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Source: Neurochemical Research
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Total 300 results found since Jan 2013.
Emerging Targets for Modulation of Immune Response and Inflammation in Stroke
Neurochem Res. 2023 Feb 10. doi: 10.1007/s11064-023-03875-2. Online ahead of print.ABSTRACTThe inflammatory and immunological responses play a significant role after stroke. The innate immune activation stimulated by microglia during stroke results in the migration of macrophages and lymphocytes into the brain and are responsible for tissue damage. The immune response and inflammation following stroke have no defined targets, and the intricacies of the immunological and inflammatory processes are only partially understood. Innate immune cells enter the brain and meninges during the acute phase, which can cause ischemia dam...
Source: Neurochemical Research - February 10, 2023 Category: Neuroscience Authors: Komal Thapa Kumar Shivam Heena Khan Amarjot Kaur Kamal Dua Sachin Singh Thakur Gurjeet Singh Source Type: research
Neuroprotective Roles of Apelin-13 in Neurological Diseases
This study summarizes the pathophysiological roles of apelin-13 in the development and progression of neurological related diseases.PMID:36745269 | DOI:10.1007/s11064-023-03869-0
Source: Neurochemical Research - February 6, 2023 Category: Neuroscience Authors: Yang Zhang Weiwei Jiang Wenjie Sun Weiming Guo Beibei Xia Xiangru Shen Mingyuan Fu Teng Wan Mei Yuan Source Type: research
Exosomal ZEB1 Derived from Neural Stem Cells Reduces Inflammation Injury in OGD/R-Treated Microglia via the GPR30-TLR4-NF- κB Axis
Neurochem Res. 2023 Jan 30. doi: 10.1007/s11064-023-03866-3. Online ahead of print.ABSTRACTIschemic stroke (IS) is the most common type of stroke and the second leading cause of death overall. Neural stem cells play protective roles in IS, but the underlying mechanism remains to be determined. Neural stem cells (NSC) were obtained from the fetal brain tissue of C57BL/6J mice. NSC-derived exosomes (NSC-Exos) were identified in the conditioned medium. Internalization of NSC-Exos was analyzed by fluorescence microscopy. In vitro microglia ischemic stroke injury model was induced using oxygen glucose deprivation/re-oxygenation...
Source: Neurochemical Research - January 30, 2023 Category: Neuroscience Authors: Jun Peng Zhengtao Yu Rongjun Xiao Xiqi Hu Ying Xia Source Type: research
Neuroprotective Effects of Conditioned Medium of Mesenchymal Stem Cells (MSC-CM) as a Therapy for Ischemic Stroke Recovery: A Systematic Review
Neurochem Res. 2022 Dec 30. doi: 10.1007/s11064-022-03848-x. Online ahead of print.ABSTRACTIt has been reported that the therapeutic potential of stem cells is mainly mediated by their paracrine factors. In order to identify the effects of conditioned medium of mesenchymal stem cells (MSC-CM) against stroke, a systematic review was conducted. We searched PubMed, Scopus, and ISI Web of Science databases for all available articles relevant to the effects of MSC-CM against the middle cerebral artery occlusion (MCAO) model of ischemic stroke until August 2022. The quality of the included studies was evaluated using The STAIR s...
Source: Neurochemical Research - December 29, 2022 Category: Neuroscience Authors: Mahin Behzadifard Nahid Aboutaleb Mojtaba Dolatshahi Maryam Khorramizadeh Hamzeh Mirshekari Jahangiri Zeynab Kord Donya Nazarinia Source Type: research
OIP5-AS1 Inhibits Oxidative Stress and Inflammation in Ischemic Stroke Through miR-155-5p/IRF2BP2 Axis
Neurochem Res. 2022 Dec 3. doi: 10.1007/s11064-022-03830-7. Online ahead of print.NO ABSTRACTPMID:36460840 | DOI:10.1007/s11064-022-03830-7
Source: Neurochemical Research - December 2, 2022 Category: Neuroscience Authors: Ji-Kun Zhang You Li Zheng-Tao Yu Jun-Wen Jiang Hong Tang Guo-Long Tu Ying Xia Source Type: research
Vitexin Improves Cerebral ischemia ‑reperfusion Injury by Attenuating Oxidative Injury and Ferroptosis via Keap1/Nrf2/HO-1signaling
In this study, we established the oxygen-glucose deprivation and reoxygenation (OGD/R) neuron cell and middle cerebral artery occlusion/reperfusion (MCAO/R) rat model. The cell viability, cell apoptosis and reactive oxygen species (ROS) levels were tested by CCK-8 assay and Flow cytometry, respectively. Hematoxylin-eosin staining, TTC, TEM, immunofluorescence analysis and western blot were used to investigate the effects of Vitexin. The results demonstrated that Vitexin could enhanced the cell viability and decreased the cell apoptosis in OGD/R cell model. Meanwhile, incubation with Vitexin maintained the neuroprotective e...
Source: Neurochemical Research - November 26, 2022 Category: Neuroscience Authors: Lei Guo Lei Shi Source Type: research
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury
Neurochem Res. 2022 Nov 19. doi: 10.1007/s11064-022-03822-7. Online ahead of print.ABSTRACTFerroptosis is characterized by excessive accumulation of iron and lipid peroxides, which are involved in ischemia, reperfusion-induced organ injury, and stroke. Propofol, an anesthetic agent, has neuroprotective effects due to its potent antioxidant, anti-ischemic, and anti-inflammatory properties. However, the relationship between propofol and ferroptosis is still unclear. In the current study, we elucidated the role of ferroptosis in the neuroprotective effect of propofol in mouse brains subjected to cerebral ischemia reperfusion ...
Source: Neurochemical Research - November 19, 2022 Category: Neuroscience Authors: Gui-Bo Fan Yan Li Gao-Shuo Xu A-Yang Zhao Hong-Jiang Jin Si-Qi Sun Si-Hua Qi Source Type: research
