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Source: American Journal of Physiology. Heart and Circulatory Physiology
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Total 253 results found since Jan 2013.
Carvedilol and Exercise Combination Therapy Improves Systolic but not Diastolic Function and Reduces Plasma Osteopontin in Col4a3-/- Mice
Am J Physiol Heart Circ Physiol. 2021 Mar 26. doi: 10.1152/ajpheart.00535.2020. Online ahead of print.ABSTRACTThere are currently no FDA-approved treatments for heart failure with preserved ejection fraction (HFpEF). Here we compared the effects of exercise with and without α/β-adrenergic blockade with carvedilol in Col4a3-/- Alport mice, a model of the Phenogroup 3 subclass of HFpEF with underlying renal dysfunction. Alport mice were assigned to the following groups: no treatment control (n=29), carvedilol (n=11), voluntary exercise (n=9), combination carvedilol and exercise (n=8). Cardiac function was assessed by echoc...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 26, 2021 Category: Physiology Authors: Julian C Dunkley Camila I Irion Keyvan Yousefi Serene A Shehadeh Guerline Lambert Krista John-Williams Keith A Webster Jeffrey J Goldberger Lina A Shehadeh Source Type: research
Soluble guanylate cyclase stimulation in late gestation does not mitigate asymmetric IUGR or cardiovascular risk induced by placental ischemia in the rat
This study tested the hypothesis that stimulation of sGC until birth attenuates asymmetric IUGR mitigating increased cardiovascular risk in offspring. Sham or RUPP surgery was performed at gestational day 14 (G14); vehicle or sGC stimulator, Riociguat (10mg/kg/day, s.c.) were administered G14 until birth. Birth weight was reduced in offspring from RUPP (intrauterine growth restricted or IUGR), sGC RUPP (sGC IUGR), and sGC Sham (sGC Control) compared to Sham (Control). Crown circumference was maintained but abdominal circumference was reduced in IUGR and sGC IUGR compared to Control indicative of asymmetrical growth. Gestat...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 19, 2021 Category: Physiology Authors: Laura E Coats Bhavisha A Bakrania Daniel R Bamrick-Fernandez Allison M Ariatti Adam Z Rawls Norma B Ojeda Barbara T Alexander Source Type: research
Exercise alters Cardiac Function Independent of Acute Systemic Inflammation in Healthy Men
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00809.2020. Online ahead of print.ABSTRACTAcute elevations in inflammatory cytokines have been demonstrated to increase aortic and left ventricular stiffness and reduce endothelial function in healthy subjects. As vascular and cardiac function are often transiently reduced following prolonged exercise, it is possible that cytokines released during exercise may contribute to these alterations. The a priori aims of this study were to determine if vaccine-induced increases in inflammatory-cytokines would reduce vascular and left ventricular function, whether ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Alexandra M Coates Heather L Petrick Philip J Millar Jamie F Burr Source Type: research
Cardiac myosin binding protein-C phosphorylation accelerates β-cardiac myosin detachment rate in mouse myocardium
Am J Physiol Heart Circ Physiol. 2021 Mar 5. doi: 10.1152/ajpheart.00673.2020. Online ahead of print.ABSTRACTCardiac myosin binding protein-C (cMyBP-C) is a thick filament protein that modulates cardiac contraction-relaxation through its phosphorylation. Phosphorylation of cMyBP-C and ablation of cMyBP-C have been shown to increase the rate of MgADP release in the acto-myosin crossbridge cycle in the intact sarcomere. The influence of cMyBP-C on Pi-dependent myosin kinetics has not yet been examined. We investigated the effect of cMyBP-C and its phosphorylation on myosin kinetics in demembranated papillary muscle strips be...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 5, 2021 Category: Physiology Authors: Bertrand C W Tanner Michael J Previs Yuan Wang Jeffrey Robbins Bradley M Palmer Source Type: research
