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State-of-the-Art Techniques to Causally Link Neural Plasticity to Functional Recovery in Experimental Stroke Research.
Abstract Current experimental stroke research faces the same challenge as neuroscience: to transform correlative findings in causative ones. Research of recent years has shown the tremendous potential of the central nervous system to react to noxious stimuli such as a stroke: Increased plastic changes leading to reorganization in form of neuronal rewiring, neurogenesis, and synaptogenesis, accompanied by transcriptional and translational turnover in the affected cells, have been described both clinically and in experimental stroke research. However, only minor attempts have been made to connect distinct plastic re...
Source: Neural Plasticity - July 7, 2018 Category: Neurology Authors: Wahl AS Tags: Neural Plast Source Type: research

Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities.
Abstract With the rise in the aging global population, stroke comorbidities have become a serious health threat and a tremendous economic burden on human society. Current therapeutic strategies mainly focus on protecting neurons from cytotoxic damage at the acute phase upon stroke onset, which not only is a difficult way to ameliorate stroke symptoms but also presents a challenge for the patients to receive effective treatment in time. The brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the adult brain, which possesses a remarkable capability to repair brain damage. Recent promising p...
Source: Neural Plasticity - May 14, 2020 Category: Neurology Authors: Liu W, Wang X, O'Connor M, Wang G, Han F Tags: Neural Plast Source Type: research

Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research
Neural Plast. 2022 Mar 2;2022:3889300. doi: 10.1155/2022/3889300. eCollection 2022.ABSTRACTIschemic stroke and traumatic brain injury (TBI) are among the leading causes of death and disability worldwide with impairments ranging from mild to severe. Many therapies are aimed at improving functional and cognitive recovery by targeting neural repair but have encountered issues involving efficacy and drug delivery. As a result, therapeutic options for patients are sparse. Neurotrophic factors are one of the key mediators of neural plasticity and functional recovery. Neurotrophic factors such as brain-derived neurotrophic factor...
Source: Neural Plasticity - March 14, 2022 Category: Neurology Authors: Serena-Kaye Sims Brynna Wilken-Resman Crystal J Smith Ashley Mitchell Lilly McGonegal Catrina Sims-Robinson Source Type: research

Constitutive Expression of Adiponectin in Endothelial Progenitor Cells Protects a Rat Model of Cerebral Ischemia.
In this study, we aim to test whether we transplant a combined graft of EPCs transfected with the adiponectin gene into a rat model of cerebral ischemia could improve functional recovery after middle cerebral artery occlusion (MCAO). Sprague-Dawley (SD) rats were randomly divided into a MCAO control group, a MCAO EPC treatment group, and a MCAO LV-APN-EPC treatment group. A focal cerebral ischemia and reperfusion model was induced by the intraluminal suture method. After 2 h of reperfusion, EPCs were transplanted by injection through the tail vein. A rotarod test was conducted to assess behavioral function before MCAO an...
Source: Neural Plasticity - December 5, 2017 Category: Neurology Authors: Zhang R, Xie X, Yu Q, Feng H, Wang M, Li Y, Liu Y Tags: Neural Plast Source Type: research