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Source: American Journal of Physiology. Heart and Circulatory Physiology
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Total 253 results found since Jan 2013.
Deferoxamine Prevents Post-Stroke Memory Impairment in Female Diabetic Rats: Potential Links to Hemorrhagic Transformation and Ferroptosis
Am J Physiol Heart Circ Physiol. 2022 Dec 23. doi: 10.1152/ajpheart.00490.2022. Online ahead of print.ABSTRACTDiabetes increases the risk of post-stroke cognitive impairment (PSCI). Greater hemorrhagic transformation (HT) after stroke is associated with vasoregression and cognitive decline in male diabetic rats. Iron chelator deferoxamine (DFX) prevents vasoregression and improves outcomes. While diabetic female rats develop greater HT, its impact on post-stroke cerebrovascularization and cognitive outcomes remained unknown. We hypothesized that diabetes mediates pathological neovascularization, and DFX attenuates post-str...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 23, 2022 Category: Physiology Authors: Weiguo Li Yasir Abdul Raghavendar Chandran Sarah Jamil Rebecca A Ward Mohammed Abdelsaid Guangkuo Dong Susan C Fagan Adviye Ergul Source Type: research
Detrimental effects of transient cerebral ischemia on middle cerebral artery mitochondria in female rats
Am J Physiol Heart Circ Physiol. 2022 Nov 11. doi: 10.1152/ajpheart.00346.2022. Online ahead of print.ABSTRACTMitochondrial numbers and dynamics in brain blood vessels differ between young male and female rats under physiological conditions, but how these differences are affected by stroke is unclear. In males, we found that mitochondrial numbers, possibly due to mitochondrial fission, in large middle cerebral arteries (MCAs) increased following transient middle cerebral artery occlusion (tMCAO). However, mitochondrial effects of stroke on MCAs of female rats have not been studied. To address this disparity, we conducted m...
Source: American Journal of Physiology. Heart and Circulatory Physiology - November 11, 2022 Category: Physiology Authors: Ibolya Rutkai Ivan Merdzo Sanjay Wunnava Catherine McNulty Partha K Chandra Prasad V Katakam David W Busija Source Type: research
Aortic distensibility is equal in prepubertal girls and boys and increases with puberty in girls
In conclusion, prepubertal girls and boys have equal conductance artery function. Thus, the well-known sex difference in adult conductance artery function seems to develop after the onset of puberty with girls initially increasing aortic distensibility.PMID:35687504 | DOI:10.1152/ajpheart.00097.2022
Source: American Journal of Physiology. Heart and Circulatory Physiology - June 10, 2022 Category: Physiology Authors: Ikram Mizrak Louise L Asserh øj Morten A V Lund Gorm O Greisen Tine D Clausen Katharina M Main Niels G Vejlstrup Rikke B Jensen Anja Pinborg Per L Madsen Source Type: research
Physical and Physiologic Effects of Dobutamine Stress Echocardiography in Low-Gradient Aortic Stenosis
CONCLUSION: During DSE, aortic valve area increases with increase aortic valve gradient. Higher calcium score is associated with lower baseline aortic valve area, but the area valve area still increases with dobutamine even in presence of high calcium score.PMID:34860593 | DOI:10.1152/ajpheart.00183.2021
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 3, 2021 Category: Physiology Authors: Kimi Sato Tom Kai Ming Wang Milind Y Desai Samir R Kapadia Amar Krishnaswamy L Leonardo Rodriguez Richard A Grimm Brian P Griffin Zoran B Popovic Source Type: research
