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Hyperdense Artery Signs—Potential Value in Cerebellar Stroke
I read with great interest the article “Factors Associated with the Misdiagnosis of Cerebellar Infarction” by Masuda et al. Cerebellar strokes are of clinical importance because they can have devastating consequences such as herniation, death, and coma. Furthermore, if diagnosed in time, thrombolytic therapy may be beneficial in selected cases. In their article, the authors state that 75% of the misdiagnosed patients were initially screened with nonenhanced cranial computed tomography (NECCT) that yielded normal results. I would like to present a case that demonstrates a possibility to increase the diagnostic accuracy of NECCT.
Source: Journal of Stroke and Cerebrovascular Diseases - March 5, 2014 Category: Neurology Authors: Ulf R. Jensen-Kondering Tags: Letter to the Editor Source Type: research

Modest Association between the Discharge Modified Rankin Scale Score and Symptomatic Intracerebral Hemorrhage after Intravenous Thrombolysis
Thirty- and 90-day modified Rankin Scale (mRS) scores are used to monitor adverse outcome or symptomatic intracerebral hemorrhage (sICH) in ischemic stroke patients after intravenous (IV) thrombolytic therapy. Discharge mRS scores are more readily available and could serve as a proxy for 30- or 90-day mRS data. Our goal was to evaluate agreement between the discharge mRS score and sICH. Additionally, we tested for correlations between the discharge mRS score and 8 clinical scores developed to predict sICH or adverse outcomes based on 90-day mRS data.
Source: Journal of Stroke and Cerebrovascular Diseases - December 22, 2014 Category: Neurology Authors: David Asuzu, Karin Nystrom, Hardik Amin, Joseph Schindler, Charles Wira, David Greer, Nai Fang Chi, Janet Halliday, Kevin N. Sheth Source Type: research

In Vitro Evaluation of Focused Ultrasound-Enhanced TNK-Tissue Plasminogen Activator-Mediated Thrombolysis
The low and incomplete recanalization performance of thrombolytic therapy in patients with acute ischemic stroke has created the need to use focused ultrasound (FUS) energy as a way to enhance thrombolysis efficiency (sonothrombolysis). Using an in vitro flow model, the role of various parameters involved in FUS-enhanced tenecteplase (TNK-tPA [tissue plasminogen activator])-mediated thrombolysis was evaluated.
Source: Journal of Stroke and Cerebrovascular Diseases - May 1, 2016 Category: Neurology Authors: Nikolaos Papadopoulos, Christakis Damianou Source Type: research

The Enhancing Effect of Focused Ultrasound on TNK-Tissue Plasminogen Activator-Induced Thrombolysis Using an In Vitro Circulating Flow Model
The limited efficacy of thrombolytic therapy in patients with ischemic stroke has created the need to use focused ultrasound (FUS) energy as a way to enhance thrombolysis efficacy (sonothrombolysis). Using an in vitro circulating flow model, we evaluated the role of physical parameters on tenecteplase (TNK-tPA)-mediated thrombolysis.
Source: Journal of Stroke and Cerebrovascular Diseases - September 1, 2016 Category: Neurology Authors: Nicos Papadopoulos, Christos Yiallouras, Christakis Damianou Source Type: research

Angiogram-negative subarachnoid hemorrhage after intravenous thrombolysis in a patient with acute ischemic stroke
We describe a patient with SAH immediately after thrombolytic therapy.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2017 Category: Neurology Authors: Kyung-Hee Cho, Jae-Gyum Kim, Sungwook Yu, Kyung-Hee Cho Source Type: research

Intracranial Aneurysms After Intravenous Thrombolysis in Patient with Atrial Myxoma: A Case Study
We administered intravenous thrombolytic therapy to a 51-year-old female patient with a 101-min stroke onset. The patient was unconscious during the manifestation of symptoms. Computed tomography angiography examination of the intracranial artery at the time of admission suggested that the left middle cerebral artery was occluded. The patient regained consciousness after the intravenous thrombolytic treatment was administered. On an urgent cerebral angiography, it was revealed that the recanalization of the left middle cerebral artery was successful.
Source: Journal of Stroke and Cerebrovascular Diseases - March 23, 2020 Category: Neurology Authors: Zhizhang Li, Xushen Xu, Liang Hu, Hongxian Sun, Yunhua Yue Tags: Case Report Source Type: research

Factors Associated with Pre-Hospital Delay and Intravenous Thrombolysis in China
Pre-hospital delay was a critical factor affecting stroke patients receiving intravenous thrombolytic therapy. The aim of this study was to explore the factors associated with pre-hospital delay and thrombolysis in China.
Source: Journal of Stroke and Cerebrovascular Diseases - May 15, 2020 Category: Neurology Authors: Yafang Zhu, Xia Zhang, Shoujiang You, Xiaowei Cao, Xuan Wang, Wenjie Gong, Yan Qin, Xiaojun Huang, Yongjun Cao, Rongfang Shi Source Type: research

Changes in Informed Consent Policy and Treatment Delays in Stroke Thrombolysis
The efficacy of thrombolytic therapy with tissue plasminogen activator (tPA) is highly time dependent. Although clinical guidelines do not recommend written informed consent as it may cause treatment delays, local policy can supersede and require it. From 2014 to 2017, three out of five public hospitals in Singapore changed from written to verbal consent at different time points. We aimed to examine the association of hospital policy changes regarding informed consent on door-to-needle (DTN) times.
Source: Journal of Stroke and Cerebrovascular Diseases - December 19, 2020 Category: Neurology Authors: Hanzhang Xu, Deidre Anne De Silva, Fung Peng Woon, Marcus Eng Hock Ong, David B. Matchar, Janet Prvu Bettger, Daniel T. Laskowitz, Ying Xian Source Type: research

Endovascular Treatment of Chronic, Recurrent Headache Secondary to Chronic Cerebral Venous Sinus Thrombosis
We report 2 cases of chronic superior sagittal sinus thrombosis causing isolated intracranial hypertension. The patients were treated with intrasinus thrombolytic therapy.
Source: Journal of Stroke and Cerebrovascular Diseases - May 30, 2013 Category: Neurology Authors: Xin-Bin Guo, Lai-Jun Song, Sheng Guan Tags: Case Reports Source Type: research

Beating the Clock: Time Delays to Thrombolytic Therapy with Advanced Imaging and Impact of Optimized Workflow
This study is to assess the time delay while using this scanner compared with our 64-slice scanner.
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2015 Category: Neurology Authors: Santanu Chakraborty, James Ross, Mathew J. Hogan, Dar Dowlatshahi, Grant Stotts Source Type: research

Literature Review and Case Report of Intravenous Thrombolysis in Acute Cerebral Infarction Attributed to Cervical Arterial Dissection
Acute cerebral infarction (ACI) caused by cervical arterial dissection (CAD) is a rare clinical disease. Therapeutic approaches include anticoagulant therapy, antiplatelet aggregation, and thrombolytic therapy. Currently, anticoagulant therapy or antiplatelet aggregation is the primary choice, whereas the thrombolytic therapy is still controversial. In this article, we report a patient with ACI caused by right CAD, which led to a compensatory increase in blood supply to the right middle cerebral artery through the anterior communicating artery.
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2015 Category: Neurology Authors: Zhihui Yan, Tianxia Yu, Ying Wang, Min Wang, Hui Liang Tags: Case Report Source Type: research

Neurovascular unit protection using nitroxide radicals-containing nanoparticles (TEMPO-RNP) for cerebral ischemia-reperfusion injury
【Purpose】Reperfusion injury after thrombolytic therapy or mechanical thrombectomy would adverse neurological outcome. Generation of reactive oxygen species (ROS) due to reperfusion is relevant for aggravation. The development of drug therapy for scavenging free radical is expected to lead to bet ter neurological prognosis. We developed a new core- shell type nanoparticle, RNP (radical containing nanoparticle), which consists of micelle containing 4-amino-TEMPO. The purpose of this study is to evaluate an efficacy of intra-arterial injection of RNP after reperfusion using tMCAO mice model.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2017 Category: Neurology Authors: Hisayuki Hosoo, Aiki Marushima, Yukio Nagasaki, Aki Hirayama, Hiromu Ito, Ami Niwano, Hideo Tsurushima, Wataro Tsuruta, Kensuke Suzuki, Tetsuya Yamamoto, Akira Matsumura Source Type: research

Spinal cord injury misdiagnosed as cerebral infarction and given thrombolytic therapy: A case report
【Background】Spinal Cord Injury Without Radiographic Abnormality (SCIWORA) covers a broad spectrum of neurological deficits, which can be confused with cerebral infarction when patients present with hemiparesis and a history of minor injury.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2017 Category: Neurology Authors: Jie Yang, Jing Hang, Junshan Zhou, Yingdong Zhang Source Type: research

Isosteviol Sodium Protects Against Permanent Cerebral Ischemia Injury in Mice via Inhibition of NF- κB–Mediated Inflammatory and Apoptotic Responses
Isosteviol sodium (STVNa) has been reported to have neuroprotective effects against ischemia/reperfusion (I/R) injury in rats. Furthermore, recanalization treatments, including thrombolytic therapy, have several limitations. Excessive inflammation and apoptosis contribute to the pathogenesis of ischemic brain damage. Nuclear factor kappa-light-chain-enhancer of activated B cells (NF- κB) is critical to these processes and is associated with cerebral ischemia. Therefore, we studied the potential therapeutic effects and mechanisms of STVNa on permanent cerebral ischemia in mice.
Source: Journal of Stroke and Cerebrovascular Diseases - August 4, 2017 Category: Neurology Authors: Hao Zhang, Xiaoou Sun, Yanxiang Xie, Jie Zan, Wen Tan Source Type: research

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