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Clinical significance of skin autofluorescence for diabetic macroangiopathy and comparison with conventional markers of atherosclerosis: a cross-sectional and prospective study
ConclusionAmong diabetic macroangiopathies, SAF is a good stroke biomarker, but not for CAD and PAD.
Source: Diabetology International - November 28, 2022 Category: Endocrinology Source Type: research

Effect of linagliptin, a dipeptidyl peptidase-4 inhibitor, compared with the sulfonylurea glimepiride on cardiovascular outcomes in Asians with type 2 diabetes: subgroup analysis of the randomized CAROLINA ® trial
ConclusionsIn Asian patients, linagliptin demonstrated similar CV safety to glimepiride with a markedly lower rate of hypoglycemia and modestly lower weight.
Source: Diabetology International - June 26, 2020 Category: Endocrinology Source Type: research

Linagliptin and cardiorenal outcomes in Asians with type 2 diabetes mellitus and established cardiovascular and/or kidney disease: subgroup analysis of the randomized CARMELINA ® trial
ConclusionsLinagliptin showed cardiovascular and renal safety in Asian patients with T2DM and established CVD with albuminuria and/or kidney disease.
Source: Diabetology International - October 21, 2019 Category: Endocrinology Source Type: research

The effect of long-term past glycemic control on executive function among patients with type 2 diabetes mellitus
ConclusionsFive-year HbA1c variability affected executive function in T2DM patients, but not average HbA1c values. Long-term longitudinal studies may be required.
Source: Diabetology International - October 2, 2019 Category: Endocrinology Source Type: research

Clinical background of Japanese patients with type 1 diabetes mellitus who have received insulin therapy for 50  years or longer
ConclusionsIt became possible for patients with T1DM to live more than 50  years in Japan.
Source: Diabetology International - April 10, 2019 Category: Endocrinology Source Type: research

Clinical characteristics of Japanese diabetic patients with critical limb ischemia presenting Fontaine stage IV
In conclusion, the advanced stage of diabetes-related complications was prevalent in patients with CLI presenting Fontaine stage IV.
Source: Diabetology International - December 8, 2018 Category: Endocrinology Source Type: research

Salt and hypertension in diabetes
AbstractWorldwide, the number of patients with diabetes is increasing. Adults with diabetes have a two- to threefold increased risk of heart attack and stroke, and diabetic nephropathy is a leading cause of end-stage renal failure. Salt sensitivity of blood pressure is reported to be elevated in patients with diabetes. Hyperinsulinemia, hyperglycemia, and an activated sympathetic nervous system play key roles in the genesis of salt-sensitive blood pressure in individuals who are obese and/or have type 2 diabetes. In this review, I summarize previous research performed to improve our understanding of the relationship betwee...
Source: Diabetology International - January 27, 2017 Category: Endocrinology Source Type: research

Risk factors associated with abnormal cognition in Japanese outpatients with diabetes, hypertension or dyslipidemia
Conclusions Because of the higher prevalence of abnormal cognition in aged outpatients with diabetes found in primary care practice and significant associations with serum albumin, uric acid, renal function, retinopathy and antidiabetic drugs, there is a need for early diagnosis and strategies against dementia.
Source: Diabetology International - November 9, 2014 Category: Endocrinology Source Type: research