Filtered By:
Specialty: Geriatrics
Source: AGE
This page shows you your search results in order of date. This is page number 2.
Order by Relevance | Date
Total 43 results found since Jan 2013.
Hippocampus is more susceptible to hypoxic injury: has the Rosetta Stone of regional variation in neurovascular coupling been deciphered?
AbstractAlzheimer ’s disease and Alzheimer’s disease–related dementias (AD/ADRD) are associated with cerebral hypoperfusion or reductions in baseline cerebral blood flow (CBF). The neurovascular coupling (NVC) response or functional hyperemia regulates brain perfusion via a retrograde (capillary-to-arteriole) p athway by increasing regional CBF in response to local neuron activation. The hippocampus plays a significant role in spatial and non-spatial memory. Functional MRI (fMRI) has not established a solid positive correlation between hippocampal blood oxygen level–dependent (BOLD) signal and local neur onal activ...
Source: AGE - February 1, 2022 Category: Geriatrics Source Type: research
Mesenchymal stromal cell-derived small extracellular vesicles promote neurological recovery and brain remodeling after distal middle cerebral artery occlusion in aged rats
This study encourages further proof-of-concept studies in clinic-relevant stroke settings.
Source: AGE - February 1, 2022 Category: Geriatrics Source Type: research
Leukocyte-derived ratios are associated with late-life any type dementia: a cross-sectional analysis of the Mugello study
AbstractImmunosenescence, vascular aging, and brain aging, all characterized by elevated levels of inflammatory markers, are thought to share a common pathogenetic pathway: inflamm-aging. Retrospective cross-sectional analysis was conducted using data from the Mugello study (Tuscany, Italy), a representative Italian cohort of free-living nonagenarians. to assess the association between specific peripheral inflammation markers derived from white blood cell counts, and the diagnosis of dementia. All the variables of interest were reported for 411 subjects (110 males and 301 females) out of 475 enrolled in the study. Anamnest...
Source: AGE - December 1, 2021 Category: Geriatrics Source Type: research
Cardiovascular risk prediction in healthy older people
AbstractIdentification of individuals with increased risk of major adverse cardiovascular events (MACE) is important. However, algorithms specific to the elderly are lacking. Data were analysed from a randomised trial involving 18,548 participants ≥ 70 years old (mean age 75.4 years), without prior cardiovascular disease events, dementia or physical disability. MACE included coronary heart disease death, fatal or nonfatal ischaemic stroke or myocardial infarction. Potential predictors tested were based on prior evidence and using a m achine-learning approach. Cox regression analyses were used to calculate 5-year p...
Source: AGE - November 11, 2021 Category: Geriatrics Source Type: research
Mesenchymal stromal cell-derived small extracellular vesicles promote neurological recovery and brain remodeling after distal middle cerebral artery occlusion in aged rats
This study encourages further proof-of-concept studies in clinic-relevant stroke settings.
Source: AGE - November 10, 2021 Category: Geriatrics Source Type: research
Leukocyte-derived ratios are associated with late-life any type dementia: a cross-sectional analysis of the Mugello study
AbstractImmunosenescence, vascular aging, and brain aging, all characterized by elevated levels of inflammatory markers, are thought to share a common pathogenetic pathway: inflamm-aging. Retrospective cross-sectional analysis was conducted using data from the Mugello study (Tuscany, Italy), a representative Italian cohort of free-living nonagenarians. to assess the association between specific peripheral inflammation markers derived from white blood cell counts, and the diagnosis of dementia. All the variables of interest were reported for 411 subjects (110 males and 301 females) out of 475 enrolled in the study. Anamnest...
Source: AGE - October 21, 2021 Category: Geriatrics Source Type: research
Hippocampus is more susceptible to hypoxic injury: has the Rosetta Stone of regional variation in neurovascular coupling been deciphered?
AbstractAlzheimer ’s disease and Alzheimer’s disease–related dementias (AD/ADRD) are associated with cerebral hypoperfusion or reductions in baseline cerebral blood flow (CBF). The neurovascular coupling (NVC) response or functional hyperemia regulates brain perfusion via a retrograde (capillary-to-arteriole) p athway by increasing regional CBF in response to local neuron activation. The hippocampus plays a significant role in spatial and non-spatial memory. Functional MRI (fMRI) has not established a solid positive correlation between hippocampal blood oxygen level–dependent (BOLD) signal and local neur onal activ...
Source: AGE - August 28, 2021 Category: Geriatrics Source Type: research
Impact of COVID-19 on ischemic stroke care in Hungary
AbstractData about the coronavirus disease 2019 (COVID-19) pandemic ’s collateral damage on ischemic stroke (IS) care during the second epidemic wave in Central Europe are limited. We sought to evaluate the impact of the COVID-19 outbreak on Hungarian IS care during the two epidemic waves. This retrospective observational study was based on a nationwide reimbursem ent database that encompasses all IS admissions and all reperfusion interventions, i.e., intravenous thrombolysis (IVT) and endovascular therapy (EVT) from 2 January 2017 to 31 December 2020 in Hungary. COVID-19 pandemic’s effect on the number of IS admission...
Source: AGE - August 18, 2021 Category: Geriatrics Source Type: research
Effect of environmental enrichment and isolation on behavioral and histological indices following focal ischemia in old rats
AbstractStroke is a disease of aging. In stroke patients, the enriched group that received stimulating physical, eating, socializing, and group activities resulted in higher activity levels including spending more time on upper limb, communal socializing, listening and iPad activities. While environmental enrichment has been shown to improve the behavioral outcome of stroke in young animals, the effect of an enriched environment on behavioral recuperation and histological markers of cellular proliferation, neuroinflammation, and neurogenesis inold subjects is not known. We used behavioral testing and immunohistochemistry t...
Source: AGE - August 12, 2021 Category: Geriatrics Source Type: research
Blood –brain barrier leakage at baseline and cognitive decline in cerebral small vessel disease: a 2-year follow-up study
In this study, we investigated the link between BBB leakage and cognitive dec line over 2 years in patients with cSVD. At baseline, 51 patients with clinically overt cSVD (lacunar stroke or mild vascular cognitive impairment) received a dynamic contrast-enhanced MRI scan to quantify BBB permeability in the normal-appearing white matter (NAWM), white matter hyperintensities ( WMH), cortical grey matter (CGM), and deep grey matter (DGM). Cognitive function in the domain executive function, information processing speed, and memory was measured in all patients at baseline and after 2 years. The association between baseline B...
Source: AGE - June 23, 2021 Category: Geriatrics Source Type: research
Increased procoagulant platelet levels are predictive of death in COVID-19
AbstractPrior research has identified abnormal platelet procoagulant responses in COVID-19. Coated-platelets, a form of procoagulant platelets, support thrombin formation and are elevated in ischemic stroke patients with increased risk for recurrent infarction. Our goal was to examine changes in coated-platelet levels over the course of COVID-19 infection and determine their association with disease severity, thrombosis, and death. Coated-platelet levels were assayed after admission and repeated weekly in COVID-19 patients, and in COVID-19 negative controls. Receiver operator characteristic (ROC) analysis was used to calcu...
Source: AGE - June 9, 2021 Category: Geriatrics Source Type: research
The association of proBNPage with manifestations of age-related cardiovascular, physical, and psychological impairment in community-dwelling older adults
AbstractNT-proB-type natriuretic peptide (NT-proBNP) serum concentration can be transformed by simple formulas into proBNPage, a surrogate of biological age strongly associated with chronological age, all-cause mortality, and disease count. This cross-sectional study aimed to assess whether proBNPage is also associated with other manifestations of the aging process in comparison with other variables. The study included 1117 noninstitutionalized older adults (73.1 ± 5.6 years, 537 men). Baseline measurements of serum NT-proBNP, erythrocyte sedimentation rate, hemoglobin, lymphocytes, and creatinine, which have previo...
Source: AGE - May 13, 2021 Category: Geriatrics Source Type: research
Left-ventricular hypertrophy in 18-month-old donor rat hearts was not associated with graft dysfunction in the early phase of reperfusion after cardiac transplantation –gene expression profiling
AbstractThe use of hearts with left-ventricular (LV) hypertrophy (LVH) could offer an opportunity to extend the donor pool for cardiac transplantation. We assessed the effects of LVH in 18-month-old spontaneously hypertensive stroke-prone (SHRSP) donor rats and following transplantation. In donors, cardiac function and structural alterations were assessed. Then, the hearts were transplanted into young normotensive-rats. We evaluated LV graft function 1 h after transplantation. The myocardial expression of 92 genes involved in apoptosis, inflammation, and oxidative-stress was profiled using PCR-array. Compared to controls, ...
Source: AGE - April 19, 2021 Category: Geriatrics Source Type: research
Cerebral hemodynamics in obesity: relationship with sex, age, and adipokines in a cohort-based study
AbstractOverweight and obesity are well-known independent risk factors for stroke in the general population although uncertain in the case of the elderly, according to the obesity paradox. Little is known about underlying mechanisms. Our study aims to assess whether there is a relationship between excess body weight (measured as waist circumference) and poor cerebral hemodynamics (measured by transcranial Doppler parameters: basal, mean flow velocity (MFV), and dynamic, cerebrovascular reserve (CvR) in the right middle cerebral artery (RMCA)). A possible underlying molecular mechanism was analyzed via plasma leptin, adipon...
Source: AGE - January 15, 2021 Category: Geriatrics Source Type: research
Role of B cells and the aging brain in stroke recovery and treatment
AbstractAs mitigation of brain aging continues to be a key public health priority, a wholistic and comprehensive consideration of the aging body has identified immunosenescence as a potential contributor to age-related brain injury and disease. Importantly, the nervous and immune systems engage in bidirectional communication and can exert profound influence on each other. Emerging evidence supports numerous impacts of innate, inflammatory immune responses and adaptive T cell –mediated immunity in neurological function and diseased or injured brain states, such as stroke. Indeed, a growing body of evidence supports key im...
Source: AGE - August 6, 2020 Category: Geriatrics Source Type: research
