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A Review on Preclinical Models of Ischemic Stroke: Insights Into the Pathomechanisms and New Treatment Strategies
CONCLUSION: There are still many inter-linked pathophysiological alterations with regards to stroke, animal models need not necessarily mimic the same conditions of stroke pathology and newer targets and therapies are the need of the hour in stroke research.PMID:34493185 | DOI:10.2174/1570159X19666210907092928
Source: Current Neuropharmacology - September 8, 2021 Category: Drugs & Pharmacology Authors: Aditya A Singh Akash Kharwar Manoj P Dandekar Source Type: research

The Role of Stem Cells in the Therapy of Stroke
CONCLUSION: Although further research in this field is required, post stroke brain recovery supported by exogenous stem cells seems to be promising future therapy revolutionizing modern neurology.PMID:34365923 | DOI:10.2174/1570159X19666210806163352
Source: Current Neuropharmacology - August 9, 2021 Category: Drugs & Pharmacology Authors: Maria Ejma Natalia Madetko Anna Brzecka Piotr Alster S ławomir Budrewicz Magdalena Koszewicz Marta Misiuk-Hoj ło Irina K Tomilova Siva G Somasundaram Cecil E Kirkland Gjumrakch Aliev Source Type: research

The Relationship of Astrocytes and Microglia with Different Stages of Ischemic Stroke
CONCLUSION: Understanding the details of astrocyte-microglia interaction processes will contribute to a better understanding of the mechanisms underlying ischemic stroke, contributing to the identification of new therapeutic interventions.PMID:37464832 | DOI:10.2174/1570159X21666230718104634
Source: Current Neuropharmacology - July 19, 2023 Category: Drugs & Pharmacology Authors: Zhen Liang Yingyue Lou Yulei Hao Hui Li Jiachun Feng Songyan Liu Source Type: research

Pharmacological interventions and rehabilitation approach for enhancing brain self-repair and stroke recovery.
Abstract Neuroplasticity is a natural process occurring in the brain for entire life. Stroke is the leading cause of long term disability and huge medical and financial problem throughout the world. Research conducted over the past decade focused mainly on neuroprotection in the acute phase of stroke while very little studies targets chronic stage. Recovery after stroke depends on the ability of our brain to reestablish structural and functional organization of neurovascular networks. Combining adjuvant therapies and drugs may enhance the repair processes and restore impaired brain functions. Currently, there are ...
Source: Current Neuropharmacology - July 24, 2019 Category: Drugs & Pharmacology Authors: Szelenberger R, Kostka J, Saluk-Bijak J, Miller E Tags: Curr Neuropharmacol Source Type: research

Angiogenesis and Blood-Brain Barrier Permeability in Vascular Remodeling after Stroke.
Abstract Angiogenesis, the growth of new blood vessels, is a natural defense mechanism helping to restore oxygen and nutrient supply to the affected brain tissue following an ischemic stroke. By stimulating vessel growth, angiogenesis may stabilize brain perfusion thereby promoting neuronal survival, brain plasticity, and neurologic recovery. However, therapeutic angiogenesis after stroke faces challenges: new angiogenesisinduced vessels have a higher than normal permeability, and treatment to promote angiogenesis may exacerbate outcome in stroke patients. The development of therapies requires elucidation of the p...
Source: Current Neuropharmacology - July 19, 2020 Category: Drugs & Pharmacology Authors: Yang Y, Torbey MT Tags: Curr Neuropharmacol Source Type: research

The Effects and Underlying Mechanisms of Cell Therapy on Blood-Brain Barrier Integrity After Ischemic Stroke.
Abstract Ischemic stroke is one of the main causes of mortality and disability worldwide. However, the efficient therapeutic strategies are still lacking. Stem/progenitor cell-based therapy, with its vigorous advantages, has emerged as a promising tool for the treatments of ischemic stroke. The mechanisms involve new neural cells and neuronal circuitry formation, antioxidation, inflammation alleviation, angiogenesis and neurogenesis promotion. In the past decades, in-depth studies have suggested that cell therapy could promote vascular stabilization and decrease blood-brain barrier (BBB) leakage after ischemic str...
Source: Current Neuropharmacology - September 13, 2020 Category: Drugs & Pharmacology Authors: Gao L, Song Z, Mi J, Hou P, Xie C, Shi J, Li Y, Manaenko A Tags: Curr Neuropharmacol Source Type: research

Targeting brain-spleen crosstalk after stroke: new insights into stroke pathology and treatment
Curr Neuropharmacol. 2021 Mar 15. doi: 10.2174/1570159X19666210316092225. Online ahead of print.ABSTRACTThe immune response following acute stroke has received great attention. The spleen is an important immune organ, and more and more studies have shown that brain-spleen crosstalk after stroke plays an important role in its development and prognosis. There are many mechanisms of spleen activation after stroke, including activation of the sympathetic nervous system, the production of chemokines, and antigen presentation in the damaged brain. The changes in the spleen after stroke are mainly reflected in morphology, changes...
Source: Current Neuropharmacology - March 17, 2021 Category: Drugs & Pharmacology Authors: Dong Han Hang Liu Yan Gao Juan Feng Source Type: research

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