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Source: Acta Neurobiologiae Experimentalis
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LncRNA NEAT1 alleviates ischemic stroke via transcriptional inhibition of NLRP3 mediated by the miR ‑10b‑5p/BCL6 axis
Acta Neurobiol Exp (Wars). 2022;82(1):12-21. doi: 10.55782/ane-2022-002.ABSTRACTCerebral ischemic stroke (CIS) is a significant cause of disability and death. Inflammation usually occurs after CIS and accelerates cellular damage. NLRP3 plays a key role in the formation of CIS‑associated inflammasome. Understanding how NLRP3 is regulated bears great importance. We hypothesized that lncRNA NEAT1 can downregulate NLRP3 expression by regulating the miR‑10b‑5p/BCL6 axis, and thus regulate microglia‑driven inflammation. The expression of NEAT1 was analyzed in CIS patients and an in vitro model of oxygen and glucose depri...
Source: Acta Neurobiologiae Experimentalis - April 22, 2022 Category: Neurology Authors: Zhi-Wen Zhou Xiang Ren Wen-Sheng Zhou Ai-Ping Li Li-Jun Zheng Source Type: research
