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Source: Acta Neurobiologiae Experimentalis

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Total 638 results found since Jan 2013.

LncRNA NEAT1 alleviates ischemic stroke via transcriptional inhibition of NLRP3 mediated by the miR ‑10b‑5p/BCL6 axis
Acta Neurobiol Exp (Wars). 2022;82(1):12-21. doi: 10.55782/ane-2022-002.ABSTRACTCerebral ischemic stroke (CIS) is a significant cause of disability and death. Inflammation usually occurs after CIS and accelerates cellular damage. NLRP3 plays a key role in the formation of CIS‑associated inflammasome. Understanding how NLRP3 is regulated bears great importance. We hypothesized that lncRNA NEAT1 can downregulate NLRP3 expression by regulating the miR‑10b‑5p/BCL6 axis, and thus regulate microglia‑driven inflammation. The expression of NEAT1 was analyzed in CIS patients and an in vitro model of oxygen and glucose depri...
Source: Acta Neurobiologiae Experimentalis - April 22, 2022 Category: Neurology Authors: Zhi-Wen Zhou Xiang Ren Wen-Sheng Zhou Ai-Ping Li Li-Jun Zheng Source Type: research

Homonymous hemianopia and related visual defects: Restoration of vision after a stroke.
Abstract The term homonymous hemianopia refers to visual impairment due to a post-chiasmatic brain lesion. Mammalian neurons of the central nervous system do not have the ability to regenerate. However, the cerebral cortex shows plasticity in certain cases. Motor or speech disorders due to frontal lobe brain damage can be improved with well-directed rehabilitation techniques. If such plasticity is possible, it raises the question whether specialized training could improve a cortical visual disorder. There is need for simple visual training which could be used in rehabilitation. A few different approaches have been...
Source: Acta Neurobiologiae Experimentalis - July 6, 2013 Category: Neurology Authors: Grunda T, Marsalek P, Sykorova P Tags: Acta Neurobiol Exp (Wars) Source Type: research

Optical coherence tomography reveals heterogeneity of the brain tissue and vasculature in the ischemic region after photothrombotic stroke in mice
Acta Neurobiol Exp (Wars). 2022;82(1):106-119. doi: 10.55782/ane‑2022‑010.ABSTRACTWe demonstrate in vivo imaging of the ischemic area in the mouse brain after photostroke using a custom prototype Gaussian‑beam optical coherence tomography (OCT) setup in which the near infrared imaging beam and the green photoinducing light pass through the same objective lens. The goal of our research was analysis of vascularity of the ischemic area during 2‑week progress of stroke and correlating the hypo‑ and hyperreflective OCT scattering areas with the location of activated microglia and astroglia. Angiogenesis, which was ass...
Source: Acta Neurobiologiae Experimentalis - April 22, 2022 Category: Neurology Authors: Hubert Dole życzek Piotr Kasprzycki Jakub W łodarczyk Maciej Wojtkowski Monika Malinowska Source Type: research