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Source: Acta Neurobiologiae Experimentalis
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LACC1 contributes to inflammation and cognitive disorder after stroke via the AMPK/NLRP3 pathway
Acta Neurobiol Exp (Wars). 2022;82(2):207-212. doi: 10.55782/ane-2022-019.ABSTRACTThe current study aimed to investigate the effects of LACC1 on cognitive disorder due to stroke, as well as its underlying mechanism. LACC1 promoted inflammation and aggravated cognitive impairment in a mouse model of stroke. In an in vitro model of stroke, inhibition of LACC1 reduced inflammation and ROS‑induced oxidative stress by activating AMP‑activated protein kinase (AMPK) expression and suppressing NLPR3 expression. Furthermore, our studies revealed that inhibition of AMPK activity reduced the effects of si‑LACC1 on cognitive dis...
Source: Acta Neurobiologiae Experimentalis - July 14, 2022 Category: Neurology Authors: Junping Jiao Shujuan Tian Junqiang Bao Zhiwei Wang Xiongwei Xie Guofeng Yang Source Type: research
