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Source: International Review of Cell and Molecular Biology
Vaccination: Cancer Vaccines
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Total 195 results found since Jan 2013.
Armored modified vaccinia Ankara in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:87-142. doi: 10.1016/bs.ircmb.2023.05.003. Epub 2023 May 31.ABSTRACTCancer immunotherapy relies on unleashing the patient´s immune system against tumor cells. Cancer vaccines aim to stimulate both the innate and adaptive arms of immunity to achieve durable clinical responses. Some roadblocks for a successful cancer vaccine in the clinic include the tumor antigen of choice, the adjuvants employed to strengthen antitumor-specific immune responses, and the risks associated with enhancing immune-related adverse effects in patients. Modified vaccinia Ankara (MVA) belongs to the family of poxviru...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Cigdem Atay Jos é Medina-Echeverz Hubertus Hochrein Mark Suter Maria Hinterberger Source Type: research
Alphaviruses in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:143-168. doi: 10.1016/bs.ircmb.2023.03.011. Epub 2023 Jun 14.ABSTRACTAlphaviruses have frequently been engineered for cancer therapy, cancer immunotherapy, and cancer vaccine development. As members of self-replicating RNA viruses, alphaviruses provide high levels of transgene expression through efficient self-amplifying of their RNA genome in host cells. Alphavirus vectors can be used as recombinant viral particles or oncolytic viruses. Alternatively, either naked or nanoparticle-encapsulated RNA and DNA replicons can be utilized. In the context of cancer prevention and treatment, antitumor...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
Viral vectors engineered for gene therapy
Int Rev Cell Mol Biol. 2023;379:1-41. doi: 10.1016/bs.ircmb.2023.05.005. Epub 2023 Jul 1.ABSTRACTGene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rh...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
Applications of self-replicating RNA
Int Rev Cell Mol Biol. 2022;372:97-157. doi: 10.1016/bs.ircmb.2022.03.006. Epub 2022 Aug 17.ABSTRACTSelf-replicating RNA viral vectors have been engineered for both prophylactic and therapeutic applications. Mainly the areas of infectious diseases and cancer have been targeted. Both positive and negative strand RNA viruses have been utilized including alphaviruses, flaviviruses, measles viruses and rhabdoviruses. The high-level of RNA amplification has provided efficient expression of viral surface proteins and tumor antigens. Immunization studies in animal models have elicit robust neutralizing antibody responses. In the ...
Source: International Review of Cell and Molecular Biology - September 5, 2022 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
Advances in mRNA vaccines
Int Rev Cell Mol Biol. 2022;372:295-316. doi: 10.1016/bs.ircmb.2022.04.011. Epub 2022 Jun 21.ABSTRACTmRNA vaccines have been increasingly recognized as a powerful vaccine platform since the FDA approval of two COVID-19 mRNA vaccines, which demonstrated outstanding prevention efficacy as well as great safety profile. Notably, nucleoside modification and lipid nanoparticle-facilitated delivery has greatly improved the immunogenicity, stability, and translation efficiency of mRNA molecule. Here we review the recent progress in mRNA vaccine development, including nucleoside modification, in vitro synthesis and product purifica...
Source: International Review of Cell and Molecular Biology - September 5, 2022 Category: Cytology Authors: Mengyun Li Zining Wang Chunyuan Xie Xiaojun Xia Source Type: research
mRNA delivery technologies: Toward clinical translation
Int Rev Cell Mol Biol. 2022;372:207-293. doi: 10.1016/bs.ircmb.2022.04.010. Epub 2022 Jul 7.ABSTRACTMessenger RNA (mRNA)-therapies have recently taken a huge step toward clinic thanks to the first mRNA-based medicinal products marketed. mRNA features for clinical purposes are improved by chemical modifications, but the inclusion in a delivery system is a regular requirement. mRNA nanomedicines must be designed for the specific therapeutic purpose, protecting the nucleic acid and facilitating the overcoming of biological barriers. Polymers, polypeptides, and cationic lipids are the main used materials to design mRNA deliver...
Source: International Review of Cell and Molecular Biology - September 5, 2022 Category: Cytology Authors: Itziar G ómez-Aguado Julen Rodr íguez-Castejón Marina Beraza-Millor Alicia Rodr íguez-Gascón Ana Del Pozo-Rodr íguez Mar ía Ángeles Solinís Source Type: research
Applications of self-replicating RNA
Int Rev Cell Mol Biol. 2022;372:97-157. doi: 10.1016/bs.ircmb.2022.03.006. Epub 2022 Aug 17.ABSTRACTSelf-replicating RNA viral vectors have been engineered for both prophylactic and therapeutic applications. Mainly the areas of infectious diseases and cancer have been targeted. Both positive and negative strand RNA viruses have been utilized including alphaviruses, flaviviruses, measles viruses and rhabdoviruses. The high-level of RNA amplification has provided efficient expression of viral surface proteins and tumor antigens. Immunization studies in animal models have elicit robust neutralizing antibody responses. In the ...
Source: International Review of Cell and Molecular Biology - September 5, 2022 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
mRNA-based therapies: Preclinical and clinical applications
Int Rev Cell Mol Biol. 2022;372:1-54. doi: 10.1016/bs.ircmb.2022.04.007. Epub 2022 Jun 3.ABSTRACTAt the fundamental level, messenger RNA (mRNA)-based therapeutics involves the delivery of in vitro-transcribed (IVT) mRNA into the cytoplasm of a target cell, where it is translated into the desired protein. IVT mRNA presents various advantages compared to DNA and recombinant protein-based approaches that make it ideal for a broad range of therapeutic applications. IVT mRNA, which is translated in the cytoplasm after transfection into cells, can encode virtually any target protein. Notably, it does not enter the nucleus, which...
Source: International Review of Cell and Molecular Biology - September 5, 2022 Category: Cytology Authors: Musga Qureischi Julia Mohr Estibaliz Arellano-Viera Sarah Elspeth Knudsen Farrukh Vohidov Andoni Garitano-Trojaola Source Type: research
Advances in mRNA vaccines
Int Rev Cell Mol Biol. 2022;372:295-316. doi: 10.1016/bs.ircmb.2022.04.011. Epub 2022 Jun 21.ABSTRACTmRNA vaccines have been increasingly recognized as a powerful vaccine platform since the FDA approval of two COVID-19 mRNA vaccines, which demonstrated outstanding prevention efficacy as well as great safety profile. Notably, nucleoside modification and lipid nanoparticle-facilitated delivery has greatly improved the immunogenicity, stability, and translation efficiency of mRNA molecule. Here we review the recent progress in mRNA vaccine development, including nucleoside modification, in vitro synthesis and product purifica...
Source: International Review of Cell and Molecular Biology - September 5, 2022 Category: Cytology Authors: Mengyun Li Zining Wang Chunyuan Xie Xiaojun Xia Source Type: research
mRNA delivery technologies: Toward clinical translation
Int Rev Cell Mol Biol. 2022;372:207-293. doi: 10.1016/bs.ircmb.2022.04.010. Epub 2022 Jul 7.ABSTRACTMessenger RNA (mRNA)-therapies have recently taken a huge step toward clinic thanks to the first mRNA-based medicinal products marketed. mRNA features for clinical purposes are improved by chemical modifications, but the inclusion in a delivery system is a regular requirement. mRNA nanomedicines must be designed for the specific therapeutic purpose, protecting the nucleic acid and facilitating the overcoming of biological barriers. Polymers, polypeptides, and cationic lipids are the main used materials to design mRNA deliver...
Source: International Review of Cell and Molecular Biology - September 5, 2022 Category: Cytology Authors: Itziar G ómez-Aguado Julen Rodr íguez-Castejón Marina Beraza-Millor Alicia Rodr íguez-Gascón Ana Del Pozo-Rodr íguez Mar ía Ángeles Solinís Source Type: research
mRNA-based therapies: Preclinical and clinical applications
Int Rev Cell Mol Biol. 2022;372:1-54. doi: 10.1016/bs.ircmb.2022.04.007. Epub 2022 Jun 3.ABSTRACTAt the fundamental level, messenger RNA (mRNA)-based therapeutics involves the delivery of in vitro-transcribed (IVT) mRNA into the cytoplasm of a target cell, where it is translated into the desired protein. IVT mRNA presents various advantages compared to DNA and recombinant protein-based approaches that make it ideal for a broad range of therapeutic applications. IVT mRNA, which is translated in the cytoplasm after transfection into cells, can encode virtually any target protein. Notably, it does not enter the nucleus, which...
Source: International Review of Cell and Molecular Biology - September 5, 2022 Category: Cytology Authors: Musga Qureischi Julia Mohr Estibaliz Arellano-Viera Sarah Elspeth Knudsen Farrukh Vohidov Andoni Garitano-Trojaola Source Type: research
Applications of self-replicating RNA
Int Rev Cell Mol Biol. 2022;372:97-157. doi: 10.1016/bs.ircmb.2022.03.006. Epub 2022 Aug 17.ABSTRACTSelf-replicating RNA viral vectors have been engineered for both prophylactic and therapeutic applications. Mainly the areas of infectious diseases and cancer have been targeted. Both positive and negative strand RNA viruses have been utilized including alphaviruses, flaviviruses, measles viruses and rhabdoviruses. The high-level of RNA amplification has provided efficient expression of viral surface proteins and tumor antigens. Immunization studies in animal models have elicit robust neutralizing antibody responses. In the ...
Source: International Review of Cell and Molecular Biology - September 5, 2022 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
Advances in mRNA vaccines
Int Rev Cell Mol Biol. 2022;372:295-316. doi: 10.1016/bs.ircmb.2022.04.011. Epub 2022 Jun 21.ABSTRACTmRNA vaccines have been increasingly recognized as a powerful vaccine platform since the FDA approval of two COVID-19 mRNA vaccines, which demonstrated outstanding prevention efficacy as well as great safety profile. Notably, nucleoside modification and lipid nanoparticle-facilitated delivery has greatly improved the immunogenicity, stability, and translation efficiency of mRNA molecule. Here we review the recent progress in mRNA vaccine development, including nucleoside modification, in vitro synthesis and product purifica...
Source: International Review of Cell and Molecular Biology - September 5, 2022 Category: Cytology Authors: Mengyun Li Zining Wang Chunyuan Xie Xiaojun Xia Source Type: research
mRNA delivery technologies: Toward clinical translation
Int Rev Cell Mol Biol. 2022;372:207-293. doi: 10.1016/bs.ircmb.2022.04.010. Epub 2022 Jul 7.ABSTRACTMessenger RNA (mRNA)-therapies have recently taken a huge step toward clinic thanks to the first mRNA-based medicinal products marketed. mRNA features for clinical purposes are improved by chemical modifications, but the inclusion in a delivery system is a regular requirement. mRNA nanomedicines must be designed for the specific therapeutic purpose, protecting the nucleic acid and facilitating the overcoming of biological barriers. Polymers, polypeptides, and cationic lipids are the main used materials to design mRNA deliver...
Source: International Review of Cell and Molecular Biology - September 5, 2022 Category: Cytology Authors: Itziar G ómez-Aguado Julen Rodr íguez-Castejón Marina Beraza-Millor Alicia Rodr íguez-Gascón Ana Del Pozo-Rodr íguez Mar ía Ángeles Solinís Source Type: research
mRNA-based therapies: Preclinical and clinical applications
Int Rev Cell Mol Biol. 2022;372:1-54. doi: 10.1016/bs.ircmb.2022.04.007. Epub 2022 Jun 3.ABSTRACTAt the fundamental level, messenger RNA (mRNA)-based therapeutics involves the delivery of in vitro-transcribed (IVT) mRNA into the cytoplasm of a target cell, where it is translated into the desired protein. IVT mRNA presents various advantages compared to DNA and recombinant protein-based approaches that make it ideal for a broad range of therapeutic applications. IVT mRNA, which is translated in the cytoplasm after transfection into cells, can encode virtually any target protein. Notably, it does not enter the nucleus, which...
Source: International Review of Cell and Molecular Biology - September 5, 2022 Category: Cytology Authors: Musga Qureischi Julia Mohr Estibaliz Arellano-Viera Sarah Elspeth Knudsen Farrukh Vohidov Andoni Garitano-Trojaola Source Type: research
