia and astrocyte cortical cultures subject to oxygen and glucose deprivation were used as an in vitro model of ischemia. Neuroprotection promoted by HF-rMS was evaluated by analysis of markers of neuronal activity and morphometric analysis of neurons. Glial reactivity was determined by immunocytochemistry. The levels of growth factors in the astrocyte conditioned medium (CM) were assessed through a Growth Factor Array and glial-derived neurotroph...
Source: Journal of Neurochemistry - December 7, 2022 Category: Neuroscience Authors: Genilso Gava ‐Junior,
Susana A. Ferreira,
Cláudio Roque,
Julieta Mendes‐Oliveira,
Inês Serrenho,
Nuno Pinto,
Maria Vaz Patto,
Graça Baltazar Tags: ORIGINAL ARTICLE Source Type: research
Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex, and Parkinson's disease ‐related changes
Transfer RNA fragments (tRFs) are important regulatory small RNAs with diverse functions. We studied age, sex, and Parkinson's disease (PD) effects on the distributions of tRFs in the cerebrospinal fluid (CSF) and blood, in NIH and PPMI datasets. We discovered that CSF tRFs were more variable in length and cleavage subtypes, negatively correlated with age and showed more pronounced differences between males and females than blood tRFs. Both CSF and blood tRFs differentiated PD patients from controls, based on distinct subsets of tRFs, both highly enriched with mitochondrial Cholino-tRFs. Our findings point at tRFs as a pro...
Source: Journal of Neurochemistry - November 23, 2022 Category: Neuroscience Authors: Iddo Paldor,
Nimrod Madrer,
Shani Vaknine Treidel,
Dana Shulman,
David S. Greenberg,
Hermona Soreq Tags: ORIGINAL ARTICLE Source Type: research
Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex and Parkinson's disease ‐related changes
AbstractTransfer RNA fragments (tRFs) have recently been shown to be an important family of small regulatory RNAs with diverse functions. Recent reports have revealed modified tRF blood levels in a number of nervous system conditions including epilepsy, ischemic stroke and neurodegenerative diseases, but little is known about tRF levels in the cerebrospinal fluid (CSF). To address this issue, we studied age, sex and Parkinson's disease (PD) effects on the distributions of tRFs in the CSF and blood data of healthy controls and PD patients from the NIH and the Parkinson's Progression Markers Initiative (PPMI) small RNA-seq d...
Source: Journal of Neurochemistry - November 11, 2022 Category: Neuroscience Authors: Iddo Paldor,
Nimrod Madrer,
Shani Vaknine Treidel,
Dana Shulman,
David S. Greenberg,
Hermona Soreq Tags: ORIGINAL ARTICLE Source Type: research
Inhibition of interaction between ROCK1 and Rubicon restores autophagy in endothelial cells and attenuates brain injury after prolonged ischemia
AbstractAbstractAcute ischemic stroke (AIS) induces cerebral endothelial cells death resulting in the breakdown of blood-brain barrier (BBB). Endothelial cells autophagy acts as a protective mechanism against cell death. Autophagy is activated in the very early stages of ischemic stroke and declines after prolonged ischemia. Previous studies have shown that Rubicon can inhibit autophagy. The current study aimed to investigate whether continuous long-term ischemia can inhibit autophagy in endothelial cells after ischemic stroke by regulating the function of Rubicon and its underlying mechanism.Wild-type male C57BL/6J mice w...
Source: Journal of Neurochemistry - November 6, 2022 Category: Neuroscience Authors: Yinyao Lin,
Zexin Zhan,
Mengyan Hu,
Haiyan Li,
Bingjun Zhang,
Ruizhen Wu,
Sha Tan,
Yilong Shan,
Zhengqi Lu,
Bing Qin Tags: ORIGINAL ARTICLE Source Type: research
LncRNA nuclear ‐enriched abundant transcript 1 aggravates cerebral ischemia/reperfusion injury through activating early growth response‐1/RNA binding motif protein 25 axis
In conclusion, this work identified a novel NEAT1/EGR1/RBM25 axis in potentiating brain injury after IR insults, suggesting a potential therapeutic target for ischemic stroke.
Source: Journal of Neurochemistry - August 23, 2022 Category: Neuroscience Authors: Jing ‐Wei Cao,
Zhan‐Bin Tang,
Ji‐Wei Zhao,
Jing‐Kun Zhao,
Jia‐Lin Yao,
Xiao‐Meng Sheng,
Mian‐Qiao Zhao,
Qiong Duan,
Bai‐Chao Han,
Shu‐Rong Duan Tags: ORIGINAL ARTICLE Source Type: research
Sphingosine ‐1‐phosphate receptor modulators in stroke treatment
AbstractSphingosine-1-phosphate (S1P) is a bioactive lysophospholipid that can influence a broad range of biological processes through its binding to five distinct G protein-coupled receptors. S1P receptor modulators are a new group of immunosuppressive agents currently used in the immunotherapy of multiple sclerosis. Inflammation following stroke may exacerbate injury. Given that S1P signaling is linked to multiple immune processes, therapies targeting the S1P axis may be suitable for treating stroke. In this review, we outline S1P metabolism and S1P receptors, discuss the mechanisms of action of S1P receptor modulators i...
Source: Journal of Neurochemistry - August 9, 2022 Category: Neuroscience Authors: Wanzhou Zhang,
Yudi Li,
Fangming Li,
Li Ling Tags: REVIEW Source Type: research
Circulating metabolites associated with incident myocardial infarction and stroke: a prospective cohort study of 90,438 participants
AbstractThe relevance between circulating metabolites and vascular events remains controversial and comprehensive studies are lacking. We sought to investigate the prospective associations of plasma metabolomics with risks of incident stroke, ischemic stroke (IS), hemorrhagic stroke (HS) and myocardial infarction (MI). Within the UK Biobank cohort, 249 circulating metabolites were measured in 90,438 participants without baseline vascular diseases. Cox proportional hazards regressions were applied to estimate adjusted hazard ratios (HRs) for per 1 standard deviation increment in metabolites. The least absolute shrinkage and...
Source: Journal of Neurochemistry - June 28, 2022 Category: Neuroscience Authors: Yu Guo,
Shu ‐Fen Chen,
Ya‐Ru Zhang,
Hui‐Fu Wang,
Shu‐Yi Huang,
Shi‐Dong Chen,
Yue‐Ting Deng,
Bang‐Sheng Wu,
Kevin Kuo,
Rong‐Ze Wang,
Qiang Dong,
Jian‐Feng Feng,
Wei Cheng,
Jin‐Tai Yu Tags: ORIGINAL ARTICLE Source Type: research
Ying Yang 1 engagement in brain pathology
AbstractHerein, we discuss data concerning the involvement of transcription factor Yin Yang 1 (YY1) in the development of brain diseases, highlighting mechanisms of its pathological actions. YY1 plays an important role in the developmental and adult pathology of the nervous system. YY1 is essential for neurulation as well as maintenance and differentiation of neuronal progenitor cells and oligodendrocytes regulating both neural and glial tissues of the brain. Lack of a YY1 gene causes many developmental abnormalities and anatomical malformations of the central nervous system (CNS). Once dysregulated, YY1 exerts multiple ne...
Source: Journal of Neurochemistry - February 24, 2022 Category: Neuroscience Authors: Sylwia Pabian ‐Jewuła,
Aneta Bragiel‐Pieczonka,
Marcin Rylski Tags: SYSTEMATIC REVIEW Source Type: research
Issue Information
Front cover:Restoring the cerebral blood flow and minimizing the loss of neurons are the two main aims in acute stroke therapy, in order to preserve energy supply to the neurons and other cells in the brain. The brain ’s energy homeostasis is therefore an important target in stroke therapy. The various articles in this special issue “Stroke and Energy Metabolism” pinpoint the hotspots of energy metabolism changes following stroke, including disturbed cerebral blood circulation, mitochondrial dysfunction, pr ogrammed neuronal cell death, and cell-cell communications for brain metabolism, to provide insights and toe-ho...
Source: Journal of Neurochemistry - December 29, 2021 Category: Neuroscience Tags: Issue Information Source Type: research
Disturbed cerebral circulation and metabolism matters
Stroke is a serious neurological disorder caused by blockage or rupture of cerebral blood vessels. Maintenance of energy homeostasis in the brain drives neural network dynamics, which preserves normal brain function under physiological conditions. As such, cerebral energy homeostasis is a key target in stroke therapy. The various articles in this special issue “Stroke and Energy Metabolism” highlight energy metabolism changes following stroke, including disturbed cerebral blood circulation, mitochondrial dysfunction, programmed neuronal cell death and cell–cell communication in brain metabolism. Collectively, this se...
Source: Journal of Neurochemistry - December 11, 2021 Category: Neuroscience Authors: Yujie Chen Tags: EDITORIAL Source Type: research
Antimicrobial Protein REG3A and Signaling Networks are Predictive of Stroke Outcomes
AbstractRegenerating Family Member 3 Alpha (REG3A) is a multifunctional protein with antimicrobial activity, and primarily secreted by the intestine and pancreas. Studies have shown an increased expression of REG3A in systemic inflammatory responses to acute injury and infection, but studies investigating REG3A during the pathogenesis of ischemic stroke are limited. The aims of this study were to examine the associations between arterial expression of REG3A and other arterial inflammatory proteins implicated in stroke pathogenesis, as well as associations between REG3A and markers of poor outcome for ischemic stroke. The U...
Source: Journal of Neurochemistry - September 24, 2021 Category: Neuroscience Authors: Madison Sands,
Jacqueline A. Frank,
Benton Maglinger,
Christopher J. McLouth,
Amanda L. Trout,
Jadwiga Turchan ‐Cholewo,
Ann M. Stowe,
Justin F. Fraser,
Keith R. Pennypacker Tags: ORIGINAL ARTICLE Source Type: research
Targeting focal ischemic and hemorrhagic stroke neuroprotection: current prospects for local hypothermia
AbstractTherapeutic hypothermia (TH) has applications dating back millennia. In modern history, however, TH saw its importation into medical practice where investigations have demonstrated that TH is efficacious in ischemic insults, notably cardiac arrest and hypoxic-ischemic encephalopathy. As well, studies have been undertaken to investigate whether TH can provide benefit in focal stroke (i.e., focal ischemia and intracerebral hemorrhage). However, clinical studies have encountered various challenges with induction and maintenance of post-stroke TH. Most clinical studies have attempted to use body-wide cooling protocols,...
Source: Journal of Neurochemistry - September 9, 2021 Category: Neuroscience Authors: Lane J. Liddle,
Anna C.J. Kalisvaart,
Ashley H. Abrahart,
Mohammed Almekhlafi,
Andrew Demchuk,
Frederick Colbourne Tags: REVIEW Source Type: research
Neurosteroids: a novel promise for the treatment of stroke and post ‐stroke complications
AbstractStroke is the primary reason for death and disability worldwide, with few treatment strategies to date. Neurosteroids, which are natural molecules in the brain, have aroused great interest in the field of stroke. Neurosteroids are a kind of steroid that acts on the nervous system, and are synthesized in the mitochondria of neurons or glial cells using cholesterol or other steroidal precursors. Neurosteroids mainly include estrogen, progesterone (PROG), allopregnanolone, dehydroepiandrosterone (DHEA), and vitamin D (VD). Most of the preclinical studies have confirmed that neurosteroids can decrease the risk of strok...
Source: Journal of Neurochemistry - September 5, 2021 Category: Neuroscience Authors: Jiawei Xu,
Yunxiang Zhou,
Caochong Yan,
Xiaoyu Wang,
Jianyao Lou,
Yi Luo,
Shiqi Gao,
Junjie Wang,
Liang Wu,
Xiangfu Gao,
Anwen Shao Tags: REVIEW ARTICLE Source Type: research
Spontaneous, transient adenosine release is not enhanced in the CA1 region of hippocampus during severe ischemia models
AbstractIschemic stroke causes damage in the brain and a slow buildup of adenosine is neuroprotective during ischemic injury. Spontaneous, transient adenosine signaling, lasting only 3 seconds per event, has been discovered that increases in frequency in the caudate-putamen during early stages of mild ischemia-reperfusion injury. However, spontaneous adenosine changes have not been studied in the hippocampus during ischemia, an area highly susceptible to stroke. Here, we investigated changes of spontaneous, transient adenosine in the CA1 region of rat hippocampus during three different models of varied intensity of ischemi...
Source: Journal of Neurochemistry - August 29, 2021 Category: Neuroscience Authors: Mallikarjunarao Ganesana,
B. Jill Venton Tags: ORIGINAL ARTICLE Source Type: research
Metabolic determinants of leukocyte pathogenicity in neurological diseases
Immune cells finely tune their intracellular metabolic activity upon activation, and such metabolic changes are crucial for their polarization, effector functions and pathogenicity. In this manuscript, we review our current knowledge about the metabolic profiles of circulating immune cells in neurodegenerative and neuroinflammatory disease, with a focus on Alzheimer's and Parkinson's diseases, stroke, and multiple sclerosis. We also discuss the importance of these metabolic changes on the development of such life-threatening diseases, and highlight how impacting immune cell metabolism may represent a novel and innovative a...
Source: Journal of Neurochemistry - July 14, 2021 Category: Neuroscience Authors: Marah C. Runtsch,
Giovanni Ferrara,
Stefano Angiari Tags: REVIEW Source Type: research
