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Source: Circulation Research

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Total 159 results found since Jan 2013.

High-Density Lipoprotein Carries Markers that Track with Recovery from Stroke.
Conclusions: Changes in HDL proteins during early acute phase of stroke associate with recovery. Monitoring HDL proteins may provide clinical biomarkers that inform on stroke recuperation . PMID: 32844720 [PubMed - as supplied by publisher]
Source: Circulation Research - August 25, 2020 Category: Cardiology Authors: Plubell DL, Fenton AM, Rosario S, Bergstrom P, Wilmarth PA, Clark WM, Zakai N, Quinn JF, Minnier J, Alkayed NJ, Fazio S, Pamir N Tags: Circ Res Source Type: research

MiR-18a inhibits BMP4 and HIF-1 α Normalizing Brain Arteriovenous Malformations.
Conclusions: MiR-18a may have significant clinical value in preventing, reducing and potentially reversing AVM. PMID: 32755283 [PubMed - as supplied by publisher]
Source: Circulation Research - August 4, 2020 Category: Cardiology Authors: Marín-Ramos NI, Thein TZ, Ghaghada KB, Chen TC, Giannotta SL, Hofman F Tags: Circ Res Source Type: research

CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke.
Conclusions: These results establish CD84 as a critical pathogenic effector and thus a potential pharmacological target in ischemic stroke. PMID: 32762491 [PubMed - as supplied by publisher]
Source: Circulation Research - July 29, 2020 Category: Cardiology Authors: Schuhmann MK, Stoll G, Bieber M, Vögtle T, Hofmann S, Klaus V, Kraft P, Seyhan M, Kollikowski AM, Papp L, Heuschmann PU, Pham M, Nieswandt B, Stegner D Tags: Circ Res Source Type: research

The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications.
Abstract The recent emergence of SARS-CoV-2 and the ensuing global pandemic has presented a health emergency of unprecedented magnitude. Recent clinical data has highlighted that COVID-19 is associated with a significant risk of thrombotic complications ranging from microvascular thrombosis, venous thromboembolic disease and stroke. Importantly, thrombotic complications are markers of severe COVID-19 and are associated with multi-organ failure and increased mortality. The evidence to date supports the concept that the thrombotic manifestations of severe COVID-19 is due to the ability of SARS-CoV-2 to invade endo¬...
Source: Circulation Research - June 25, 2020 Category: Cardiology Authors: McFadyen JD, Stevens H, Peter K Tags: Circ Res Source Type: research

Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability.
Conclusions: Our findings identify HDAC9 as a regulator of atherosclerotic plaque stability and IKK activation thus providing a mechanistic explanation for the prominence of HDAC9 as a vascular risk locus in genome-wide association studies. Its therapeutic inhibition may provide a potent lever to alleviate vascular inflammation. PMID: 32546048 [PubMed - as supplied by publisher]
Source: Circulation Research - June 16, 2020 Category: Cardiology Authors: Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RT, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, D Tags: Circ Res Source Type: research

Novel Methods for Quantification of Vasodepression and Cardioinhibition During Tilt-Induced Vasovagal Syncope.
Conclusions: The novel methods allowed the relative effects of SV, HR and TPR on BP to be assessed separately, even though all act together. The two major factors lowering BP in T-VVS were reduced SV and cardioinhibition. We suggest that the term 'vasodepression' in reflex syncope should not be limited to reduced arterial vasoconstriction, reflected in TPR, but should also encompass venous pooling, reflected in SV. PMID: 32460687 [PubMed - as supplied by publisher]
Source: Circulation Research - May 27, 2020 Category: Cardiology Authors: van Dijk JG, Ghariq M, Kerkhof FI, Reijntjes RH, van Houwelingen MJ, van Rossum IA, Saal DP, van Zwet EW, van Lieshout JJ, Thijs RD, Benditt DG Tags: Circ Res Source Type: research

Iron-Deficiency and Estrogen Are Associated with Ischemic Stroke by Up-Regulating Transferrin to Induce Hypercoagulability.
Conclusions: Our findings revealed that certain factors (i.e., ID and CC) up-regulating transferrin are risk factors of thromboembolic diseases decipher a previously unrecognized mechanistic association among ID, CC and IS and provide a novel strategy for the development of anti-IS medicine by interfering with transferrin-thrombin/FXIIa interactions. PMID: 32450779 [PubMed - as supplied by publisher]
Source: Circulation Research - May 25, 2020 Category: Cardiology Authors: Tang X, Fang M, Cheng R, Zhang Z, Wang Y, Shen C, Han Y, Lu Q, Du Y, Liu Y, Sun Z, Zhu L, Mwangi J, Xue M, Long C, Lai R Tags: Circ Res Source Type: research

Gut Microbiota-Derived Short-Chain Fatty Acids Promote Post-Stroke Recovery in Aged Mice.
Conclusions:This is the first study suggesting that the poor stroke recovery in aged mice can be reversed via "post-stroke bacteriotherapy" following the replenishment of youthful gut microbiome via modulation of immunologic, microbial and metabolomic profiles in the host. PMID: 32354259 [PubMed - as supplied by publisher]
Source: Circulation Research - April 30, 2020 Category: Cardiology Authors: Lee J, d'Aigle J, Atadja L, Quaicoe V, Honarpisheh P, Ganesh BP, Hassan A, Graf J, Petrosino JF, Putluri N, Zhu L, Durgan DJ, Bryan RM, McCullough LD, Venna VR Tags: Circ Res Source Type: research

Modifiable Cardiovascular Risk, Hematopoiesis, and Innate Immunity.
Abstract Unhealthy diet, lack of exercise, psychosocial stress, and insufficient sleep are increasingly prevalent modifiable risk factors for cardiovascular disease. Accumulating evidence indicates that these risk factors may fuel chronic inflammatory processes that are active in atherosclerosis and lead to myocardial infarction and stroke. In concert with hyperlipidemia, maladaptive immune system activities can contribute to disease progression and increase the probability of adverse events. In this review, we discuss recent insight into how the above modifiable risk factors influence innate immunity. Specificall...
Source: Circulation Research - April 23, 2020 Category: Cardiology Authors: Schloss MJ, Swirski FK, Nahrendorf M Tags: Circ Res Source Type: research

Sex as a Biological Variable in Atherosclerosis.
This article reviews the available data. Overall, male animals appear to have more inflamed yet smaller plaques compared to female animals. Plaque inflammation is often used as a surrogate end point for plaque vulnerability in animals. The available data support the notion that rather than plaque size, plaque inflammation may be more relevant in assessing sex-specific mechanisms since the findings correlate with the sex difference in ischemic events and mortality and thus may be more reflective of the human condition. Overall, the number of preclinical studies directly comparing plaque inflammation between the sexes is ext...
Source: Circulation Research - April 23, 2020 Category: Cardiology Authors: Man JJ, Beckman JA, Jaffe IZ Tags: Circ Res Source Type: research

Hematopoiesis and Cardiovascular Disease.
Abstract A central feature of atherosclerosis, the most prevalent chronic vascular disease and root cause of myocardial infarction and stroke, is leukocyte accumulation in the arterial wall. These crucial immune cells are produced in specialized niches in the bone marrow, where a complex cell network orchestrates their production and release. A growing body of clinical studies has documented a correlation between leukocyte numbers and cardiovascular disease risk. Understanding how leukocytes are produced and how they contribute to atherosclerosis and its complications is, therefore, critical to understanding and t...
Source: Circulation Research - April 9, 2020 Category: Cardiology Authors: Poller WC, Nahrendorf M, Swirski FK Tags: Circ Res Source Type: research

Targeting Myeloid-Specific Integrin α9β1 Improves Short and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis And Inflammation.
Conclusions: We provide genetic and pharmacologic evidence for the first time that targeting myeloid-specific integrin α9β1 improves short and long-term functional outcome in stroke models with preexisting comorbidities by limiting cerebral thrombosis and inflammation. PMID: 32195632 [PubMed - as supplied by publisher]
Source: Circulation Research - March 19, 2020 Category: Cardiology Authors: Dhanesha N, Jain M, Tripathi A, Doddapattar P, Chorawala M, Bathla G, Nayak MK, Ghatge M, Lentz SR, Kon S, Chauhan AK Tags: Circ Res Source Type: research

Endothelium-Targeted Deletion of microRNA-15a/16-1 Promotes Post-Stroke Angiogenesis and Improves Long-Term Neurological Recovery.
Conclusions: Endothelial miR-15a/16-1 cluster is a negative regulator for post-ischemic cerebral angiogenesis and long-term neurological recovery. Inhibition of miR-15a/16-1 function in cerebrovascular endothelium may be a legitimate therapeutic approach for stroke recovery. PMID: 32131693 [PubMed - as supplied by publisher]
Source: Circulation Research - March 4, 2020 Category: Cardiology Authors: Sun P, Zhang K, Hassan SH, Zhang X, Tang X, Pu H, Stetler RA, Chen J, Yin K Tags: Circ Res Source Type: research

Mildly Abnormal Lipid Levels, but Not High Lipid Variability, Are Associated with Increased Risk of Myocardial Infarction and Stroke in 'Statin-Naive' Young Population: A Nationwide Cohort Study.
Conclusions: Mildly abnormal baseline lipid levels were associated with an increased future risk of ASCVD events, particularly MI, whereas measures of lipid variability were not. Therefore, in young adults, achieving optimal lipid levels could be valuable in the prevention of ASCVD. PMID: 31978313 [PubMed - as supplied by publisher]
Source: Circulation Research - January 23, 2020 Category: Cardiology Authors: Park JB, Kim D, Lee H, Hwang IC, Yoon YE, Park HE, Choi SY, Kim YJ, Cho GY, Han KD, Kim HK Tags: Circ Res Source Type: research

Vitamin D, Marine n-3 Fatty Acids, and Primary Prevention of Cardiovascular Disease Current Evidence.
Abstract Whether marine omega-3 fatty acid (n-3 FA) or vitamin D supplementation can prevent cardiovascular disease (CVD) in general populations at usual risk for this outcome is unknown. A major goal of VITAL (Vitamin D and Omega-3 Trial) was to fill this knowledge gap. In this article, we review the results of VITAL, discuss relevant mechanistic studies regarding n-3 FAs, vitamin D, and vascular disease, and summarize recent meta-analyses of the randomized trial evidence on these agents. VITAL was a nationwide, randomized, placebo-controlled, 2×2 factorial trial of marine n-3 FAs (1 g/d) and vitamin D3 (2000 IU...
Source: Circulation Research - January 2, 2020 Category: Cardiology Authors: Manson JE, Bassuk SS, Cook NR, Lee IM, Mora S, Albert CM, Buring JE, VITAL Research Group Tags: Circ Res Source Type: research