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Source: Journal of Stroke and Cerebrovascular Diseases
Therapy: Thrombolytic Therapy
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Total 78 results found since Jan 2013.
Drip-and-Ship Thrombolytic Therapy for Acute Ischemic Stroke
Neuroendovascular therapy is a common treatment for patients with acute ischemic stroke of the anterior circulation who fail to respond to recombinant tissue plasminogen activator. However, although most hospitals can provide recombinant tissue plasminogen activator therapy, many cannot perform neuroendovascular therapy. Thus, use of a drip-and-ship treatment-liaison system allowing recombinant tissue plasminogen activator-treated patients to be transferred to facilities offering neuroendovascular therapy is important.
Source: Journal of Stroke and Cerebrovascular Diseases - September 1, 2017 Category: Neurology Authors: Ichiro Deguchi, Satoko Mizuno, Shinya Kohyama, Norio Tanahashi, Masaki Takao Source Type: research
Acute Stroke Patients With Mild-to-Moderate Pre-existing Disability Should Be Considered for Thrombolysis Treatment
Thrombolytic therapy in patients with pre-existing disability presenting with acute ischemic stroke (AIS) is controversial because of concerns regarding poor outcomes and futility of treatment. We hypothesized that a similar proportion of patients with and without pre-existing disability would return to their premorbid functional status following thrombolysis.
Source: Journal of Stroke and Cerebrovascular Diseases - July 20, 2018 Category: Neurology Authors: Wenwen Zhang, Skye Coote, Tanya Frost, Helen M. Dewey, Philip M.C. Choi Source Type: research
Efficacy of Tirofiban Administered at Different Time Points after Intravenous Thrombolytic Therapy with Alteplase in Patients with Acute Ischemic Stroke
To evaluate the efficacy of tirofiban administered at different time points within 24 hours of intravenous thrombolysis with alteplase in acute ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - January 14, 2019 Category: Neurology Authors: Jin Liu, Qiuyan Shi, Yuan Sun, Jingyuan He, Bin Yang, Chunyang Zhang, Rui Guo Source Type: research
Even Faster Door-to-Alteplase Times and Associated Outcomes in Acute Ischemic Stroke
We report a single-center, retrospective assessment of the safety and efficacy of alteplase treatment within 45 minutes. Methods: Five hundred and eighty-six patients were treated with alteplase in our emergency departments (EDs) between January 2014 and October 2016; 368 patients were included for analysis.
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2019 Category: Neurology Authors: Sarah Jung, Jamie M. Rosini, Jason T. Nomura, Richard J. Caplan, Jonathan Raser-Schramm Source Type: research
Response to “Measuring the Optic Nerve Sheath Diameter with Ultrasound in Acute Middle Cerebral Artery Stroke Patients”: For Application to Long-Duration Spaceflight (LDSF)
We thank the authors of the study for their contribution to literature and their insights into the utilisation of optic nerve sheath diameter (ONSD) measurements with regards to therapeutic efficacy of thrombolytic therapy (TT) and identification of complications in populations post-MCA stroke. We would like to introduce the discussion of potential translational benefits of this methodology to the field of long-duration spaceflight (LDSF).
Source: Journal of Stroke and Cerebrovascular Diseases - January 20, 2021 Category: Neurology Authors: Chloe A. Mohanadass, Lauren E. Church Tags: Letter to the Editor Source Type: research
Reply to: Response to “measuring the optic nerve sheath diameter with ultrasound in acute middle cerebral artery stroke patients”: For application to Long-Duration Spaceflight (LDSF)
We thank Mohanadass and Church for their interest in using Optic Nerve Sheath Diameter (ONSD) measurements in Acute Middle Cerebral Artery (MCA) stroke patients to evaluate the effect of thrombolytic therapy and identify high-risk patients.1
Source: Journal of Stroke and Cerebrovascular Diseases - January 23, 2021 Category: Neurology Authors: Seda G üzeldağ, Gökhan Yılmaz Tags: Letter to the Editor Source Type: research
Safety and outcomes of intravenous thrombolytic therapy in ischemic stroke patients with COVID-19: CASCADE initiative
There is little information regarding the safety of intravenous tissue plasminogen activator (IV-tPA) in patients with stroke and COVID-19.
Source: Journal of Stroke and Cerebrovascular Diseases - September 19, 2021 Category: Neurology Authors: Payam Sasanejad, Leila Afshar Hezarkhani, Shahram Arsang-Jang, Georgios Tsivgoulis, Abdoreza Ghoreishi, Barlinn Kristian, Jan Rahmig, Mehdi Farhoudi, Elyar Sadeghi Hokmabadi, Afshin Borhani-Haghighi, Payam Sariaslani, Athena Sharifi-Razavi, Kavian Ghandeh Source Type: research
Prediction of Intracerebral Hemorrhage After Endovascular Treatment of Acute Ischemic Stroke: Combining Quantitative Parameters on Dual-Energy CT with Clinical Related Factors
At present, intravenous thrombolysis and endovascular therapy are the two main treatment methods of acute ischemic stroke (AIS). The application of intravenous thrombolytic therapy is limited by strict time window restrictions, while endovascular therapy significantly increases the rate of revascularization of arterial occlusion and can improve the clinical prognosis of patients, so it is increasingly applied in clinical practice.1 Despite advances in patient selection for reperfusion therapy for AIS, intracerebral hemorrhage (ICH) remains a serious potential complication, and often occurred within 72 h after surgery.
Source: Journal of Stroke and Cerebrovascular Diseases - July 27, 2021 Category: Neurology Authors: Ling Li, Mingyue Huo, Tianzi Zuo, Yuhang Wang, Yingmin Chen, Yunfeng Bao Source Type: research
Early Access to a Neurologist Reduces the Rate of Missed Diagnosis in Young Strokes
Conclusions: Young adults with ischemic stroke seen at hospitals with a neurology residency had a lower missed diagnosis rate. The presence of an EM resident or a neurology teaching program was associated with a greater use of acute stroke therapies. These results support initiatives to triage young adults with suspected acute stroke to hospitals with access to neurologic expertise in the emergency department.
Source: Journal of Stroke and Cerebrovascular Diseases - February 18, 2013 Category: Neurology Authors: Wazim Mohamed, Pratik Bhattacharya, Seemant Chaturvedi Tags: Original Articles Source Type: research
Using Routine Data for Quality Assessment in NeuroNet Telestroke Care
Background: Systematic clinical trials are often unavailable to evaluate and optimize operational telestroke networks. In a complementary approach, readily available routine clinical data were analyzed in this study to evaluate the effect of a telestroke network over a 4-year period.Methods: Routine clinical data from the HELIOS hospital information system were compared before and after implementation of the NeuroNet concept, including neurologic acute stroke teleconsultations, standard operating procedures, and peer review quality management in 3 hospital cohorts: 5 comprehensive stroke centers, 5 NeuroNet hospitals, and ...
Source: Journal of Stroke and Cerebrovascular Diseases - February 24, 2012 Category: Neurology Authors: Stephan Theiss, Franziska Günzel, Anna Storm, Patrick Hausn, Stefan Isenmann, Joachim Klisch, Guntram W. Ickenstein, NeuroNet network Tags: Original Articles Source Type: research
Poor Awareness of Stroke—A Hospital-Based Study from South India: An Urgent Need For Awareness Programs
Background: Stroke treatment has reached a new benchmark with thrombolytic therapy. However, India has witnessed a tremendous increase in morbidity and mortality of stroke over the past few decades. The prime deciding factor is initiation of treatment within the time window, which requires early recognition of stroke symptoms. We wished to analyze the lacunae in the stroke knowledge in our population. This hospital-based study assessed awareness of the public regarding stroke.Methods: Two trained medical students interviewed accompanying relatives using a structured questionnaire. Data were analyzed using Statistical Packa...
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2014 Category: Neurology Authors: Bindu Menon, Jatla J. Swaroop, Haripuram K.R. Deepika, Jyothi Conjeevaram, K. Munisusmitha Tags: Original Articles Source Type: research
Specific Needs for Telestroke Networks for Thrombolytic Therapy in Japan
This study uncovered that many Japanese stroke hospitals, especially low-volume facilities located in rural areas, do not perform IV tPA therapy in 24/7 fashion and telestroke support to these hospitals may be highly effective compared with the drip-and-ship network in an underserved area.
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2013 Category: Neurology Authors: Takeshi Imai, Kenzo Sakurai, Yuta Hagiwara, Heisuke Mizukami, Yasuhiro Hasegawa Tags: Original Articles Source Type: research
Hemorrhagic Transformation during Thrombolytic Therapy and Reperfusion: Effects of Age, Blood Pressure, and Matrix Metalloproteinases
Background: Despite the increasing use of thrombolytic therapy for acute ischemic stroke, hemorrhagic transformation remains a significant complication. Transformation appears to occur more frequently with age, diabetes, and hypertension, but clinical data are mixed. In addition to risk factors, matrix metalloproteinase expression mediates hemorrhage. We sought to test the effects of age, hypertension, and matrix metalloproteinases during recombinant tissue plasminogen activator (rt-PA) treatment in a standard model of filament occlusion of the middle cerebral artery.Methods: We compared young and aged rats who were geneti...
Source: Journal of Stroke and Cerebrovascular Diseases - March 4, 2013 Category: Neurology Authors: Patrick D. Lyden Tags: Original Articles Source Type: research
Emergent Angioplasty and Stent Placement Recanalization Without Thrombolysis in Acute Middle Cerebral Artery Occlusions
This study evaluated the feasibility, efficacy, and safety of intracranial artery recanalization for acute middle cerebral artery (MCA) occlusion using emergent angioplasty and stent placement without thrombolysis. All patients from a retrospectively collected database who met the inclusion criteria and were treated with an intracranial stent for acute MCA occlusion were included. Treatment comprised angioplasty and stenting without interventional thrombolytic therapy. Recanalization was assessed by angiography immediately after stent placement based on the Thrombolysis in Myocardial Infarction (TIMI) score. Complications ...
Source: Journal of Stroke and Cerebrovascular Diseases - December 12, 2011 Category: Neurology Authors: Xin-Bin Guo, Lai-Jun Song, Sheng Guan Tags: Original Articles Source Type: research
An Unusual Cause of Ischemic Stroke with Successful Thrombolysis
A 63-year-old woman was admitted because of sudden ischemic hemyplegia promptly cleared up by intravenous (IV) recombinant tissue plasminogen activator. On subsequent 2-dimensional echocardiogram, we observed an extremely mobile homogeneous mass attached by a short stalk to ventricular insertion of anterolateral papillary muscle chordae tendineae. The mass was surgically removed. Gross anatomy showed a mass with a gelatinoids appearance formed on histology by a lining of hyperplastic endocardial cells covering a hypocellular stroma consistent with papillary fibroelastoma. Given the prompt clinical improvement with IV throm...
Source: Journal of Stroke and Cerebrovascular Diseases - September 4, 2013 Category: Neurology Authors: Giovanni Corrado, Paolo Panisi, Nicoletta Checcarelli, Luciana Ambrosiani Tags: Case Reports Source Type: research
