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Source: The Journal of Heart and Lung Transplantation
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Total 231 results found since Jan 2013.
Paradoxical Mechano-Energetic Costs of Acute Mechanical Intra-Ventricular Unloading: A Key to Understand Myocardial Recovery with Left-Ventricular Mechanical Support?
This study tested such hypothesis by assessing the acute effects of LVAD support on systemic hemodynamics, left-ventricular (LV) mechano-energetics and myocardial oxygen consumption (MVO2) in vivo.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: S. Bennett, C.L. del Rio, J. Noel-Morgan, E. Geist, Y. Ueyama, E. Ferris, B. Youngblood, P.I. McConnell Source Type: research
RVOT-VTI/PASP Is a Novel Noninvasive Parameter of Pulmonary Artery Compliance and Improves After Treatment with Pulmonary Hypertension-Specific Therapy
Pulmonary artery compliance (PAC) is an independent predictor of mortality in patients with pulmonary hypertension (PH). We have previously shown that the ratio of echocardiography derived right ventricular outflow tract velocity time integral (RVOT-VTI; an estimate of stroke volume) to pulmonary artery systolic pressure (PASP) correlates with PAC measured by right heart catheterization. We sought to determine whether PH-specific therapy improves PAC in patients with pulmonary arterial hypertension (PAH).
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: M.S. Tanna, A. Fox, G.S. Troutman, P.T. Bhattacharya, J.N. Menachem, F. Mao, E.Y. Birati, P.R. Forfia, A. Vaidya, J.A. Mazurek Source Type: research
Use of TEG/Platelet Mapping to Dose-Adjust Platelet Inhibitors in Children Supported with the Berlin EXCOR: In Search of a Correlation
There is uncertain correlation between doses of aspirin (ASA), dipyridamole (DPM) and clopidogrel (CLP) and the absolute % inhibition as measured by Platelet Mapping, a platelet function test that accompanies Thromboelastography (TEG). This is particularly relevant for children supported with the Berlin EXCOR pediatric ventricular assist device (VAD), as the TEG/PM is currently used to adjust their antiplatelet medications but the stroke rate remains unacceptably high. We sought to determine whether there was better correlation between medication doses and the relative change from baseline in the % inhibition.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: L.J. May, X. Liu, C. Sherwin, L. Yang, J. Zhender, J. Lee, S. Chen, D.N. Rosenthal, C.S. Almond Source Type: research
Increased Frequency of Bleeding Complications in Females Following LVAD Implant
While females are at increased risk for stroke after left ventricular assist device (LVAD), the impact of sex on mortality has been met with conflicting results and there is few data on sex specific bleeding rates. Bleeding is a major source of morbidity and mortality in the LVAD population. The aim of this analysis is to define the incidence and clinical impact of bleeding stratified by sex.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: Z. Yavar, J. Cowger, S. Moainie, C. Salerno, A.K. Ravichandran Source Type: research
Outcomes of Asian-Americans Undergoing Left Ventricular Assist Device Implantations as a Bridge to Transplant or Destination Therapy: An INTERMACS Analysis
Previous studies have demonstrated significant differences between Asians and Caucasian white populations in their propensity for stroke, coronary artery disease, heart failure, inflammation, bleeding and thrombosis. Therefore, we hypothesized that Asian Americans with end stage heart failure undergoing treatment with durable left ventricular assist devices (LVAD) exhibit a different morbidity and mortality risk profile when compared to non-Asian and white Americans populations.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: J.R. Wever Pinzon, W. Wang, N. Hu, R. Larsen, T. Yu, L. Yin, I. Taleb, A. Koliopoulou, S. Mckellar, J. Stehlik, J. Fang, A. Kfoury, C. Selzman, S. Drakos Source Type: research
Low Dose tPA as a Therapeutic Strategy in Suspected Pump Thrombosis in HeartMate II
Tissue plasminogen activator (tPA) is a known treatment for DVT and thromboembolic stroke. Our study aim was to determine the safety and efficacy of a low dose tPA protocol in suspected pump thrombosis in HMII.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: A.S. Cruz-Solbes, M.I. Achi, J. Amione-Guerra, E. Karanja, B. Trachtenberg, A. Bhimaraj, J. Estep, G. Torre-Amione, I. Hussain, M. Park, B. Bruckner, A. Guha Source Type: research
Management of RVAD Thrombosis in Biventricular HVAD Supported Patients
Pump thrombosis confers significant morbidity and mortality in left ventricular assist device (LVAD) supported patients. Particularly in HVAD, therapeutic approaches including thrombolysis, or adjusting anticoagulation have been recommended as initial treatment but are associated with hemorrhagic stroke and death. Conversely, device exchange has been recommended as a preferred choice with low morbidity-mortality. Biventricular support (BIVAD) utilizing 2 HVAD systems has been proven as a novel way to manage critically ill individuals with biventricular failure.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: J. Silva Enciso, M. Brambatti, H. Tran, G.V. Pretorius, E. Adler Source Type: research
Sildenafil Reduces Risk of Ischemic Stroke and Pump Thrombosis with Ongoing Low Level Hemolysis During Heart Mate II Support
Low level hemolysis after Heart Mate (HM) II implantation, as evident by an elevated discharge lactate dehydrogenase (LDH) level>400 U/L, is linked to subsequent thrombotic events. Free hemoglobin from ongoing hemolysis scavenges nitric oxide (NO) to create a NO deficiency which can augment platelet function. We hypothesized the potentiation of NO signaling during low level hemolysis with a phosphodiesterase-5 inhibitor, sildenafil, may lead to reduced thrombotic events.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: O. Saeed, S. Rangasamy, A. Luke, S.P. Patel, D.B. Sims, J. Shin, M. Reyes Gil, M.J. Slepian, H.H. Billett, D.J. Goldstein, U.P. Jorde Source Type: research
Impact of Body Mass Index on Outcomes After Left Ventricular Assist Device Placement: Evidence from a Meta-Analysis
To investigate the impact of body mass index (BMI) on mortality, rates of device-related infections and stroke/ transient ischemic attack (TIA) after left ventricular assist device (LVAD) placement.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: A. Vallakati, S. Emani, W.T. Abraham Source Type: research
Managing Anticoagulation in LVAD Patients: The Harefield Experience
Anticoagulation management in patients with Left Ventricular Assist devices (LVAD) continues to be a challenge. Patients and their clinicians are faced with the daily challenge of needing adequate anticoagulation versus the bleeding risks that are associated with anticoagulation.Warfarin is the recommended oral anticoagulant for all currently available LVAD devices.Warfarin is known to be a difficult medication to manage due to its narrow therapeutic window, and its many interactions .Dlott et al (2014) describe in Circulation the overall time in therapeutic range for patients on warfarin as 53.7%, Time in therapeutic rang...
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: R. Hards, G. Edwards, C. Kavanagh, M. Hedger, A.R. Simon Source Type: research
The Treatment of Patients with Advanced Heart Failure Ineligible for Cardiac Transplantation with the HeartWare Ventricular Assist Device: Results of the ENDURANCE Supplement Trial
The ENDURANCE Trial previously demonstrated non-inferiority of the HeartWare centrifugal flow ventricular assist device system (HVAD) to the control HeartMate II (HMII) axial flow device in 445 end-stage heart failure patients ineligible for heart transplantation. However, the rate of strokes in the HVAD cohort was higher than expected. Analysis of early clinical trial data found that elevated mean arterial blood pressure (MAP) was a highly statistically significant independent risk factor for stroke events.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: C.A. Milano, J.G. Rogers, A.J. Tatooles, G. Bhat, M.S. Slaughter, E.J. Birks, N.A. Mokadam, C. Mahr, J.S. Miller, V. Jeevanandam, K. Leadley, K.D. Aaronson, F.D. Pagani Source Type: research
The Impact of Age, Sex, Therapeutic Intent, Race, and Severity of Advanced Heart Failure on Short-term Principal Outcomes in the MOMENTUM 3 Trial
Primary outcomes analysis of the MOMENTUM 3 trial short term cohort demonstrated a higher survival rate free of debilitating stroke and reoperation to replace/remove the device (primary endpoint) in patients receiving the HeartMate 3 (HM3) compared to the HeartMate (HMII). We sought to evaluate the individual and interactive effects of pre-specified patient subgroups (age, sex, race, therapeutic intent (BTT/BTC/DT) and severity of illness) on primary endpoint outcomes in MOMENTUM 3 patients implanted with HM3 and HMII.
Source: The Journal of Heart and Lung Transplantation - November 3, 2017 Category: Transplant Surgery Authors: Daniel J. Goldstein, Mandeep R. Mehra, Yoshifumi Naka, Christopher Salerno, Nir Uriel, David Dean, Akinobu Itoh, Francis D. Pagani, Eric R. Skipper, Geetha Bhat, Nirav Raval, Brian A. Bruckner, Jerry D. Estep, Rebecca Cogswell, Carmelo Milano, Lahn Fendel Source Type: research
Ischemic Stroke and Subsequent Thrombosis within a HeartMate 3 Left Ventricular Assist System: A Cautionary Tale
Introduction of the centrifugal continuous flow-pump, the Heartmate 3 Left Ventricular Assist System (LVAS) has been heralded with the unique observation that de-novo pump thrombosis has not been reported to occur with this device in the pivotal clinical trials.1,2 While engineering principles inherent in this LVAS obviate the initial development of thrombosis within the pump, they cannot protect against ingestion of thrombus or other circulating materials. Similarly, if such ingested material (or thrombus) remains trapped within the device and materially influences its function, it may set-up a nidus for propagation of th...
Source: The Journal of Heart and Lung Transplantation - November 6, 2017 Category: Transplant Surgery Authors: Ivan Netuka, Mandeep R. Mehra Source Type: research
Impact of age, sex, therapeutic intent, race and severity of advanced heart failure on short-term principal outcomes in the MOMENTUM 3 trial
In this study we sought to evaluate the individual and interactive effects of pre-specified patient subgroups (age, sex, race, therapeutic intent [bridge to transplant/bridge to candidacy/destination therapy] and severity of illness) on primary end-point outcomes in MOMENTUM 3 patients implanted with HM3 and HMII devices.
Source: The Journal of Heart and Lung Transplantation - November 3, 2017 Category: Transplant Surgery Authors: Daniel J. Goldstein, Mandeep R. Mehra, Yoshifumi Naka, Christopher Salerno, Nir Uriel, David Dean, Akinobu Itoh, Francis D. Pagani, Eric R. Skipper, Geetha Bhat, Nirav Raval, Brian A. Bruckner, Jerry D. Estep, Rebecca Cogswell, Carmelo Milano, Lahn Fendel Tags: Original Clinical Science Source Type: research
Early stroke post-heart transplant is associated with decreased survival in children
Over the past several decades significant advances in the management have improved the postoperative mortality with pediatric heart transplant (HTx) recipients now surviving for years after transplant surgery.1 –3 For most children with end-stage heart failure, transplantation is the only effective long term therapy, placing demands on the limited donor pool resulting in long waitlist time, particularly in infants.4 While waiting, mechanical circulatory support as a bridge to transplant often becomes a l ifesaving measure in these terminal heart failure patients.
Source: The Journal of Heart and Lung Transplantation - January 8, 2018 Category: Transplant Surgery Authors: Cheryl Cammock, Swati Choudhry, Chesney M. Castleberry, Noor Al-Hammadi, Pirooz Eghtesady, Charles E. Canter, Kathleen E. Simpson Source Type: research
