Filtered By:
Source: Neurosurgical Focus

This page shows you your search results in order of relevance. This is page number 11.

Order by Relevance | Date

Total 545 results found since Jan 2013.

Optogenetic modulation in stroke recovery.
Abstract Stroke is one of the leading contributors to morbidity, mortality, and health care costs in the United States. Although several preclinical strategies have shown promise in the laboratory, few have succeeded in the clinical setting. Optogenetics represents a promising molecular tool, which enables highly specific circuit-level neuromodulation. Here, the conceptual background and preclinical body of evidence for optogenetics are reviewed, and translational considerations in stroke recovery are discussed. PMID: 27132527 [PubMed - in process]
Source: Neurosurgical Focus - April 30, 2016 Category: Neurosurgery Authors: Pendharkar AV, Levy SL, Ho AL, Sussman ES, Cheng MY, Steinberg GK Tags: Neurosurg Focus Source Type: research

Management of acute ischemic stroke due to tandem occlusion: should endovascular recanalization of the extracranial or intracranial occlusive lesion be done first?
CONCLUSIONS Tandem occlusions present treatment challenges, but high recanalization rates were possible in the present series using acute carotid artery stenting and mechanical thrombectomy concurrently. Proximal-to-distal and aspiration approaches were most commonly used because they were safe, efficacious, and feasible. Further study in the setting of a randomized controlled trial is needed to determine the best sequence for the treatment approach and the best technology for tandem occlusion. PMID: 28366065 [PubMed - in process]
Source: Neurosurgical Focus - April 1, 2017 Category: Neurosurgery Authors: Rangel-Castilla L, Rajah GB, Shakir HJ, Shallwani H, Gandhi S, Davies JM, Snyder KV, Levy EI, Siddiqui AH Tags: Neurosurg Focus Source Type: research

Stent technology in ischemic stroke.
Abstract Atherosclerotic disease of the cerebral vasculature is a major cause of stroke worldwide. Atherosclerosis that is refractory to best medical management may require revascularization. In these instances, endovascular treatment provides a popular and safe alternative to open surgical techniques. The authors provide an overview of stent technology in the treatment of ischemic stroke, discussing the major studies evaluating stenting for extracranial carotid artery, vertebral artery, and intracranial atherosclerotic disease. The authors describe the commonly used stents with respect to their individual charact...
Source: Neurosurgical Focus - April 1, 2017 Category: Neurosurgery Authors: Yoon NK, Awad AW, Kalani MY, Taussky P, Park MS Tags: Neurosurg Focus Source Type: research

Trends in acute ischemic stroke treatments and mortality in the United States from 2012 to 2018
CONCLUSIONS: From 2012 to 2018, use of tPA and MT increased significantly, irrespective of age, while mortality decreased in the entire AIS population. The most dramatic decrease in mortality was seen in the MT-treated population. Age-standardized mortality improved only in patients older than 70 years, with no change in younger patients.PMID:34198248 | DOI:10.3171/2021.4.FOCUS21117
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Sharath Kumar Anand William J Benjamin Arjun Rohit Adapa Jiwon V Park D Andrew Wilkinson Badih J Daou James F Burke Aditya S Pandey Source Type: research

Direct thrombectomy versus bridging thrombolysis with mechanical thrombectomy in middle cerebral artery stroke: a real-world analysis through National Inpatient Sample data
CONCLUSIONS: In the analysis of the NIS database, the MT+IVT group had significantly higher rates of minimal disability at the time of hospital discharge versus the MT-alone group, despite a higher rate of ICH. The question of whether to treat patients with MT+IVT rather than MT alone is currently being addressed in ongoing prospective clinical trials (SWIFT-DIRECT [NCT03494920], MR CLEAN-NO IV [ISRCTN80619088], and DIRECT-SAFE [NCT03494920]). The results of these studies will contribute to greater understanding and progressive improvement in outcomes for AIS patients.PMID:34198246 | DOI:10.3171/2021.4.FOCUS21132
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Sandeep Kandregula Amey R Savardekar Pankaj Sharma Jerry McLarty Jennifer Kosty Krystle Trosclair Hugo Cuellar Bharat Guthikonda Source Type: research

Trends in acute ischemic stroke treatments and mortality in the United States from 2012 to 2018
CONCLUSIONS: From 2012 to 2018, use of tPA and MT increased significantly, irrespective of age, while mortality decreased in the entire AIS population. The most dramatic decrease in mortality was seen in the MT-treated population. Age-standardized mortality improved only in patients older than 70 years, with no change in younger patients.PMID:34198248 | DOI:10.3171/2021.4.FOCUS21117
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Sharath Kumar Anand William J Benjamin Arjun Rohit Adapa Jiwon V Park D Andrew Wilkinson Badih J Daou James F Burke Aditya S Pandey Source Type: research

Direct thrombectomy versus bridging thrombolysis with mechanical thrombectomy in middle cerebral artery stroke: a real-world analysis through National Inpatient Sample data
CONCLUSIONS: In the analysis of the NIS database, the MT+IVT group had significantly higher rates of minimal disability at the time of hospital discharge versus the MT-alone group, despite a higher rate of ICH. The question of whether to treat patients with MT+IVT rather than MT alone is currently being addressed in ongoing prospective clinical trials (SWIFT-DIRECT [NCT03494920], MR CLEAN-NO IV [ISRCTN80619088], and DIRECT-SAFE [NCT03494920]). The results of these studies will contribute to greater understanding and progressive improvement in outcomes for AIS patients.PMID:34198246 | DOI:10.3171/2021.4.FOCUS21132
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Sandeep Kandregula Amey R Savardekar Pankaj Sharma Jerry McLarty Jennifer Kosty Krystle Trosclair Hugo Cuellar Bharat Guthikonda Source Type: research

Trends in acute ischemic stroke treatments and mortality in the United States from 2012 to 2018
CONCLUSIONS: From 2012 to 2018, use of tPA and MT increased significantly, irrespective of age, while mortality decreased in the entire AIS population. The most dramatic decrease in mortality was seen in the MT-treated population. Age-standardized mortality improved only in patients older than 70 years, with no change in younger patients.PMID:34198248 | DOI:10.3171/2021.4.FOCUS21117
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Sharath Kumar Anand William J Benjamin Arjun Rohit Adapa Jiwon V Park D Andrew Wilkinson Badih J Daou James F Burke Aditya S Pandey Source Type: research

Direct thrombectomy versus bridging thrombolysis with mechanical thrombectomy in middle cerebral artery stroke: a real-world analysis through National Inpatient Sample data
CONCLUSIONS: In the analysis of the NIS database, the MT+IVT group had significantly higher rates of minimal disability at the time of hospital discharge versus the MT-alone group, despite a higher rate of ICH. The question of whether to treat patients with MT+IVT rather than MT alone is currently being addressed in ongoing prospective clinical trials (SWIFT-DIRECT [NCT03494920], MR CLEAN-NO IV [ISRCTN80619088], and DIRECT-SAFE [NCT03494920]). The results of these studies will contribute to greater understanding and progressive improvement in outcomes for AIS patients.PMID:34198246 | DOI:10.3171/2021.4.FOCUS21132
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Sandeep Kandregula Amey R Savardekar Pankaj Sharma Jerry McLarty Jennifer Kosty Krystle Trosclair Hugo Cuellar Bharat Guthikonda Source Type: research

Trends in acute ischemic stroke treatments and mortality in the United States from 2012 to 2018
CONCLUSIONS: From 2012 to 2018, use of tPA and MT increased significantly, irrespective of age, while mortality decreased in the entire AIS population. The most dramatic decrease in mortality was seen in the MT-treated population. Age-standardized mortality improved only in patients older than 70 years, with no change in younger patients.PMID:34198248 | DOI:10.3171/2021.4.FOCUS21117
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Sharath Kumar Anand William J Benjamin Arjun Rohit Adapa Jiwon V Park D Andrew Wilkinson Badih J Daou James F Burke Aditya S Pandey Source Type: research

Direct thrombectomy versus bridging thrombolysis with mechanical thrombectomy in middle cerebral artery stroke: a real-world analysis through National Inpatient Sample data
CONCLUSIONS: In the analysis of the NIS database, the MT+IVT group had significantly higher rates of minimal disability at the time of hospital discharge versus the MT-alone group, despite a higher rate of ICH. The question of whether to treat patients with MT+IVT rather than MT alone is currently being addressed in ongoing prospective clinical trials (SWIFT-DIRECT [NCT03494920], MR CLEAN-NO IV [ISRCTN80619088], and DIRECT-SAFE [NCT03494920]). The results of these studies will contribute to greater understanding and progressive improvement in outcomes for AIS patients.PMID:34198246 | DOI:10.3171/2021.4.FOCUS21132
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Sandeep Kandregula Amey R Savardekar Pankaj Sharma Jerry McLarty Jennifer Kosty Krystle Trosclair Hugo Cuellar Bharat Guthikonda Source Type: research

Trends in acute ischemic stroke treatments and mortality in the United States from 2012 to 2018
CONCLUSIONS: From 2012 to 2018, use of tPA and MT increased significantly, irrespective of age, while mortality decreased in the entire AIS population. The most dramatic decrease in mortality was seen in the MT-treated population. Age-standardized mortality improved only in patients older than 70 years, with no change in younger patients.PMID:34198248 | DOI:10.3171/2021.4.FOCUS21117
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Sharath Kumar Anand William J Benjamin Arjun Rohit Adapa Jiwon V Park D Andrew Wilkinson Badih J Daou James F Burke Aditya S Pandey Source Type: research

Direct thrombectomy versus bridging thrombolysis with mechanical thrombectomy in middle cerebral artery stroke: a real-world analysis through National Inpatient Sample data
CONCLUSIONS: In the analysis of the NIS database, the MT+IVT group had significantly higher rates of minimal disability at the time of hospital discharge versus the MT-alone group, despite a higher rate of ICH. The question of whether to treat patients with MT+IVT rather than MT alone is currently being addressed in ongoing prospective clinical trials (SWIFT-DIRECT [NCT03494920], MR CLEAN-NO IV [ISRCTN80619088], and DIRECT-SAFE [NCT03494920]). The results of these studies will contribute to greater understanding and progressive improvement in outcomes for AIS patients.PMID:34198246 | DOI:10.3171/2021.4.FOCUS21132
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Sandeep Kandregula Amey R Savardekar Pankaj Sharma Jerry McLarty Jennifer Kosty Krystle Trosclair Hugo Cuellar Bharat Guthikonda Source Type: research

Trends in acute ischemic stroke treatments and mortality in the United States from 2012 to 2018
CONCLUSIONS: From 2012 to 2018, use of tPA and MT increased significantly, irrespective of age, while mortality decreased in the entire AIS population. The most dramatic decrease in mortality was seen in the MT-treated population. Age-standardized mortality improved only in patients older than 70 years, with no change in younger patients.PMID:34198248 | DOI:10.3171/2021.4.FOCUS21117
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Sharath Kumar Anand William J Benjamin Arjun Rohit Adapa Jiwon V Park D Andrew Wilkinson Badih J Daou James F Burke Aditya S Pandey Source Type: research

Direct thrombectomy versus bridging thrombolysis with mechanical thrombectomy in middle cerebral artery stroke: a real-world analysis through National Inpatient Sample data
CONCLUSIONS: In the analysis of the NIS database, the MT+IVT group had significantly higher rates of minimal disability at the time of hospital discharge versus the MT-alone group, despite a higher rate of ICH. The question of whether to treat patients with MT+IVT rather than MT alone is currently being addressed in ongoing prospective clinical trials (SWIFT-DIRECT [NCT03494920], MR CLEAN-NO IV [ISRCTN80619088], and DIRECT-SAFE [NCT03494920]). The results of these studies will contribute to greater understanding and progressive improvement in outcomes for AIS patients.PMID:34198246 | DOI:10.3171/2021.4.FOCUS21132
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Sandeep Kandregula Amey R Savardekar Pankaj Sharma Jerry McLarty Jennifer Kosty Krystle Trosclair Hugo Cuellar Bharat Guthikonda Source Type: research