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Source: Journal of Vascular Surgery
Therapy: Statin Therapy
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Total 23 results found since Jan 2013.
Females are Less Likely to Receive Best Medical Therapy for Stroke Prevention Before and After Carotid Revascularization than Males
Current professional guidelines recommend best medical therapy (BMT) with statin agents and antiplatelet therapy for primary and secondary stroke prevention in patients with carotid artery stenosis. We aimed to assess the association of patient sex with preoperative BMT in patients undergoing carotid revascularization.
Source: Journal of Vascular Surgery - October 11, 2022 Category: Surgery Authors: Sanuja Bose, David P. Stonko, Georgina M. Pappas, Laura M. Drudi, Michael C. Stoner, Caitlin W. Hicks Source Type: research
Statins Decrease Risk of Amputation in Patients Undergoing Lower Extremity Open Revascularization Procedures
The objective of this study was to determine the effect of statins on amputation risk and major adverse cardiac events (defined as the composite of myocardial infarction, stroke, and death) in patients with PAD undergoing open lower extremity revascularization.
Source: Journal of Vascular Surgery - May 19, 2022 Category: Surgery Authors: Sungshin Amy Na, Natale Mazzaferro, William E. Beckerman Tags: PC: Poster Competition Source Type: research
The imperative need to identify stroke risk stratification models for patients with asymptomatic carotid artery stenosis
The optimal management of patients with asymptomatic carotid stenosis (ACS) is controversial. The study by Klarin et al1 provides important novel information that challenges the theory claiming that medical treatment (MT) alone is adequate for the management of all patients with ACS and that prophylactic carotid endarterectomy is not justified in any of these patients.2 Klarin et al1 showed that 112 of 219 pat ients (50%) with radiographically confirmed first-ever carotid-related strokes did actually receive antiplatelet therapy before their stroke, and 121 of 219 patients (55%) received lipid-lowering therapy (most ...
Source: Journal of Vascular Surgery - September 20, 2018 Category: Surgery Authors: Kosmas I. Paraskevas, Jean-Baptiste Ricco Tags: Letter to the Editor Source Type: research
Invited commentary
Although carotid endarterectomy and stenting for symptomatic significant carotid artery stenosis are widely accepted for stroke prevention, their use for asymptomatic stenosis is more controversial. With the advances in medical therapy, particularly the use of statins, and with an annual stroke risk of 1% to 2% for asymptomatic disease, justifying these interventions in these patients is more difficult. What is more disturbing is that ∼90% of all carotid endarterectomy and stenting procedures in the United States are performed on asymptomatic patients and that many were felt to be unnecessary, resulting in a cost of>$2 billion annually.
Source: Journal of Vascular Surgery - April 26, 2018 Category: Surgery Authors: Ali F. AbuRahma Tags: From bench to bedside Source Type: research
The effect of statin use and intensity on stroke and myocardial infarction after carotid endarterectomy
Statin use in patients with cerebrovascular disease undergoing carotid endarterectomy (CEA) has been advocated for prevention of stroke and cardiovascular events. However, the effect of statin therapy on long-term outcomes after CEA still needs to be delineated.
Source: Journal of Vascular Surgery - April 20, 2018 Category: Surgery Authors: Nkiruka Arinze, Alik Farber, Teviah Sachs, Gregory Patts, Jeffrey Kalish, Angela Kuhnen, George Kasotakis, Jeffrey J. Siracuse Tags: Clinical paper Source Type: research
The Effect of Statin Use and Intensity After Carotid Endarterectomy
Statin use in patients undergoing carotid endarterectomy (CEA) has been advocated for prevention of postoperative and future stroke and myocardial infarction (MI). However, the effect of duration and intensity of statin therapy on outcomes after CEA has not been investigated.
Source: Journal of Vascular Surgery - July 20, 2017 Category: Surgery Authors: Nkiruka Arinze, Teviah Sachs, Gregory Patts, Jeffrey Kalish, Angela Kuhnen, George Kasotakis, Alik Farber, Jeffrey Siracuse Tags: Abstract from the 2017 New England Society for Vascular Surgery Annual Meeting Source Type: research
FT19. Combination of Preoperative CT and Carotid Plaque Gene Expression Profiling Demonstrates an Association Between Calcification and Plaque-Stabilizing Processes
Unstable carotid stenosis is a major cause of stroke, but we lack methods to identify patients and lesions at risk. We recently described enrichment of molecular pathways associated with vascular calcification in carotid plaques from asymptomatic patients and from patients on statins. Here, we tested the hypothesis that calcification is a stabilizing feature in carotid atherosclerosis and examined whether calcification estimated by computed tomography (CT) can reflect plaque phenotype.
Source: Journal of Vascular Surgery - May 17, 2017 Category: Surgery Authors: Eva Karlof, Nuno Dias, Mariette Lengquist, Anna Witasp, Peter Stenvinkel, Lars Maegdefessel, Ljubica Perisic Matic, Ulf Hedin Tags: FT: International Fast Talk Source Type: research
IP115. Statin Use and Intensity After Carotid Endarterectomy Does Not Affect Short-Term Stroke and Myocardial Infarction Rates
Statin use in patients with cerebrovascular disease undergoing carotid endarterectomy (CEA) has been advocated. However, the intensity of statin therapy and its effect on short and long-term outcomes after CEA are unclear.
Source: Journal of Vascular Surgery - May 17, 2017 Category: Surgery Authors: Nkiruka Arinze, Teviah Sachs, Alik Farber, Angela H. Kuhnen, George Kasotakis, Gregory Patts, Jeffrey Kalish, Jeffrey J. Siracuse Tags: IP: Interactive Poster Session Source Type: research
Adherence to lipid management guidelines is associated with lower mortality and major adverse limb events in patients undergoing revascularization for chronic limb-threatening ischemia
The 2013 American College of Cardiology/American Heart Association lipid management guidelines recommend high-intensity statins for all patients ≤75 years old with chronic limb-threatening ischemia (CLTI) and moderate-intensity statins for CLTI patients>75 years old without contraindications or on dialysis, but these recommendations are based primarily on coronary and stroke data. We aimed to validate these guidelines in patients with CLTI and to assess current adherence to these recommendations.
Source: Journal of Vascular Surgery - May 12, 2017 Category: Surgery Authors: Thomas F.X. O'Donnell, Sarah E. Deery, Jeremy D. Darling, Katie E. Shean, Murray A. Mittleman, Gabrielle N. Yee, Matthew R. Dernbach, Marc L. Schermerhorn Source Type: research
Adherence to Lipid Management Guidelines and Outcomes in Patients Undergoing Revascularization for Chronic Limb-Threatening Ischemia
The 2013 American College of Cardiology/American Heart Association Updated Practice Guidelines recommend the use of high-dose statins in all patients75 years without contraindications or on hemodialysis, but these recommendations are based primarily on stroke and coronary data. We aimed to validate these guidelines in patients with CLTI and to assess current adherence to these recommendations.
Source: Journal of Vascular Surgery - February 22, 2017 Category: Surgery Authors: Thomas Fx O'Donnell, Sarah E. Deery, Jeremy D. Darling, Katie E. Shean, Murray A. Mittleman, Gabrielle N. Yee, Matthew R. Dernbach, Marc L. Schermerhorn Tags: Abstract from the 2017 Society for Clinical Vascular Surgery Annual Meeting Source Type: research
Increased Stroke Rate in Medically Managed Carotid Stenosis Patients
Since the time of the Asymptomatic Carotid Artery Stenosis (ACAS) trial, medical management of carotid stenosis has improved significantly. With the widespread use of antiplatelet agents and statins, it is no longer clear that patients with 60% internal carotid artery (ICA) stenosis will benefit from carotid endarterectomy (CEA). The Vascular Quality Initiative registry has shown that there are wide practice variations across the country regarding the degree of stenosis that prompts consideration for surgical intervention.
Source: Journal of Vascular Surgery - December 20, 2016 Category: Surgery Authors: Mary Hunter Benton, Luckett J. Daniel, Jason P. Fine, William A. Marston, Katharine L. McGinigle Tags: Abstract from the 2017 Southern Association for Vascular Surgery Annual Meeting Source Type: research
Effects of Statins on Early and Late Clinical Outcomes of Carotid Endarterectomy and the Rate of Post-Carotid Endarterectomy Restenosis
Statins have no effect on post-carotid endarterectomy (CEA) restenosis but are associated with decreased death rates in patients with diabetes trending to lower both death and stroke rates in diabetic patients with hypercholesterolemia.
Source: Journal of Vascular Surgery - November 22, 2015 Category: Surgery Authors: A.F. AbuRahma, M. Srivastava, P.A. Stone Tags: Abstract Source Type: research
Long-term Mortality in Patients with Asymptomatic Carotid Stenosis: Implications for Statin Therapy
Recent studies with asymptomatic carotid patients on best medical management have shown that the annual risk of stroke has decreased to approximately 1%. There is no evidence that a similar decrease in mortality has occurred. In addition, the intensity of statin therapy for these patients has not yet been determined. The aims of this review were to determine (a) the reported long-term all-cause and cardiac-related mortality in patients with asymptomatic carotid stenosis (ACS)>50%, (b) whether there has been a decrease in mortality in recent years, (c) the available methods of mortality risk stratification, and (d) whether ...
Source: Journal of Vascular Surgery - October 23, 2015 Category: Surgery Authors: A. Giannopoulos, S. Kakkos, A. Abbott, A.R. Naylor, T. Richards, D.P. Mikhailidis, G. Geroulakos, A.N. Nicolaides Tags: Selected abstract from the November issue of the European Journal of Vascular and Endovascular Surgery Source Type: research
