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Source: Neurosurgical Focus

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Total 545 results found since Jan 2013.

Transcranial eddy current damping sensors for detection and imaging of hemorrhagic stroke: feasibility in benchtop experimentation
CONCLUSIONS: Benchtop experiments demonstrated the proof of concept of the ECD sensor for rapid transcranial hemorrhagic stroke diagnosis. Future studies with live human participants are warranted to fully establish the feasibility findings derived from this study.PMID:34198251 | DOI:10.3171/2021.4.FOCUS21121
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Shane Shahrestani Ben A Strickland Joshua Bakhsheshian William J Mack Arthur W Toga Nerses Sanossian Yu-Chong Tai Gabriel Zada Source Type: research

Does stroke etiology influence outcome in the posterior circulation? An analysis of 107 consecutive acute basilar occlusion thrombectomies
CONCLUSIONS: In the current study, demographic and clinical results for acute BAO showed that compared with intrinsic disease, thromboembolic disease is a more common mechanism of acute BAO, with 78% of patients undergoing thrombectomy alone. However, there was no significant difference in revascularization and outcome results between patients with embolic disease and those with intrinsic disease.PMID:34198247 | DOI:10.3171/2021.4.FOCUS2189
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Roberta K Sefcik Daniel A Tonetti Shashvat M Desai Stephanie M Casillo Michael J Lang Ashutosh P Jadhav Bradley A Gross Source Type: research

Transcranial eddy current damping sensors for detection and imaging of hemorrhagic stroke: feasibility in benchtop experimentation
CONCLUSIONS: Benchtop experiments demonstrated the proof of concept of the ECD sensor for rapid transcranial hemorrhagic stroke diagnosis. Future studies with live human participants are warranted to fully establish the feasibility findings derived from this study.PMID:34198251 | DOI:10.3171/2021.4.FOCUS21121
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Shane Shahrestani Ben A Strickland Joshua Bakhsheshian William J Mack Arthur W Toga Nerses Sanossian Yu-Chong Tai Gabriel Zada Source Type: research

Does stroke etiology influence outcome in the posterior circulation? An analysis of 107 consecutive acute basilar occlusion thrombectomies
CONCLUSIONS: In the current study, demographic and clinical results for acute BAO showed that compared with intrinsic disease, thromboembolic disease is a more common mechanism of acute BAO, with 78% of patients undergoing thrombectomy alone. However, there was no significant difference in revascularization and outcome results between patients with embolic disease and those with intrinsic disease.PMID:34198247 | DOI:10.3171/2021.4.FOCUS2189
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Roberta K Sefcik Daniel A Tonetti Shashvat M Desai Stephanie M Casillo Michael J Lang Ashutosh P Jadhav Bradley A Gross Source Type: research

Transcranial eddy current damping sensors for detection and imaging of hemorrhagic stroke: feasibility in benchtop experimentation
CONCLUSIONS: Benchtop experiments demonstrated the proof of concept of the ECD sensor for rapid transcranial hemorrhagic stroke diagnosis. Future studies with live human participants are warranted to fully establish the feasibility findings derived from this study.PMID:34198251 | DOI:10.3171/2021.4.FOCUS21121
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Shane Shahrestani Ben A Strickland Joshua Bakhsheshian William J Mack Arthur W Toga Nerses Sanossian Yu-Chong Tai Gabriel Zada Source Type: research

Does stroke etiology influence outcome in the posterior circulation? An analysis of 107 consecutive acute basilar occlusion thrombectomies
CONCLUSIONS: In the current study, demographic and clinical results for acute BAO showed that compared with intrinsic disease, thromboembolic disease is a more common mechanism of acute BAO, with 78% of patients undergoing thrombectomy alone. However, there was no significant difference in revascularization and outcome results between patients with embolic disease and those with intrinsic disease.PMID:34198247 | DOI:10.3171/2021.4.FOCUS2189
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Roberta K Sefcik Daniel A Tonetti Shashvat M Desai Stephanie M Casillo Michael J Lang Ashutosh P Jadhav Bradley A Gross Source Type: research

Transcranial eddy current damping sensors for detection and imaging of hemorrhagic stroke: feasibility in benchtop experimentation
CONCLUSIONS: Benchtop experiments demonstrated the proof of concept of the ECD sensor for rapid transcranial hemorrhagic stroke diagnosis. Future studies with live human participants are warranted to fully establish the feasibility findings derived from this study.PMID:34198251 | DOI:10.3171/2021.4.FOCUS21121
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Shane Shahrestani Ben A Strickland Joshua Bakhsheshian William J Mack Arthur W Toga Nerses Sanossian Yu-Chong Tai Gabriel Zada Source Type: research

Does stroke etiology influence outcome in the posterior circulation? An analysis of 107 consecutive acute basilar occlusion thrombectomies
CONCLUSIONS: In the current study, demographic and clinical results for acute BAO showed that compared with intrinsic disease, thromboembolic disease is a more common mechanism of acute BAO, with 78% of patients undergoing thrombectomy alone. However, there was no significant difference in revascularization and outcome results between patients with embolic disease and those with intrinsic disease.PMID:34198247 | DOI:10.3171/2021.4.FOCUS2189
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Roberta K Sefcik Daniel A Tonetti Shashvat M Desai Stephanie M Casillo Michael J Lang Ashutosh P Jadhav Bradley A Gross Source Type: research

Transcranial eddy current damping sensors for detection and imaging of hemorrhagic stroke: feasibility in benchtop experimentation
CONCLUSIONS: Benchtop experiments demonstrated the proof of concept of the ECD sensor for rapid transcranial hemorrhagic stroke diagnosis. Future studies with live human participants are warranted to fully establish the feasibility findings derived from this study.PMID:34198251 | DOI:10.3171/2021.4.FOCUS21121
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Shane Shahrestani Ben A Strickland Joshua Bakhsheshian William J Mack Arthur W Toga Nerses Sanossian Yu-Chong Tai Gabriel Zada Source Type: research

Does stroke etiology influence outcome in the posterior circulation? An analysis of 107 consecutive acute basilar occlusion thrombectomies
CONCLUSIONS: In the current study, demographic and clinical results for acute BAO showed that compared with intrinsic disease, thromboembolic disease is a more common mechanism of acute BAO, with 78% of patients undergoing thrombectomy alone. However, there was no significant difference in revascularization and outcome results between patients with embolic disease and those with intrinsic disease.PMID:34198247 | DOI:10.3171/2021.4.FOCUS2189
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Roberta K Sefcik Daniel A Tonetti Shashvat M Desai Stephanie M Casillo Michael J Lang Ashutosh P Jadhav Bradley A Gross Source Type: research

Effect of glibenclamide on the prevention of secondary brain injury following ischemic stroke in humans.
Abstract Cerebral edema and hemorrhagic conversion are common, potentially devastating complications of ischemic stroke and are associated with high rates of mortality and poor functional outcomes. Recent work exploring the molecular pathophysiology of the neurogliovascular unit in ischemic stroke suggests that deranged cellular ion homeostasis due to altered function and regulation of ion pumps, channels, and secondary active transporters plays an integral role in the development of cytotoxic and vasogenic edema and hemorrhagic conversion. Among these proteins involved in ion homeostasis, the ischemia-induced, no...
Source: Neurosurgical Focus - January 1, 2014 Category: Neurosurgery Authors: Khanna A, Walcott BP, Kahle KT, Simard JM Tags: Neurosurg Focus Source Type: research

Woodrow Wilson's hidden stroke of 1919: the impact of patient-physician confidentiality on United States foreign policy.
Abstract World War I catapulted the United States from traditional isolationism to international involvement in a major European conflict. Woodrow Wilson envisaged a permanent American imprint on democracy in world affairs through participation in the League of Nations. Amid these defining events, Wilson suffered a major ischemic stroke on October 2, 1919, which left him incapacitated. What was probably his fourth and most devastating stroke was diagnosed and treated by his friend and personal physician, Admiral Cary Grayson. Grayson, who had tremendous personal and professional loyalty to Wilson, kept the severit...
Source: Neurosurgical Focus - July 1, 2015 Category: Neurosurgery Authors: Menger RP, Storey CM, Guthikonda B, Missios S, Nanda A, Cooper JM Tags: Neurosurg Focus Source Type: research

Neurorestoration after stroke.
Abstract Recent advancements in stem cell biology and neuromodulation have ushered in a battery of new neurorestorative therapies for ischemic stroke. While the understanding of stroke pathophysiology has matured, the ability to restore patients' quality of life remains inadequate. New therapeutic approaches, including cell transplantation and neurostimulation, focus on reestablishing the circuits disrupted by ischemia through multidimensional mechanisms to improve neuroplasticity and remodeling. The authors provide a broad overview of stroke pathophysiology and existing therapies to highlight the scientific and c...
Source: Neurosurgical Focus - April 30, 2016 Category: Neurosurgery Authors: Azad TD, Veeravagu A, Steinberg GK Tags: Neurosurg Focus Source Type: research

Neuroprotective strategies and the underlying molecular basis of cerebrovascular stroke.
Abstract Stroke is a leading cause of disability in the US. Although there has been significant progress in the area of medical and surgical thrombolytic technologies, neuroprotective agents to prevent secondary cerebral injury and to minimize disability remain limited. Only limited success has been reported in preclinical and clinical trials evaluating a variety of compounds. In this review, the authors discuss the most up-to-date information regarding the underlying molecular biology of stroke as well as strategies that aim to mitigate this complex signaling cascade. Results of historical research trials involvi...
Source: Neurosurgical Focus - April 1, 2017 Category: Neurosurgery Authors: Karsy M, Brock A, Guan J, Taussky P, Kalani MY, Park MS Tags: Neurosurg Focus Source Type: research

Expanding the treatment window for ischemic stroke through the application of novel system-based technology.
Abstract Recent randomized controlled trials have demonstrated the superiority of endovascular treatment (ET) over medical management in the treatment of acute ischemic stroke patients with anterior circulation emergent large vessel occlusions (ELVOs). Due to such accumulating evidence, expanding ET has become of paramount importance. Advancements in modern technology have enabled the use of mobile stroke units, telestroke networks, mobile neuroendovascular teams, and smartphone applications that shorten the time window to treatment and, thus, make patients more amenable to ET. Additionally, modifying stroke-scree...
Source: Neurosurgical Focus - April 1, 2017 Category: Neurosurgery Authors: El-Ghanem M, Al-Mufti F, Thulasi V, Singh IP, Gandhi C Tags: Neurosurg Focus Source Type: research