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Source: International Journal of Oncology
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Total 2365 results found since Jan 2013.
Anti ‑PD‑1/PD‑L1 and anti‑CTLA‑4 associated checkpoint inhibitor pneumonitis in non‑small cell lung cancer: Occurrence, pathogenesis and risk factors (Review)
Int J Oncol. 2023 Nov;63(5):122. doi: 10.3892/ijo.2023.5570. Epub 2023 Sep 8.ABSTRACTImmune checkpoint inhibitors (ICIs) play a significant anti‑tumor role in the management of non‑small cell lung cancer. The most broadly used ICIs are anti‑programmed death 1 (PD‑1), anti‑programmed cell death‑ligand 1, and anti‑cytotoxic T lymphocyte‑associated antigen‑4 monoclonal antibody. Compared with traditional chemotherapy, ICIs have the advantages of greater efficiency and more specific targeting. However, the resulting immune‑related adverse events limit the clinical application of ICIs, especially checkpoint ...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Xiao Hu Jin Ren Qianfei Xue Rumei Luan Dongyan Ding Jie Tan Xin Su Junling Yang Source Type: research
Antimicrobial agent chloroxylenol targets β‑catenin‑mediated Wnt signaling and exerts anticancer activity in colorectal cancer
Int J Oncol. 2023 Nov;63(5):121. doi: 10.3892/ijo.2023.5569. Epub 2023 Sep 8.ABSTRACTChloroxylenol is the active ingredient of the antibacterial agent Dettol. The anticancer effect and underlying mechanisms of this compound and other common antimicrobial agents have not been clearly elucidated. In the present study, the effects of chloroxylenol, benzalkonium chloride, benzethonium chloride, triclosan and triclocarban on β‑catenin‑mediated Wnt signaling in colorectal cancer were evaluated using the SuperTOPFlash reporter assay. It was demonstrated that chloroxylenol, but not the other antimicrobial agents tested, inhib...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Qi Sun Boxin Liu Quanxue Lan Zijie Su Qiuxia Fu Lian Wang Yingying Deng Chuanli Li Vivian Weiwen Xue Shanshan Liu Xianxiong Chen Guowu Yang Desheng Lu Source Type: research
Circular RNAs in osteosarcoma: An update of recent studies (Review)
Int J Oncol. 2023 Nov;63(5):123. doi: 10.3892/ijo.2023.5571. Epub 2023 Sep 8.ABSTRACTOsteosarcoma (OS) prevailing in children and adolescents mainly occurs at the metaphysis of long bones. As it is associated with a high invasive and metastatic ability, resistance to chemotherapy, and a low 5‑year survival rate, the diagnosis and treatment of OS post a global healthy issue. Over the past decades, RNA biology has shed new light onto the pathogenesis of OS. As a type of non‑coding RNAs, circular RNAs (circRNAs) have been found to play crucial roles in cellular activities. Recently, a large number of circRNAs have been id...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Le Zeng Longzhou Liu Wen-Juan Ni Fuhua Xie Xiao-Min Leng Source Type: research
Antimicrobial agent chloroxylenol targets β‑catenin‑mediated Wnt signaling and exerts anticancer activity in colorectal cancer
Int J Oncol. 2023 Nov;63(5):121. doi: 10.3892/ijo.2023.5569. Epub 2023 Sep 8.ABSTRACTChloroxylenol is the active ingredient of the antibacterial agent Dettol. The anticancer effect and underlying mechanisms of this compound and other common antimicrobial agents have not been clearly elucidated. In the present study, the effects of chloroxylenol, benzalkonium chloride, benzethonium chloride, triclosan and triclocarban on β‑catenin‑mediated Wnt signaling in colorectal cancer were evaluated using the SuperTOPFlash reporter assay. It was demonstrated that chloroxylenol, but not the other antimicrobial agents tested, inhib...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Qi Sun Boxin Liu Quanxue Lan Zijie Su Qiuxia Fu Lian Wang Yingying Deng Chuanli Li Vivian Weiwen Xue Shanshan Liu Xianxiong Chen Guowu Yang Desheng Lu Source Type: research
Circular RNAs in osteosarcoma: An update of recent studies (Review)
Int J Oncol. 2023 Nov;63(5):123. doi: 10.3892/ijo.2023.5571. Epub 2023 Sep 8.ABSTRACTOsteosarcoma (OS) prevailing in children and adolescents mainly occurs at the metaphysis of long bones. As it is associated with a high invasive and metastatic ability, resistance to chemotherapy, and a low 5‑year survival rate, the diagnosis and treatment of OS post a global healthy issue. Over the past decades, RNA biology has shed new light onto the pathogenesis of OS. As a type of non‑coding RNAs, circular RNAs (circRNAs) have been found to play crucial roles in cellular activities. Recently, a large number of circRNAs have been id...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Le Zeng Longzhou Liu Wen-Juan Ni Fuhua Xie Xiao-Min Leng Source Type: research
Roles of salt ‑inducible kinases in cancer (Review)
Int J Oncol. 2023 Nov;63(5):118. doi: 10.3892/ijo.2023.5566. Epub 2023 Sep 1.ABSTRACTSalt inducible kinases (SIKs) with three subtypes SIK1, SIK2 and SIK3, belong to the AMP‑activated protein kinase family. They are expressed ubiquitously in humans. Under normal circumstances, SIK1 regulates adrenocortical function in response to high salt or adrenocorticotropic hormone stimulation, SIK2 is involved in cell metabolism, controlling insulin signaling and gluconeogenesis and SIK3 coordinates with the mTOR complex, promoting cancer. The dysregulation of SIKs has been widely detected in various types of cancers. Based on most...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Shenghui Feng Fangyi Wei Haoran Shi Shen Chen Bangqi Wang Deqiang Huang Lingyu Luo Source Type: research
RYBP contributes to improved prognosis in colorectal cancer via regulation of cell cycle, apoptosis and oxaliplatin sensitivity
Int J Oncol. 2023 Nov;63(5):120. doi: 10.3892/ijo.2023.5568. Epub 2023 Sep 1.ABSTRACTRing1 and YY‑1 binding protein (RYBP) is a member of the polycomb repressive complex 1 and serves as a transcriptional suppressor via epigenetic modification. RYBP has a tumour‑suppressive role in solid tumours, but its function in colorectal cancer (CRC) remains unknown. The present study evaluated the expression of RYBP using immunohistochemistry in 140 cases of primary CRC and 11 patient‑matched cases of liver metastases. Using CRC cell lines with different TP53 gene status such as HCT116 (TP53wt/wt), HCT116 (TP53‑/‑), SW48 an...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Takashi Morinaka Nozomu Sakai Tsukasa Takayashiki Satoshi Kuboki Shigetsugu Takano Gaku Ohira Hisahiro Matsubara Masayuki Ohtsuka Source Type: research
Human cytomegalovirus infection enhances 5 ‑lipoxygenase and cycloxygenase‑2 expression in colorectal cancer
Int J Oncol. 2023 Nov;63(5):116. doi: 10.3892/ijo.2023.5564. Epub 2023 Sep 1.ABSTRACTColorectal cancer (CRC) is one of the most common and fatal types of cancer. Inflammation promotes CRC development, however, the underlying etiological factors are unknown. Human cytomegalovirus (HCMV), a virus that induces inflammation and other cancer hallmarks, has been detected in several types of malignancy, including CRC. The present study investigated whether HCMV infection was associated with expression of the pro‑inflammatory enzymes 5‑lipoxygenase (5‑LO) and cyclooxygenase‑2 (COX‑2) and other molecular, genetic and clin...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Mattia Russel Pantalone Nerea Martin Almazan Rossano Lattanzio Chato Taher Simone De Fabritiis Silvia Valentinuzzi Faraz Bishehsari Mahboobeh Mahdavinia Fabio Verginelli Afsar Rahbar Renato Mariani-Costantini Cecilia S öderberg-Naucler Source Type: research
CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia ‑induced invasion and therapeutic resistance
Int J Oncol. 2023 Nov;63(5):117. doi: 10.3892/ijo.2023.5565. Epub 2023 Sep 1.ABSTRACTGlioblastoma (GBM) is the most common and malignant primary brain tumor affecting adults and remains incurable. The mitochondrial coiled‑coil‑helix‑coiled‑coil‑helix domain‑containing protein 2 (CHCHD2) has been demonstrated to mediate mitochondrial respiration, nuclear gene expression and cell migration; however, evidence of this in GBM is lacking. In the present study, it was hypothesized that CHCHD2 may play a functional role in U87 GBM cells expressing the constitutively active epidermal growth factor receptor variant III (...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Jan C Lumibao Payton L Haak Vladimir L Kolossov Jee-Wei Emily Chen Jeremy Stutchman Alejandra Ruiz Mayandi Sivaguru Jann N Sarkaria Brendan A C Harley Andrew J Steelman H Rex Gaskins Source Type: research
Mechanism of multidrug resistance to chemotherapy mediated by P ‑glycoprotein (Review)
Int J Oncol. 2023 Nov;63(5):119. doi: 10.3892/ijo.2023.5567. Epub 2023 Sep 1.ABSTRACTMultidrug resistance (MDR) seriously limits the clinical application of chemotherapy. A mechanism underlying MDR is the overexpression of efflux transporters associated with chemotherapeutic drugs. P‑glycoprotein (P‑gp) is an ATP‑binding cassette (ABC) transporter, which promotes MDR by pumping out chemotherapeutic drugs and reducing their intracellular concentration. To date, overexpression of P‑gp has been detected in various types of chemoresistant cancer and inhibiting P‑gp‑related MDR has been suggested. The present review...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Yichen Tian Yongrong Lei Yani Wang Jiejuan Lai Jianhua Wang Feng Xia Source Type: research
Roles of salt ‑inducible kinases in cancer (Review)
Int J Oncol. 2023 Nov;63(5):118. doi: 10.3892/ijo.2023.5566. Epub 2023 Sep 1.ABSTRACTSalt inducible kinases (SIKs) with three subtypes SIK1, SIK2 and SIK3, belong to the AMP‑activated protein kinase family. They are expressed ubiquitously in humans. Under normal circumstances, SIK1 regulates adrenocortical function in response to high salt or adrenocorticotropic hormone stimulation, SIK2 is involved in cell metabolism, controlling insulin signaling and gluconeogenesis and SIK3 coordinates with the mTOR complex, promoting cancer. The dysregulation of SIKs has been widely detected in various types of cancers. Based on most...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Shenghui Feng Fangyi Wei Haoran Shi Shen Chen Bangqi Wang Deqiang Huang Lingyu Luo Source Type: research
RYBP contributes to improved prognosis in colorectal cancer via regulation of cell cycle, apoptosis and oxaliplatin sensitivity
Int J Oncol. 2023 Nov;63(5):120. doi: 10.3892/ijo.2023.5568. Epub 2023 Sep 1.ABSTRACTRing1 and YY‑1 binding protein (RYBP) is a member of the polycomb repressive complex 1 and serves as a transcriptional suppressor via epigenetic modification. RYBP has a tumour‑suppressive role in solid tumours, but its function in colorectal cancer (CRC) remains unknown. The present study evaluated the expression of RYBP using immunohistochemistry in 140 cases of primary CRC and 11 patient‑matched cases of liver metastases. Using CRC cell lines with different TP53 gene status such as HCT116 (TP53wt/wt), HCT116 (TP53‑/‑), SW48 an...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Takashi Morinaka Nozomu Sakai Tsukasa Takayashiki Satoshi Kuboki Shigetsugu Takano Gaku Ohira Hisahiro Matsubara Masayuki Ohtsuka Source Type: research
Human cytomegalovirus infection enhances 5 ‑lipoxygenase and cycloxygenase‑2 expression in colorectal cancer
Int J Oncol. 2023 Nov;63(5):116. doi: 10.3892/ijo.2023.5564. Epub 2023 Sep 1.ABSTRACTColorectal cancer (CRC) is one of the most common and fatal types of cancer. Inflammation promotes CRC development, however, the underlying etiological factors are unknown. Human cytomegalovirus (HCMV), a virus that induces inflammation and other cancer hallmarks, has been detected in several types of malignancy, including CRC. The present study investigated whether HCMV infection was associated with expression of the pro‑inflammatory enzymes 5‑lipoxygenase (5‑LO) and cyclooxygenase‑2 (COX‑2) and other molecular, genetic and clin...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Mattia Russel Pantalone Nerea Martin Almazan Rossano Lattanzio Chato Taher Simone De Fabritiis Silvia Valentinuzzi Faraz Bishehsari Mahboobeh Mahdavinia Fabio Verginelli Afsar Rahbar Renato Mariani-Costantini Cecilia S öderberg-Naucler Source Type: research
CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia ‑induced invasion and therapeutic resistance
Int J Oncol. 2023 Nov;63(5):117. doi: 10.3892/ijo.2023.5565. Epub 2023 Sep 1.ABSTRACTGlioblastoma (GBM) is the most common and malignant primary brain tumor affecting adults and remains incurable. The mitochondrial coiled‑coil‑helix‑coiled‑coil‑helix domain‑containing protein 2 (CHCHD2) has been demonstrated to mediate mitochondrial respiration, nuclear gene expression and cell migration; however, evidence of this in GBM is lacking. In the present study, it was hypothesized that CHCHD2 may play a functional role in U87 GBM cells expressing the constitutively active epidermal growth factor receptor variant III (...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Jan C Lumibao Payton L Haak Vladimir L Kolossov Jee-Wei Emily Chen Jeremy Stutchman Alejandra Ruiz Mayandi Sivaguru Jann N Sarkaria Brendan A C Harley Andrew J Steelman H Rex Gaskins Source Type: research
Mechanism of multidrug resistance to chemotherapy mediated by P ‑glycoprotein (Review)
Int J Oncol. 2023 Nov;63(5):119. doi: 10.3892/ijo.2023.5567. Epub 2023 Sep 1.ABSTRACTMultidrug resistance (MDR) seriously limits the clinical application of chemotherapy. A mechanism underlying MDR is the overexpression of efflux transporters associated with chemotherapeutic drugs. P‑glycoprotein (P‑gp) is an ATP‑binding cassette (ABC) transporter, which promotes MDR by pumping out chemotherapeutic drugs and reducing their intracellular concentration. To date, overexpression of P‑gp has been detected in various types of chemoresistant cancer and inhibiting P‑gp‑related MDR has been suggested. The present review...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Yichen Tian Yongrong Lei Yani Wang Jiejuan Lai Jianhua Wang Feng Xia Source Type: research
