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The eicosapentaenoic acid:arachidonic acid ratio and its clinical utility in cardiovascular disease.
Authors: Nelson JR, Raskin S Abstract Eicosapentaenoic acid (EPA) is a key anti-inflammatory/anti-aggregatory long-chain polyunsaturated omega-3 fatty acid. Conversely, the omega-6 fatty acid, arachidonic acid (AA) is a precursor to a number of pro-inflammatory/pro-aggregatory mediators. EPA acts competitively with AA for the key cyclooxygenase and lipoxygenase enzymes to form less inflammatory products. As a result, the EPA:AA ratio may be a marker of chronic inflammation, with a lower ratio corresponding to higher levels of inflammation. It is now well established that inflammation plays an important role in card...
Source: Postgraduate Medicine - May 9, 2019 Category: Internal Medicine Tags: Postgrad Med Source Type: research