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Source: Acta Virologica
Vaccination: Influenza Vaccine

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Total 131 results found since Jan 2013.

DNA vaccine targeting the ectodomain of influenza M2 protein to endolysosome pathway enhances anti-M2e protective antibody response in mice
Acta Virol. 2021;65(2):181-191. doi: 10.4149/av_2021_207.ABSTRACTA promising candidate for developing the universal influenza vaccine is the ectodomain of the M2 protein (M2e). We designed and prepared an experimental DNA vaccine with an improved potential to induce anti-M2e immune response. The sequence for truncated NS1 protein followed by 4xM2e was inserted into the expression vector pTriEx-4 (pEx). M2e repeats were fused to the transmembrane domain and cytoplasmic tail of lysosome-associated membrane glycoprotein 2 isoform A (LAMP-2a) to target the M2e to the endo-lysosome pathway, facilitating increased antigen presen...
Source: Acta Virologica - June 16, 2021 Category: Infectious Diseases Authors: Jaroslav Holl ý Karol ína Tomčíková M ária Vozárová Margar éta Fogelová Lucia Jakubcov á Eva Vare čková Franti šek Kostolanský Source Type: research