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Source: American Journal of Physiology. Heart and Circulatory Physiology
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Total 253 results found since Jan 2013.
Metalloproteinases and Their Inhibitors Are Associated with Pulmonary Arterial Stiffness and Ventricular Function in Pediatric Pulmonary Hypertension
Am J Physiol Heart Circ Physiol. 2021 Jun 4. doi: 10.1152/ajpheart.00750.2020. Online ahead of print.ABSTRACTDisturbed balance between matrix metalloproteinases (MMPs) and their respective tissue inhibitors (TIMPs) is a well-recognized pathophysiologic component of pulmonary arterial hypertension (PAH). Both classes of proteases have been associated with clinical outcomes as well as with specific pathologic features of ventricular dysfunction and pulmonary arterial remodeling. The purpose of this study was to evaluate the circulating levels of MMPs and TIMPs in children with PAH undergoing the same day cardiac MRI and righ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - June 4, 2021 Category: Physiology Authors: Michal Schafer D Dunbar Ivy Kathleen Nguyen Katie L Boncella Benjamin S Frank Gareth J Morgan Kathleen Miller-Reed Uyen Truong Kelley L Colvin Michael E Yeager Source Type: research
Deficiency of Ataxia-Telangiectasia Mutated Kinase Modulates Functional and Biochemical Parameters of the Heart in Response to Western-type Diet
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00990.2020. Online ahead of print.ABSTRACTAtaxia telangiectasia mutated kinase (ATM) deficiency exacerbates heart dysfunction late after myocardial infarction. Here, we hypothesized that ATM deficiency modulates Western-type diet (WD)-induced cardiac remodeling with an emphasis on functional and biochemical parameters of the heart. Weight gain was assessed in male wild-type (WT) and ATM heterozygous knockout (hKO) mice on weekly basis, while cardiac functional and biochemical parameters were measured 14 weeks post-WD. hKO-WD mice exhibited rapid body weigh...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Mary C Wingard Suman Dalal Paige L Shook Rachel Myers Barbara A Connelly Douglas P Thewke Mahipal Singh Krishna Singh Source Type: research
Sildenafil Administration Improves Right Ventricular Function on 4D Flow MRI in Young Adults Born Premature
CONCLUSIONS: Despite reduced right atrial workload, metoprolol significantly depressed overall cardiac systolic function. Sildenafil, however, increased CI and improved RV function, as quantified by the direct flow fraction. The preterm heart appears dependent on HR, but sensitive to RV afterload manipulations.PMID:33861148 | DOI:10.1152/ajpheart.00824.2020
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Philip A Corrado Gregory P Barton Christopher J Fran çois Oliver Wieben Kara N Goss Source Type: research
Carvedilol and Exercise Combination Therapy Improves Systolic but not Diastolic Function and Reduces Plasma Osteopontin in Col4a3-/- Mice
Am J Physiol Heart Circ Physiol. 2021 Mar 26. doi: 10.1152/ajpheart.00535.2020. Online ahead of print.ABSTRACTThere are currently no FDA-approved treatments for heart failure with preserved ejection fraction (HFpEF). Here we compared the effects of exercise with and without α/β-adrenergic blockade with carvedilol in Col4a3-/- Alport mice, a model of the Phenogroup 3 subclass of HFpEF with underlying renal dysfunction. Alport mice were assigned to the following groups: no treatment control (n=29), carvedilol (n=11), voluntary exercise (n=9), combination carvedilol and exercise (n=8). Cardiac function was assessed by echoc...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 26, 2021 Category: Physiology Authors: Julian C Dunkley Camila I Irion Keyvan Yousefi Serene A Shehadeh Guerline Lambert Krista John-Williams Keith A Webster Jeffrey J Goldberger Lina A Shehadeh Source Type: research
