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Source: American Journal of Physiology. Heart and Circulatory Physiology

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Total 253 results found since Jan 2013.

Post Stroke Cognitive Impairment and Hippocampal Neurovascular Remodeling: The Impact of Diabetes and Sex.
Abstract Diabetes increases the risk and severity of cognitive impairment, especially after ischemic stroke. Pathological remodeling of the cerebrovasculature has been postulated to contribute to poor neuronal repair and worsened cognitive deficits in diabetes. However, little is known about the effect of diabetes on the vascularization of hippocampus, a domain critical to memory and learning. Therefore we had two aims for this study: 1) to determine the impact of diabetes on hippocampal neurovascular remodeling and the resulting cognitive impairment after stroke using two models with varying disease severity, and...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 17, 2018 Category: Physiology Authors: Ward R, Valenzuela JP, Li W, Dong G, Fagan SC, Ergul A Tags: Am J Physiol Heart Circ Physiol Source Type: research

Deferoxamine Prevents Post-Stroke Memory Impairment in Female Diabetic Rats: Potential Links to Hemorrhagic Transformation and Ferroptosis
Am J Physiol Heart Circ Physiol. 2022 Dec 23. doi: 10.1152/ajpheart.00490.2022. Online ahead of print.ABSTRACTDiabetes increases the risk of post-stroke cognitive impairment (PSCI). Greater hemorrhagic transformation (HT) after stroke is associated with vasoregression and cognitive decline in male diabetic rats. Iron chelator deferoxamine (DFX) prevents vasoregression and improves outcomes. While diabetic female rats develop greater HT, its impact on post-stroke cerebrovascularization and cognitive outcomes remained unknown. We hypothesized that diabetes mediates pathological neovascularization, and DFX attenuates post-str...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 23, 2022 Category: Physiology Authors: Weiguo Li Yasir Abdul Raghavendar Chandran Sarah Jamil Rebecca A Ward Mohammed Abdelsaid Guangkuo Dong Susan C Fagan Adviye Ergul Source Type: research

SOD1 Overexpression Prevents Acute Hyperglycemia-Induced Cerebral Myogenic Dysfunction: Relevance to Contralateral Hemisphere and Stroke Outcomes.
Conclusion: Our results showed that SOD1 overexpression nullified the detrimental effects of HG on myogenic tone and stroke outcomes, and that contralateral hemisphere may be a novel target for the management of acute hyperglycemic stroke. PMID: 25552308 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 31, 2014 Category: Physiology Authors: Coucha M, Li W, Hafez S, Abdelsaid M, Johnson MH, Fagan SC, Ergul A Tags: Am J Physiol Heart Circ Physiol Source Type: research

Kruppel-like Factor 2 Protects Against Ischemic Stroke by Regulating Endothelial Blood Brain Barrier Function.
In this study we sought to determine the role of KLF2 in cerebrovascular function and the pathogenesis of ischemic stroke. Transient middle cerebral artery occlusion (tMCAO) was performed in KLF2 deficient (KLF2(-/-)), KLF2 overexpressing (KLF2(tg)), and control mice and stroke volume analyzed. BBB function was assessed in vivo by real time neuroimaging using positron emission tomography (PET) and Evan's blue dye (EBD) assay. KLF2(-/-) mice exhibited significantly larger strokes and impairment in BBB function. In contrast, KLF2(tg) mice were protected against ischemic stroke and demonstrated preserved BBB function. In conc...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 18, 2013 Category: Physiology Authors: Shi H, Sheng B, Zhang F, Wu C, Zhang R, Zhu J, Xu K, Kuang Y, Jameson SC, Lin Z, Wang Y, Chen J, Jain MK, Atkins GB Tags: Am J Physiol Heart Circ Physiol Source Type: research

Angiotensin Type 2 Receptor Stimulation With Compound 21 Improves Neurological Function after Stroke In Female Rats: A Pilot Study.
In conclusion, C21 improves stroke outcome in female rats probably through increased expression of PPARĪ³. The ability of C21 to exert its neuroprotective effects might be affected by fluctuating levels of female hormones. PMID: 30822121 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 28, 2019 Category: Physiology Authors: Eldahshan W, Ishrat T, Pillai B, Sayed M, Alwhaibi A, Fouda AY, Ergul A, Fagan SC Tags: Am J Physiol Heart Circ Physiol Source Type: research