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Source: Circulation Journal

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Total 475 results found since Jan 2013.

Efficacy and Safety of Adjusted-Dose Prasugrel Compared With Clopidogrel in Japanese Patients With Acute Coronary Syndrome.
Conclusions: Prasugrel 20/3.75mg was associated with a low incidence of ischemic events, similar to the results of TRITON-TIMI 38, and with a low risk of clinically serious bleeding in Japanese ACS patients. PMID: 24759796 [PubMed - as supplied by publisher]
Source: Circulation Journal - April 22, 2014 Category: Cardiology Authors: Saito S, Isshiki T, Kimura T, Ogawa H, Yokoi H, Nanto S, Takayama M, Kitagawa K, Nishikawa M, Miyazaki S, Nakamura M Tags: Circ J Source Type: research

Hyperuricemia and Transesophageal Echocardiographic Thromboembolic Risk in Patients With Atrial Fibrillation at Clinically Low-Intermediate Risk.
Conclusions: The serum UA level was associated with thromboembolic risk on TEE in patients with nonvalvular AF at low-intermediate risk stratified by clinical risk factors. PMID: 24805815 [PubMed - as supplied by publisher]
Source: Circulation Journal - May 8, 2014 Category: Cardiology Authors: Numa S, Hirai T, Nakagawa K, Ohara K, Fukuda N, Nozawa T, Inoue H Tags: Circ J Source Type: research

Positron Emission Tomography-Computed Tomography for Imaging of Inflammatory Cardiovascular Diseases.
Abstract Inflammation is a determinant of atherosclerotic plaque rupture, the event usually responsible for myocardial infarction and stroke. Possible causes of inflammatory cardiomyopathy include myocarditis, eosinophilic disease, and sarcoidosis. Although conventional imaging techniques can identify the site and severity of luminal stenosis, they do not provide information regarding inflammatory status. (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) for imaging of inflammatory cardiovascular diseases has been rapidly evolving. Integrated PET/computed tomography (CT) is becoming the method of c...
Source: Circulation Journal - May 9, 2014 Category: Cardiology Authors: Miyagawa M, Yokoyama R, Nishiyama Y, Ogimoto A, Higaki J, Mochizuki T Tags: Circ J Source Type: research

Alternation of Right Ventricular Contraction Pattern in Healthy Children.
Conclusions:Normal RV contraction pattern shifts from radial to longitudinal directions at approximately 15 mm of TAPSE. RVSV is primarily generated by longitudinal contraction, but in neonates, RVSV is supported not only by longitudinal contraction but also by radial contraction. PMID: 24848951 [PubMed - as supplied by publisher]
Source: Circulation Journal - May 22, 2014 Category: Cardiology Authors: Hashimoto I, Watanabe K Tags: Circ J Source Type: research

Clinical Research and the Development of Medical Therapeutics.
Abstract Clinical research plays a central role in the development of medical therapeutics, but the current system is estimated to take 10-15 years from initial discovery to regulatory approval, at a cost of approximately US$1 billion. Contrast the paths by which 2 anticoagulant options for atrial fibrillation were discovered and ultimately established as treatment options in clinical medicine. Warfarin was discovered by serendipity and compared with placebo in relatively small trials; this was associated with a low cost of development. The new oral anticoagulants were synthesized to provide highly specific, targe...
Source: Circulation Journal - May 16, 2014 Category: Cardiology Authors: Antman EM Tags: Circ J Source Type: research

Latest Advances in Transseptal Structural Heart Interventions.
Abstract Recent advances in structural heart intervention have produced increasing demand for transseptal access, which was first introduced as a diagnostic tool to directly measure left atrial pressure. Transseptal access allows safe and adequate approach to the left atrium and surrounding structures. Percutaneous transcatheter mitral valve repair using the MitraClip device is a safe and less invasive treatment for selected patients with significant mitral regurgitation, who are at high risk for surgery. This is an echocardiographic- and fluoroscopic-guided procedure requiring accurate transseptal access of the l...
Source: Circulation Journal - July 14, 2014 Category: Cardiology Authors: Matsumoto T, Kar S Tags: Circ J Source Type: research

Preoperative Tissue Doppler Imaging-Derived Atrial Conduction Time Can Predict Postoperative Atrial Fibrillation in Patients Undergoing Aortic Valve Replacement for Aortic Valve Stenosis.
Conclusions:The PA-TDI duration was an independent predictor of POAF after AVR for AS. Patients with PA-TDI duration >147 ms should be considered high risk and treated appropriately to improve outcomes. PMID: 25030299 [PubMed - as supplied by publisher]
Source: Circulation Journal - July 15, 2014 Category: Cardiology Authors: Takahashi S, Fujiwara M, Watadani K, Taguchi T, Katayama K, Takasaki T, Kurosaki T, Imai K, Sueda T Tags: Circ J Source Type: research

Thromboembolic Events in Paroxysmal vs. Permanent Non-Valvular Atrial Fibrillation.
Conclusions:The crude rate of thromboembolic events was higher in permanent NVAF than in paroxysmal NVAF, but after adjusting for warfarin use and CHA2DS2-VASc score components, paroxysmal and permanent NVAF patients had similar risk of thromboembolism. PMID: 25099606 [PubMed - as supplied by publisher]
Source: Circulation Journal - August 6, 2014 Category: Cardiology Authors: Inoue H, Atarashi H, Okumura K, Yamashita T, Kumagai N, Origasa H Tags: Circ J Source Type: research

Impact of Non-Vitamin K Antagonist Oral Anticoagulants on Intracranial Bleeding in Asian Patients With Non-Valvular Atrial Fibrillation.
Abstract The incidence of intracranial bleeding is known to be markedly higher in Japan and other East Asian countries than in countries outside of East Asia. Non-vitamin K antagonist oral anticoagulants (NOACs) have much lower risk of intracranial bleeding than warfarin, so we reviewed the effect of this class of drugs on intracranial bleeding in Asian patients with non-valvular atrial fibrillation (NVAF). Warfarin therapy in Asian or East Asian populations appears to be associated with lower efficacy, poorer safety and a much greater risk of intracranial bleeding when compared with non-Asian or non-East Asian gr...
Source: Circulation Journal - September 10, 2014 Category: Cardiology Authors: Yasaka M, Lip GY Tags: Circ J Source Type: research

Prognostic Value of Global Longitudinal Strain in Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis With Preserved Ejection Fraction.
Conclusions:Longitudinal function was severely impaired in patients with LFLPG AS and they had poor prognosis. GLS could stratify the high-risk group for future adverse outcomes. Patients with paradoxical LFLPG AS comprised a mixed group with different LV mechanical properties associated with different prognoses. PMID: 25273913 [PubMed - as supplied by publisher]
Source: Circulation Journal - September 30, 2014 Category: Cardiology Authors: Sato K, Seo Y, Ishizu T, Takeuchi M, Izumo M, Suzuki K, Yamashita E, Oshima S, Akashi YJ, Otsuji Y, Aonuma K Tags: Circ J Source Type: research

Bare-Metal vs. Drug-Eluting Stents in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention.
Conclusions:In real-world patients with AF undergoing PCI, DES use was associated with outcomes comparable to those with BMS without excess bleeding complications. More ST was seen in BMS-treated patients. PMID: 25298168 [PubMed - as supplied by publisher]
Source: Circulation Journal - October 9, 2014 Category: Cardiology Authors: Kiviniemi T, Puurunen M, Schlitt A, Rubboli A, Karjalainen P, Nammas W, Kirchhof P, Biancari F, Lip GY, Airaksinen KJ Tags: Circ J Source Type: research

Prasugrel, a Third-Generation P2Y12 Receptor Antagonist, in Patients With Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention.
Conclusions:These results support the risk-benefit profile of an adjusted dosing regimen of prasugrel in Japanese patients undergoing PCI. Larger studies are required to confirm these findings. PMID: 25342212 [PubMed - as supplied by publisher]
Source: Circulation Journal - October 21, 2014 Category: Cardiology Authors: Isshiki T, Kimura T, Ogawa H, Yokoi H, Nanto S, Takayama M, Kitagawa K, Nishikawa M, Miyazaki S, Ikeda Y, Nakamura M, Saito S Tags: Circ J Source Type: research

Prognostic Impact of Subclinical Microalbuminuria in Patients With Chronic Heart Failure.
Conclusions:Subclinical microalbuminuria was associated with increased risk of cardiovascular events in CHF patients with mildly reduced or preserved renal function. PMID: 25354552 [PubMed - as supplied by publisher]
Source: Circulation Journal - October 30, 2014 Category: Cardiology Authors: Miura M, Sakata Y, Miyata S, Nochioka K, Takada T, Tadaki S, Ushigome R, Yamauchi T, Takahashi J, Shimokawa H Tags: Circ J Source Type: research

Assessment of Lipophilic vs. Hydrophilic Statin Therapy in Acute Myocardial Infarction.
Conclusions:On 2-year comparison of hydrophilic and lipophilic statins there was no significant difference in prevention of secondary cardiovascular outcome. PMID: 25392071 [PubMed - as supplied by publisher]
Source: Circulation Journal - November 12, 2014 Category: Cardiology Authors: Izawa A, Kashima Y, Miura T, Ebisawa S, Kitabayashi H, Yamamoto H, Sakurai S, Kagoshima M, Tomita T, Miyashita Y, Koyama J, Ikeda U Tags: Circ J Source Type: research

Prognostic impact of subclinical microalbuminuria in patients with chronic heart failure.
CONCLUSIONS: Subclinical microalbuminuria was associated with increased risk of cardiovascular events in CHF patients with mildly reduced or preserved renal function. (Circ J 2014; 78: 2890-2898). PMID: 25421233 [PubMed - in process]
Source: Circulation Journal - November 25, 2014 Category: Cardiology Authors: Miura M, Sakata Y, Miyata S, Nochioka K, Takada T, Tadaki S, Ushigome R, Yamauchi T, Takahashi J, Shimokawa H Tags: Circ J Source Type: research