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Source: Biomaterials
Therapy: Cancer Therapy
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Total 171 results found since Jan 2013.
Preparation of an Ultrahigh-DAR PDL1 monoclonal antibody-polymeric-SN38 conjugate for precise colon cancer therapy
Biomaterials. 2023 Aug 17;301:122285. doi: 10.1016/j.biomaterials.2023.122285. Online ahead of print.ABSTRACTAntibody-drug conjugates (ADCs) are the most potent active tumor-targeting agents used clinically. However, the preparation of ADCs with high drug-to-antibody ratios (DARs) remains a major challenge. Herein, a Fab-nondestructive SN38-loaded antibody-polymeric-drug conjugate (APDC), aPDL1-NPLG-SN38, was prepared that had a DAR as high as 72 for the first time, by increased numbers of payload binding sites via the carboxyl groups of poly (l-glutamic acid) (PLG). The bonding of Fc-III-4C peptide with PLG-graft-mPEG/SN3...
Source: Biomaterials - August 24, 2023 Category: Materials Science Authors: Honglei Zhang Jiali Sun Yu Zhang Zhenqian Zhang Xiaoshuang Wang Zhilin Liu Xuefei Zhang Zhaohui Tang Xuesi Chen Source Type: research
Controllable hypoxia-activated chemotherapy as a dual enhancer for synergistic cancer photodynamic immunotherapy
Biomaterials. 2023 Jul 26;301:122257. doi: 10.1016/j.biomaterials.2023.122257. Online ahead of print.ABSTRACTThe efficacy of photodynamic therapy (PDT) is severely limited by the hypoxic tumor microenvironment (TME), while the performance of PDT-aroused antitumor immunity is frustrated by the immunosuppressive TME and deficient immunogenic cell death (ICD) induction. To simultaneously tackle these pivotal problems, we herein create an albumin-based nanoplatform co-delivering IR780, NLG919 dimer and a hypoxia-activated prodrug tirapazamine (TPZ) as the dual enhancer for synergistic cancer therapy. Under NIR irradiation, IR7...
Source: Biomaterials - August 2, 2023 Category: Materials Science Authors: Mengyuan Wang Mengying He Mengyao Zhang Shujuan Xue Tao Xu Yanan Zhao Dazhao Li Feng Zhi Dawei Ding Source Type: research
Bioreducible exosomes encapsulating glycolysis inhibitors potentiate mitochondria-targeted sonodynamic cancer therapy via cancer-targeted drug release and cellular energy depletion
This study offers new insights into the use of dual stimuli-responsive exosomes encapsulating sonosensitizers for safe and targeted sonodynamic cancer therapy.PMID:37473534 | DOI:10.1016/j.biomaterials.2023.122242
Source: Biomaterials - July 20, 2023 Category: Materials Science Authors: Thuy Giang Nguyen Cao Quan Truong Hoang Ji Hee Kang Su Jin Kang Vasanthan Ravichandran Won Jong Rhee Minjong Lee Young Tag Ko Min Suk Shim Source Type: research
Tumor microenvironment-initiated lipid redox cycling for efficient triple-negative breast cancer therapy
Biomaterials. 2023 Jun 17;300:122205. doi: 10.1016/j.biomaterials.2023.122205. Online ahead of print.ABSTRACTThe use of overwhelming reactive oxygen species (ROS) attack has shown great potential for treating aggressive malignancies; however, targeting this process for further applications is greatly hindered by inefficiency and low selectivity. Here, a novel strategy for ROS explosion induced by tumor microenvironment-initiated lipid redox cycling was proposed, which was developed by using soybean phosphatidylcholine (SPC) to encapsulate lactate oxidase (LOX) and sorafenib (SRF) self-assembled nanoparticles (NPs), named L...
Source: Biomaterials - June 22, 2023 Category: Materials Science Authors: Tian-Jiao Zhou Xing Wan Meng-Meng Zhang Dan-Meng Liu Li-Ling Huang Lei Xing Yi Wang Hu-Lin Jiang Source Type: research
Blue light promotes vitamin C-mediated ferroptosis of melanoma through specifically upregulating transporter SVCT2 and generating Fe < sup > 2 < /sup >
Biomaterials. 2023 May 31;299:122186. doi: 10.1016/j.biomaterials.2023.122186. Online ahead of print.ABSTRACTVitamin C (VC)-based cancer therapy is a promising therapeutic approach for a variety of cancers due to its profound effects on redox reactions and metabolic pathways. However, high administration dosage of VC for necessary therapeutic efficacy for cancers increases the risk of overt side effects and limits its clinical use. Here, we show cutaneous blue light irradiation can specifically upregulate the sodium-dependent vitamin C transporter 2 (SVCT2) of the tumor and increase effectively the VC concentration at the ...
Source: Biomaterials - June 5, 2023 Category: Materials Science Authors: Rong Yang Fangqing Deng Yingchun Yang Qing Tian Shuaiqi Huangfu Luqiu Yang Jing Hou Guanghao Yang Wei Pang Jueru Lu Hui Liu Yao Chen Jie Gao Lianbing Zhang Source Type: research
Atomic vacancies-engineered ultrathin trimetallic nanozyme with anti-inflammation and antitumor performances for intestinal disease treatment
Biomaterials. 2023 May 27;299:122178. doi: 10.1016/j.biomaterials.2023.122178. Online ahead of print.ABSTRACTColitis-associated colorectal cancer, which represents a highly aggressive subtypes of colorectal cancer, requires concurrent antitumor and anti-inflammation therapies in clinic. Herein, we successfully engineered Ru38Pd34Ni28 ultrathin trimetallic nanosheets (TMNSs) by introducing diverse transition metal atoms into the structure of RuPd nanosheets. Density functional theory (DFT) calculations reveal that the elaborate introduction of transition metal Ru and Ni facilitates the formation of Ru-O and Ni-O bonds on th...
Source: Biomaterials - June 4, 2023 Category: Materials Science Authors: Yachao Wang Xinyue Dai Lina Wu Huijing Xiang Yu Chen Ruifang Zhang Source Type: research
Evaluation of a DoE based approach for comprehensive modelling of the effect of lipid nanoparticle composition on nucleic acid delivery
Biomaterials. 2023 May 15;299:122158. doi: 10.1016/j.biomaterials.2023.122158. Online ahead of print.ABSTRACTTherapeutic nucleic acids (TNAs) comprise an alternative to conventional drugs for cancer therapy. Recently, stable nucleic acid lipid particles (SNALPs) have been explored to deliver TNA efficiently and safely both in vitro and in vivo. Small interfering RNA (siRNA) and messenger RNA (mRNA) based drugs have been suggested for a wide range of pathologies, and their respective lipid nanoparticle (LNP) formulations have been optimised using a Design of Experiments (DoE) approach. However, it is uncertain as to whether...
Source: Biomaterials - May 27, 2023 Category: Materials Science Authors: Yue Qin Adam A Walters Nadia Rouatbi Julie Tzu-Wen Wang Hend Mohamed Abdel-Bar Khuloud T Al-Jamal Source Type: research
