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Biodistribution of bone marrow mononuclear cells after intra-arterial or intravenous transplantation in subacute stroke patients.
CONCLUSION: BMMNC labeling with technetium-99m allowed imaging for up to 24 h after intra-arterial or intravenous injection in stroke patients. PMID: 23477395 [PubMed - in process]
Source: Regenerative Medicine - March 1, 2013 Category: Genetics & Stem Cells Authors: Rosado-de-Castro PH, Schmidt Fda R, Battistella V, Lopes de Souza SA, Gutfilen B, Goldenberg RC, Kasai-Brunswick TH, Vairo L, Silva RM, Wajnberg E, Alvarenga Americano do Brasil PE, Gasparetto EL, Maiolino A, Alves-Leon SV, Andre C, Mendez-Otero R, Rodrig Tags: Regen Med Source Type: research

Safety and efficacy of cell therapies administered in the acute and subacute stages after stroke: a meta-analysis.
CONCLUSION: Although a number of therapies appear effective, many studies did not control for normal recovery (standard-care). Long-term safety also needs to be established. PMID: 27580670 [PubMed - as supplied by publisher]
Source: Regenerative Medicine - August 31, 2016 Category: Genetics & Stem Cells Authors: Unsworth DJ, Mathias JL, Dorstyn DS Tags: Regen Med Source Type: research

Cell therapies administered in the chronic phase after stroke: a meta-analysis examining safety and efficacy.
CONCLUSION: Preliminary findings suggest that some cell therapies may be relatively safe and effective, but larger double-blinded placebo-controlled studies are needed to establish the long-term risks and benefits. PMID: 27977331 [PubMed - as supplied by publisher]
Source: Regenerative Medicine - December 14, 2016 Category: Genetics & Stem Cells Authors: Unsworth DJ, Mathias JL, Dorstyn DS Tags: Regen Med Source Type: research

Intravascular cell therapy in stroke: predicting the future trends.
Abstract This short review examines the trends that have taken place during the last two decades in selecting delivery route and cell product in confirmatory preclinical stroke research. If there had been a major change, this might indicate a strategy with a high potential to enter early-phase clinical studies. The retrospective data show that intravenous cell delivery of mesenchymal stem cells remains the most popular approach in experimental research, clearly dominating early phase clinical studies. The advantages and risks of current practices are discussed in the hope that these will improve translational succ...
Source: Regenerative Medicine - December 18, 2018 Category: Genetics & Stem Cells Authors: Cui L, Moisan A, Jolkkonen J Tags: Regen Med Source Type: research

Intravascular cell therapy in stroke patients: where the cells go and what they do.
PMID: 23477388 [PubMed - in process]
Source: Regenerative Medicine - March 1, 2013 Category: Genetics & Stem Cells Authors: Korhonen M, Jolkkonen J Tags: Regen Med Source Type: research

A 'stroke' of genius: celebrating the 20-year anniversary of the Bernard Sanberg Memorial Award for Brain Repair.
PMID: 31464568 [PubMed - as supplied by publisher]
Source: Regenerative Medicine - August 28, 2019 Category: Genetics & Stem Cells Authors: Sanberg PR, Sanberg CD Tags: Regen Med Source Type: research

Understanding neural stem cell regulation < em > in vivo < /em > and applying the insights to cell therapy for strokes
Regen Med. 2021 Sep;16(9):861-870. doi: 10.2217/rme-2021-0022. Epub 2021 Sep 9.ABSTRACTThe use of neural stem cell (NSC) therapy for the treatment of stroke patients is successfully paving its way into advanced phases of large-scale clinical trials. To understand how to optimize NSC therapeutic approaches, it is fundamental to decipher the crosstalk between NSC and other cells that comprise the NSC microenvironment (niche) and regulate their function, in vivo; namely, the endothelial cells of the microvasculature. In this mini review, we first provide a concise summary of preclinical findings describing the signaling mecha...
Source: Regenerative Medicine - September 9, 2021 Category: Genetics & Stem Cells Authors: Nafiisha Genet Karen K Hirschi Source Type: research

Microfluidic 'brain-on chip' systems to supplement neurological practice: development, applications  and considerations
Regen Med. 2023 Apr 26. doi: 10.2217/rme-2022-0212. Online ahead of print.ABSTRACTAmong the greatest general challenges in bioengineering is to mimic human physiology. Advanced efforts in tissue engineering have led to sophisticated 'brain-on-chip' (BoC) microfluidic devices that can mimic structural and functional aspects of brain tissue. BoC may be used to understand the biochemical pathways of neurolgical pathologies and assess promising therapeutic agents for facilitating regenerative medicine. We evaluated the potential of microfluidic BoC devices in various neurological pathologies, such as Alzheimer's, glioblastoma,...
Source: Regenerative Medicine - May 1, 2023 Category: Genetics & Stem Cells Authors: Ryan Jarrah Karim Rizwan Nathani Shaan Bhandarkar Chibuze S Ezeudu Ryan T Nguyen Abrham Amare Usama A Aljameey Sabrina I Jarrah Archis R Bhandarkar Brian Fiani Source Type: research