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Source: Journal of Stroke and Cerebrovascular Diseases
Therapy: Statin Therapy
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Total 37 results found since Jan 2013.
Demographic and Clinical Predictors of Leptomeningeal Collaterals in Stroke Patients
Background: Leptomeningeal collaterals improve outcome after stroke, including reduction of hemorrhagic complications after thrombolytic or endovascular therapy, smaller infarct size, and reduction in symptoms at follow-up evaluation. The purpose of this study was to determine the demographic and clinical variables that are associated with a greater degree of cerebral collaterals.Methods: Clinical data of patients presenting with M1 occlusions of the middle cerebral artery (MCA) and associated computed tomography angiography studies after admission from 3 separate institutions were retrospectively compiled (n = 82). Occl...
Source: Journal of Stroke and Cerebrovascular Diseases - August 4, 2014 Category: Neurology Authors: Nitin Malik, Qinghua Hou, Achala Vagal, James Patrie, Wenjun Xin, Patrik Michel, Ashraf Eskandari, Tudor Jovin, Max Wintermark Tags: Original Articles Source Type: research
Subsequent Vascular Events after Ischemic Stroke: The Japan Statin Treatment Against Recurrent Stroke—Longitudinal
We undertook a multicenter cohort observational study to investigate the frequency and type of subsequent vascular events after an ischemic stroke and to compare the rates of vascular events between patients with and without hyperlipidemia.
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2014 Category: Neurology Authors: Eiichi Nomura, Akifumi Suzuki, Isao Inoue, Jyoji Nakagawara, Kazuo Takahashi, Tetsuya Takahashi, Yasuhiro Manabe, Chiaki Yokota, Kazunori Okada, Tetsuhiro Nishihara, Yasumasa Yamamoto, Koichi Noda, Shinichi Takahashi, Setsuro Ibayashi, Makoto Takagi, Kazu Source Type: research
The Effects of Previous Statin Treatment on Plasma Matrix Metalloproteinase-9 Level in Chinese Stroke Patients Undergoing Thrombolysis
It is unclear whether previous statin therapy influences the prognosis, hemorrhagic transformation, and plasma matrix metalloproteinases (MMP)-9 levels in Chinese stroke patients receiving intravenous thrombolysis. We conduct a prospective cohort study of 193 patients treated with intravenous thrombolysis. All the enrolled patients were divided into 2 groups (the control group and the statin group), according to the previous history of statin use. The plasma MMP-9 levels were detected before and at 6 hours, 12 hours, 24 hours, and 72 hours after intravenous thrombolysis.
Source: Journal of Stroke and Cerebrovascular Diseases - October 11, 2014 Category: Neurology Authors: Hong-Dong Zhao, Ying-Dong Zhang Source Type: research
Inpatient Statin Use Is Associated with Decreased Mortality of Acute Stroke Patients with Very Low Low-Density Lipoprotein Cholesterol
To investigate the potential benefits of inpatient statin therapy on mortality of acute stroke patients with very low admission low-density lipoprotein cholesterol (LDL-C) level (
Source: Journal of Stroke and Cerebrovascular Diseases - August 23, 2015 Category: Neurology Authors: Bo Song, Yilong Wang, Xingquan Zhao, Liping Liu, Chunxue Wang, Anxin Wang, Wanliang Du, Yongjun Wang, Yuming Xu Source Type: research
Statin Medication Use and Nosocomial Infection Risk in the Acute Phase of Stroke
Statins have immunomodulatory and peripheral anti-inflammatory properties that are independent of their lipid-lowering action. Whether these properties reduce the risk for developing poststroke infection is debated in clinical literature. We estimated the risk for developing nosocomial poststroke infection based on statin exposure in patients aged 18 or older hospitalized for ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - June 8, 2016 Category: Neurology Authors: Douglas L. Weeks, Christopher L. Greer, Megan N. Willson Source Type: research
Lipoprotein-associated Phospholipase A2 during the Hyperacute Stage of Ischemic and Hemorrhagic Strokes
Conclusions: Lp-PLA2 mass is higher in ICH compared with ischemic stroke during the hyperacute stage. Lp-PLA2 activity is associated with stroke volume in ICH but not in ischemic stroke. This suggests that Lp-PLA2 mass and activity could provide different information in the hyperacute stage of stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2014 Category: Neurology Authors: Charlotte Rosso, David Rosenbaum, Christine Pires, Corinne Cherfils, Nabil Koujah, Fouzi Mestari, Emeline Gillet, Sophie Crozier, Mélika Sahli-Amor, Yves Samson, Dominique Bonnefont-Rousselot, Randa Khani-Bittar Tags: Original Articles Source Type: research
Early Hospitalization of Patients with TIA: A Prospective, Population-based Study
Conclusions: These findings may help clinicians to estimate the TIA prognosis in patients who were hospitalized early with TIA.
Source: Journal of Stroke and Cerebrovascular Diseases - November 19, 2012 Category: Neurology Authors: Mohamed Al-Khaled, Jürgen Eggers Tags: Original Articles Source Type: research
Cerebral Infarction in a Case of Parry-Romberg Syndrome
Our objective is to report a rare coexistence of Parry-Romberg disease and ischemic stroke. Here, we report the case of a 34-year-old woman with Parry-Romberg syndrome who developed cerebral infarction. This patient developed sudden left-sided weakness and was admitted to our hospital. Magnetic resonance imaging revealed acute cerebral infarction in the posterior limb of the right internal capsule. The patient had been diagnosed with Parry-Romberg syndrome at the age of 12, and she had a history of migraine without aura. Transesophageal echocardiography revealed a patent foramen ovale, but no atrial septal aneurysm or deep...
Source: Journal of Stroke and Cerebrovascular Diseases - May 9, 2013 Category: Neurology Authors: Yuji Tomizawa, Ryota Tanaka, Kiyoshi Sekiguchi, Yutaka Oji, Yasutaka Tanaka, Kazuo Yamashiro, Nobutaka Hattori Tags: Case Reports Source Type: research
Long-term Improvement in Outcome After Intracerebral Hemorrhage in Patients Treated with Statins
Conclusions: Statin use is associated with improved long-term outcome at 12 months after ICH. This finding supports previous clinical studies that have shown the short-term benefits of statin therapy. In addition, this study correlates with animal studies supporting the possible long-term recovery benefits of statins.
Source: Journal of Stroke and Cerebrovascular Diseases - July 17, 2013 Category: Neurology Authors: Jonathan Winkler, John Paul Shoup, Alexandra Czap, Ilene Staff, Gilbert Fortunato, Louise D. McCullough, Lauren H. Sansing Tags: Original Articles Source Type: research
Statins and Intracerebral Hemorrhage: Potential Mechanisms
In a recent publication, Tapia Pérez et al1 have argued, based on some of the previous meta-analyses, that the risk for statin-induced intracerebral hemorrhage (ICH) has been refuted. However, this is a premature and somewhat misleading conclusion, as whether high-dose statin therapy can elicit ICH remains to be a subject of contention among researchers and clinicians.2 In fact, according to the most recent guidelines by the American Stroke Association for the management of ICH, the question of whether statin therapy should be continued in patients remains elusive.
Source: Journal of Stroke and Cerebrovascular Diseases - December 11, 2015 Category: Neurology Authors: Shahram Eisa-Beygi, Suzan El-Rass Tags: Letter to the Editor Source Type: research
Low Testosterone Level as a Predictor of Poststroke Emotional Disturbances: Anger Proneness and Emotional Incontinence
The role of sex hormones in poststroke mood and emotional disturbances is unclear. We aimed to evaluate the impact of sex hormones on poststroke emotional disturbance, especially anger proneness (AP) and emotional incontinence (EI). We also investigated whether statins, which are widely used for stroke prevention, affect sex hormone levels or the presence of poststroke AP/EI based on the hypothesis that intensive treatment with statins would inhibit the synthesis of cholesterol, the preferred substrate of testosterone.
Source: Journal of Stroke and Cerebrovascular Diseases - September 6, 2018 Category: Neurology Authors: Mun Hee Choi, Tae Sung Lim, Bok Seon Yoon, Keoung Sun Son, Ji Man Hong, Jin Soo Lee Source Type: research
Efficacy and Safety of PCSK9 Inhibitors in Stroke Prevention
Proprotein convertase subtilisin/kexin type 9 (PCSK9) interacts with the low-density lipoprotein (LDL) receptor and, by enhancing its degradation, has a pivotal role in the regulation of cholesterol homeostasis. Two fully humanized monoclonal antibodies targeting PCSK9, evolocumab and alirocumab, are available for clinical use. PCSK9 inhibitors reduce LDL-C 30% more than ezetimibe and 60% more than placebo when added to statins. This reduction in LDL-C is accompanied by a decrease in the risk of major cardiovascular and cerebrovascular events.
Source: Journal of Stroke and Cerebrovascular Diseases - August 24, 2021 Category: Neurology Authors: Bayan Moustafa, Fernando D Testai Tags: Review Article Source Type: research
Statin Use and Risk of Cerebral Aneurysm Rupture: A Hospital-based Case–control Study in Japan
Conclusions: This observation from a hospital-based case-control study in Japan suggested that there is inverse relationship between use of statins and cerebral aneurysm rupture. Future clinical studies are needed.
Source: Journal of Stroke and Cerebrovascular Diseases - May 21, 2013 Category: Neurology Authors: Yayoi Yoshimura, Yoshitaka Murakami, Makoto Saitoh, Toshihiro Yokoi, Tomohiro Aoki, Katsuyuki Miura, Hirotsugu Ueshima, Kazuhiko Nozaki, SSS Research Group Tags: Original Articles Source Type: research
Rosuvastatin Ameliorates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Superoxide Formation and Nuclear Factor-Kappa B Activation in Rats
Conclusions: The present study demonstrates that rosuvastatin pretreatment ameliorates EBI after SAH through the attenuation of oxidative stress and NF-κB–mediated inflammation.
Source: Journal of Stroke and Cerebrovascular Diseases - February 14, 2014 Category: Neurology Authors: Ken Uekawa, Yu Hasegawa, Mingjie Ma, Takashi Nakagawa, Tetsuji Katayama, Daisuke Sueta, Kensuke Toyama, Keiichiro Kataoka, Nobutaka Koibuchi, Takayuki Kawano, Jun-ichi Kuratsu, Shokei Kim-Mitsuyama Tags: Original Articles Source Type: research
