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Ischemic stroke is a potential complication of uncontrolled inflammation in mevalonate kinase deficiency – A case report
Mevalonate kinase deficiency (MKD) is an autosomal recessive monogenic autoinflammatory disease (AID) characterized by recurrent antigen-independent systemic inflammation attacks, interleukin-1beta hypersecretion, fever and pain.1 Neurological manifestations include headaches, fatigue, retinal dystrophy, ataxia and development delay.2
Source: Journal of Stroke and Cerebrovascular Diseases - October 12, 2022 Category: Neurology Authors: Justine Blais, Didier Bonneville-Roussy, Hannah Laure Elfassy, Sylvain Lanthier Tags: Case Report Source Type: research

Retinal Microvascular Abnormalities as Surrogate Markers of Cerebrovascular Ischemic Disease: A Meta-Analysis
To determine the predictive value of retinal microvascular abnormalities for cerebrovascular ischemic diseases (CVDs), we aimed to investigate the quantitative association between retinal microvascular changes and CVD subcategories: white matter hyperintensities (WMHIs), lacunar infarcts (LIs), and cerebral infarctions (CIs).
Source: Journal of Stroke and Cerebrovascular Diseases - March 20, 2018 Category: Neurology Authors: Oana M. Dumitrascu, Bart M. Demaerschalk, Cristina Valencia Sanchez, Diana Almader-Douglas, Cumara B. O'Carroll, Maria I. Aguilar, Patrick D. Lyden, Gyanendra Kumar Source Type: research

Is Management of Central Retinal Artery Occlusion the Next Frontier in Cerebrovascular Diseases?
Central retinal artery occlusion (CRAO) is a medical emergency that, if not treated, may result in irreversible loss of vision. It continues to be an important cause for acute painless loss of vision. Amaurosis fugax or “transient CRAO” has long been considered an equivalent of transient cerebral ischemic event. Animal models, in addition to data from retrospective and randomized clinical studies, provide valuable insights into the time interval for irreversible retinal ischemia. Subset analyses from 2 large st udies of patients with CRAO show benefit from treatment with thrombolysis within 6 hours from symptoms onset.
Source: Journal of Stroke and Cerebrovascular Diseases - July 27, 2018 Category: Neurology Authors: Kaustubh Limaye, Michael Wall, Sami Uwaydat, Sheharayar Ali, Amir Shaban, Sami Al Kasab, Harold Adams Source Type: research

A 23-Year-Old Woman with Sudden-Onset Blindness of the Right Eye
A 23-year-woman was presented for sudden-onset monocular blindness. Branch retinal artery occlusion in the right eye and multiple brain embolism were detected. Trousseau syndrome due to bilateral ovarian cancer was diagnosed; no embolic events were observed after anticoagulant therapy and surgical resection.
Source: Journal of Stroke and Cerebrovascular Diseases - January 9, 2019 Category: Neurology Authors: Yosuke Takeuchi, Keiichi Nakahara, Makoto Nakajima, Yasuteru Inoue, Riyo Matsumura, Munekage Yamaguchi, Hidetaka Katabuchi, Yukio Ando Tags: Case Report Source Type: research

Alternating Amaurosis Fugax in Trousseau Syndrome: A Case Report
Amaurosis fugax (AmF) is defined as transient monocular visual loss secondary to retinal ischemia. In most patients presenting with AmF, the attack of visual loss occurs in the same eye. A 64-year-old woman experienced transient visual loss in her right eye. Three days after that, an attack happened on the left side. In total, she had 5 episodes of AmF in 2 months. AmF occurred on both sides at different times, and so may be referred to as “Alternating AmF”. Diffusion-weighted magnetic resonance imaging showed high-intensity lesions in various parts of brain, and laboratory examination revealed elevated D-dimer and ovarian tumor marker.
Source: Journal of Stroke and Cerebrovascular Diseases - May 12, 2019 Category: Neurology Authors: Katsuhiko Kunitake, Ryosuke Inagaki, Soma Furukawa, Satoshi Kitagawa, Hidenori Oguchi, Yasuhiro Ito Tags: Case Report Source Type: research

Controversies on the Recommended Treatment for Central Retinal Artery Occlusion
In a recent article, Mac Grory et al.1 described the structural and functional retinal imaging modalities in central retinal artery occlusion (CRAO). They have also suggested that thrombolysis is emerging as a compelling therapeutic approach for CRAO treatment, and should be administered shortly after the onset of visual loss to induce recanalisation of the occluded retinal arteries and reperfusion of the ischemic retina before retinal cell death. Importantly, there is considerable variability in CRAO management patterns among practitioners, institutions, and subspecialty groups.
Source: Journal of Stroke and Cerebrovascular Diseases - July 14, 2021 Category: Neurology Authors: Raimo Tuuminen, Asaf Achiron, Piotr Kanclerz Tags: Letter to the Editor Source Type: research

Response by Mac Grory et  al. to Letter regarding “Structural and Functional Imaging of the Retina in Central Retinal Artery Occlusion – Current Approaches and Future Directions”
We wish to thank Drs. Tuuminen, Achiron and Kanclerz for the interest in our paper and for the opportunity to address several entrenched misconceptions about the treatment of central retinal artery occlusion (CRAO). In 2015, Schrag et  al.1 published a subject level meta-analysis concerning visual outcomes in patients with CRAO who were untreated, treated with thrombolysis or treated with a variety of conservative therapies (anterior chamber paracentesis, ocular massage and/or hemodilution). An important innovation in this work was the use of a simple, reproducible definition of visual recovery as the attainment of a fina...
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2021 Category: Neurology Authors: Brian Mac Grory, Matthew Schrag, Sven Poli, Chantal Boisvert, Val érie Biousse, Wuwei Feng Source Type: research

The Hyperbaric Oxygen Therapy Protocol in Acute Central Retinal Artery Occlusion Seen within 24 Hours at a Tertiary Institution
We read with interest the research article entitled “Acute Central Retinal Artery Occlusion Seen within 24 h at a Tertiary Institution”,1 it was an original study focusing on the timing of emergency hospital attendance after acute Central Retinal Artery Occlusion (CRAO) onset from sudden vision loss. The authors were particularly concerned on th e CRAO protocol of intravenous thrombolysis and diagnostic pathway. However, as the Hyperbaric Oxygen Therapy (HBOT) practitioners running the HORA study,2–5 we are more interested in the HBOT protocol adopted in the authors’ tertiary institution, which was not mentioned in the article.
Source: Journal of Stroke and Cerebrovascular Diseases - August 13, 2021 Category: Neurology Authors: Sunny Chi Lik Au Tags: Letter to the Editor Source Type: research

Retinal artery/vein occlusion complicating SARS-CoV-2 vaccinations
Letter to the Editor
Source: Journal of Stroke and Cerebrovascular Diseases - June 26, 2022 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research

Isolated and Combined Unilateral Central Retinal Artery and Vein Occlusions After Vaccination. A Review of the Literature
Retinal artery occlusion (RAO), especially central RAO, is a sight-threatening and potentially blinding ophthalmic emergency. Recent publications reported its association with coronavirus disease 2019 (COVID-19) mRNA vaccines. Although rare, vaccines have been linked to ophthalmic complications, and it is of interest to examine the current literature on vaccine-related RAO.
Source: Journal of Stroke and Cerebrovascular Diseases - May 12, 2022 Category: Neurology Authors: Clarice, Kai-ying Su, Sunny, Chi Lik Au Tags: Short Communication Source Type: research

Vaccine-related retinal artery occlusion in adults: a review of the current literature
First of all, I am pleased to have an opportunity to discuss our recently published review on vaccine-related retinal artery occlusion (RAO) in adults.1 Publication and reporting bias are well known in medical research,2 and time lag bias is unavoidable in major public healthcare event as if COVID-19 vaccination.3 Our review clearly listed out the literature search methods on search engine and database used (MEDLINE and PubMed), keywords and MeSH terms applied (vaccine retinal artery occlusion), as well as the date of the search (10th January 2022).
Source: Journal of Stroke and Cerebrovascular Diseases - August 8, 2022 Category: Neurology Authors: Maggie Yeung, Clarice Kai-ying Su, Sunny Chi Lik Au Source Type: research

Retinal and optic nerve magnetic resonance diffusion-weighted imaging in acute non-arteritic central retinal artery occlusion
Diffusion weighted imaging hyperintensity (DWI-H) has been described in the retina and optic nerve during acute central retinal artery occlusion (CRAO). We aimed to determine whether DWI-H can be accurately identified on standard brain magnetic resonance imaging (MRI) in non-arteritic CRAO patients at two tertiary academic centers.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2022 Category: Neurology Authors: Matthew Boyko, Oana Dumitrascu, Amit M. Saindane, Joseph M. Hoxworth, Ranliang Hu, Tanya Rath, Wesley Chan, Alexis M. Flowers, Ehab Harahsheh, Parth Parikh, Omer Elshaigi, Benjamin I. Meyer, Nancy J. Newman, Val érie Biousse Source Type: research

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