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Integration of ultra-high-pressure liquid chromatography-tandem mass spectrometry with machine learning for identifying fatty acid metabolite biomarkers of ischemic stroke.
We report for the first time the integration of ultra-high-pressure liquid chromatography-tandem mass spectrometry with machine learning for identifying fatty acid metabolite biomarkers of ischemic stroke. In particular, we develop an optimal model to discriminate ischemic stroke patients from healthy persons with 100% sensitivity and 93.18% specificity. This research may facilitate understanding the roles of fatty acid metabolites in stroke occurrence, holding great potential in clinical stroke diagnosis. PMID: 32409805 [PubMed - as supplied by publisher]
Source: Chemical Communications - May 14, 2020 Category: Chemistry Authors: Zhang L, Ma F, Qi A, Liu L, Zhang J, Xu S, Zhong Q, Chen Y, Zhang CY, Cai C Tags: Chem Commun (Camb) Source Type: research

A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells.
Abstract Heat stroke is a lethal condition which can cause dysfunction in the central nervous system, multi-organ damage and even death. However, there is still limited knowledge of the detailed mechanism about the roles of lysosomes in heat stroke due to lack of effective tools. Herein, we introduce our previously developed hemicyanine with a large D-π-A structure as the key fluorophore to develop a new fluorescent probe (CPY) for ratiometric mapping of lysosomal pH changes in live cells under a heat shock stimulus. PMID: 29670954 [PubMed - as supplied by publisher]
Source: Chemical Communications - April 19, 2018 Category: Chemistry Authors: Wu L, Wang Y, James TD, Jia N, Huang C Tags: Chem Commun (Camb) Source Type: research

Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe.
We report the first two-photon fluorescent probe of mammalian TrxR (TP-TRFS). TP-TRFS retains high specificity in recognizing TrxR. More importantly, the two-photon absorbing character of TP-TRFS enables it to be used in vivo. With the aid of TP-TRFS, a remarkable decline of the TrxR function was observed in the brain of a mouse model of stroke for the first time, providing a mechanistic link of TrxR dysfunction with stroke. PMID: 33107534 [PubMed - as supplied by publisher]
Source: Chemical Communications - October 27, 2020 Category: Chemistry Authors: Zhao J, Qu Y, Gao H, Zhong M, Li X, Zhang F, Chen Y, Gan L, Hu G, Zhang H, Zhang S, Fang J Tags: Chem Commun (Camb) Source Type: research

Organic nanoparticles with aggregation-induced emission for tracking bone marrow stromal cells in the rat ischemic stroke model.
Abstract Organic nanoparticles (NPs) with aggregation-induced emission (AIE) have been successfully used for tracking bone marrow stromal cells (BMSCs) in rats with ischemic stroke, highlighting the great potential of such fluorescent NPs in understanding the fate of transplanted stem cells for cell-based therapies. PMID: 25267167 [PubMed - as supplied by publisher]
Source: Chemical Communications - September 30, 2014 Category: Chemistry Authors: Li K, Yamamoto M, Chan SJ, Chiam MY, Qin W, Wong PT, Yim EK, Tang BZ, Liu B Tags: Chem Commun (Camb) Source Type: research

Design and photoisomerization dynamics of a new family of synthetic 2-stroke light driven molecular rotary motors.
Abstract A new family of light driven molecular rotary motors, which can be synthesized from easily available precursor compounds and which are capable of completing a full 360° revolution by two photoisomerization steps only, is proposed. The non-adiabatic molecular dynamic simulations show that the photoisomerization steps of the motor's working cycle occur on an ultrafast time scale (ca. 200-300 fs), have a very high quantum yield of isomerization (0.91-0.97), and display high selectivity of torsion in the same direction. It is expected that the new motor should remain operational at lower temperatures than th...
Source: Chemical Communications - April 15, 2019 Category: Chemistry Authors: Filatov M, Paolino M, Min SK, Choi CH Tags: Chem Commun (Camb) Source Type: research