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Source: Acta Neurobiologiae Experimentalis

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Total 638 results found since Jan 2013.

Bone marrow stromal cell transplantation for ischemic stroke - its multi-functional feature.
Abstract In this article, the author reviews recent advancements of basic research on bone marrow stromal cell (BMSC) transplantation for ischemic stroke. The BMSCs are easily isolated from the patients themselves and transplanted into them without any ethical and immunological problem. Animal experiments have shown that BMSC transplantation significantly enhance the recovery of motor and/or cognitive function in various types of neurological disorders such as ischemic stroke. The transplanted BMSCs aggressively migrate toward the damaged tissue and proliferate in the host brain. The BMSCs significantly improve th...
Source: Acta Neurobiologiae Experimentalis - May 25, 2013 Category: Neurology Authors: Kuroda S Tags: Acta Neurobiol Exp (Wars) Source Type: research

Bone marrow stromal cell transplantation enhances recovery of motor function after lacunar stroke in rats.
This study was aimed to clarify if the bone marrow stromal cells (BMSCs) significantly improve functional outcome after lacunar stroke when stereotactically transplanted into the brain. Ouabain, a Na/K ATPase pump inhibitor, was stereotactically injected into the right striatum of Wistar rats. One week later, the superparamagnetic iron oxide (SPIO)-labeled rat BMSCs (n=7) or vehicle (n=8) were stereotactically transplanted into the left striatum. Using rotarod test, motor function was serially evaluated through the experiment. A 7.0-T MR apparatus was employed to serially monitor the migration of BMSCs in the host brain. H...
Source: Acta Neurobiologiae Experimentalis - October 19, 2013 Category: Neurology Authors: Shichinohe H, Yamauchi T, Saito H, Houkin K, Kuroda S Tags: Acta Neurobiol Exp (Wars) Source Type: research

Human albumin aggravates cerebral edema by disrupting the blood ‑brain barrier in a rat model of ischemic stroke
Acta Neurobiol Exp (Wars). 2022;82(3):284-294. doi: 10.55782/ane-2022-027.ABSTRACTCerebral edema and elevated intracranial pressure (ICP) are common complications observed following ischemic stroke. Osmotherapy has been used as a foundation to manage ICP induced by cerebral edema, and albumin is one of the most commonly used osmotic agents. The present study aimed to explore whether albumin lowered ICP by reducing cerebral edema when albumin elevated the colloid osmotic pressure (COP) of plasma. Sprague‑Dawley rats that underwent middle cerebral artery occlusion were used to assess COP and ICP. Magnetic resonance imaging...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Chunchang Li Shiying Zhang Xin Jiang Zhuo Li Yiqin Zhang Xusheng Li Hongguang Ding Hongke Zeng Source Type: research