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Source: Stroke
Therapy: Statin Therapy

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Total 59 results found since Jan 2013.

Dynamic Permeability and Quantitative Susceptibility: Related Imaging Biomarkers in Cerebral Cavernous Malformations Brief Reports
Conclusions— The correlation between quantitative susceptibility mapping and dynamic contrast-enhanced quantitative perfusion suggests that the phenomena of permeability and iron deposition are related in CCM; hence, more leaky lesions also manifest a more cumulative iron burden. These techniques might be used as biomarkers to monitor the course of this disease and the effect of therapy.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Mikati, A. G., Tan, H., Shenkar, R., Li, L., Zhang, L., Guo, X., Larsson, H. B. W., Shi, C., Liu, T., Wang, Y., Shah, A., Edelman, R. R., Christoforidis, G., Awad, I. Tags: CT and MRI, Computerized tomography and Magnetic Resonance Imaging, Other imaging Brief Reports Source Type: research

Apolipoprotein E, Statins, and Risk of Intracerebral Hemorrhage Clinical Sciences
Conclusions— Statin use does not seem to attenuate the association of HC with decreased risk for nonlobar ICH. Our data support a gene-by-drug effect for lobar ICH, but larger sample sizes are needed to confirm the association before any clinical change is warranted. Clinical Trial Registration— URL: http://clinicaltrials.gov. Unique identifier: NCT00930280.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Woo, D., Deka, R., Falcone, G. J., Flaherty, M. L., Haverbusch, M., Martini, S. R., Greenberg, S. M., Ayres, A. M., Sauerbeck, L., Kissela, B. M., Kleindorfer, D. O., Moomaw, C. J., Anderson, C. D., Broderick, J. P., Rosand, J., Langefeld, C. D., Woo, J. Tags: Embolic stroke Clinical Sciences Source Type: research

Extended-Release Niacin Therapy and Risk of Ischemic Stroke in Patients With Cardiovascular Disease: The Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcome (AIM-HIGH) Trial Major Clinical Trials
Conclusions— Although there were numerically more ischemic strokes with addition of ERN to simvastatin that reached nominal significance, the number was small, and multivariable analysis accounting for known risk factors did not support a significant association between niacin and ischemic stroke risk. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00120289.
Source: Stroke - September 23, 2013 Category: Neurology Authors: Teo, K. K., Goldstein, L. B., Chaitman, B. R., Grant, S., Weintraub, W. S., Anderson, D. C., Sila, C. A., Cruz-Flores, S., Padley, R. J., Kostuk, W. J., Boden, W. E., on behalf of the AIM-HIGH Investigators Tags: Secondary prevention, Risk Factors, Acute Cerebral Infarction, Other Stroke Treatment - Medical Major Clinical Trials Source Type: research

Reduction in Early Stroke Risk in Carotid Stenosis With Transient Ischemic Attack Associated With Statin Treatment Clinical Sciences
Conclusions— In acute symptomatic carotid stenosis, statin pretreatment was associated with reduced stroke risk, consistent with findings from randomized trials in acute coronary syndromes. These data support the hypothesis that statins started acutely after TIA symptom onset may also be beneficial to prevent early stroke. Randomized trials addressing this question are required.
Source: Stroke - September 23, 2013 Category: Neurology Authors: Merwick, A., Albers, G. W., Arsava, E. M., Ay, H., Calvet, D., Coutts, S. B., Cucchiara, B. L., Demchuk, A. M., Giles, M. F., Mas, J.-L., Olivot, J. M., Purroy, F., Rothwell, P. M., Saver, J. L., Sharma, V. K., Tsivgoulis, G., Kelly, P. J. Tags: Secondary prevention, Carotid Stenosis, Other Stroke Treatment - Medical, Lipid and lipoprotein metabolism Clinical Sciences Source Type: research

Urgent Best Medical Therapy May Obviate the Need for Urgent Surgery in Patients With Symptomatic Carotid Stenosis Clinical Sciences
Conclusions— CEA can be performed in the subacute period without significantly increasing the operative risk. The urgent best medical treatment was associated with significant reduction in the risk of early NR in CEA patients. It seems that urgent aggressive best medical treatment may obviate the need for urgent CEA.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Shahidi, S., Owen-Falkenberg, A., Hjerpsted, U., Rai, A., Ellemann, K. Tags: Secondary prevention, Antiplatelets, Carotid endarterectomy, Transient Ischemic Attacks Clinical Sciences Source Type: research

Association of Prestroke Statin Use and Lipid Levels With Outcome of Intracerebral Hemorrhage Brief Reports
Conclusions— Premorbid statin use did not affect the outcome of ICH, but lower low-density lipoprotein levels were associated with higher in-hospital mortality.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Mustanoja, S., Strbian, D., Putaala, J., Meretoja, A., Curtze, S., Haapaniemi, E., Sairanen, T., Hietikko, R., Siren, J., Kaste, M., Tatlisumak, T. Tags: Brief Reports Source Type: research

Ultra-Sensitive Molecular MRI of Vascular Cell Adhesion Molecule-1 Reveals a Dynamic Inflammatory Penumbra After Strokes Basic Sciences
Conclusions— MPIOs-αVCAM-1–enhanced imaging seems to be promising in the detection of individuals presenting with severe cerebrovascular responses after stroke, which could therefore benefit from anti-inflammatory treatments.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Gauberti, M., Montagne, A., Marcos-Contreras, O. A., Le Behot, A., Maubert, E., Vivien, D. Tags: Computerized tomography and Magnetic Resonance Imaging, Thrombolysis, Endothelium/vascular type/nitric oxide Basic Sciences Source Type: research

Statin Therapy Should be Discontinued in Patients With Intracerebral Hemorrhage Controversies in Stroke
Source: Stroke - June 24, 2013 Category: Neurology Authors: Goldstein, L. B. Tags: Secondary prevention, Acute Cerebral Hemorrhage Controversies in Stroke Source Type: research

Statin Therapy Should Not be Discontinued in Patients With Intracerebral Hemorrhage Controversies in Stroke
Source: Stroke - June 24, 2013 Category: Neurology Authors: Bustamante, A., Montaner, J. Tags: Acute Cerebral Hemorrhage, Cerebral Lacunes, Neuroprotectors, Other Stroke Treatment - Medical Controversies in Stroke Source Type: research

Continued Statin Treatment After Acute Intracranial Hemorrhage: Fighting Fire With Fire Controversies in Stroke
Source: Stroke - June 24, 2013 Category: Neurology Authors: Molina, C. A., Selim, M. H. Tags: Acute Cerebral Hemorrhage, Other Stroke Treatment - Medical Controversies in Stroke Source Type: research

Letter by Cappellari et al Regarding Article, "Statin Therapy and Outcome After Ischemic Stroke: Systematic Review and Meta-analysis of Observational Studies and Randomized Trials" Letter to the Editor
Source: Stroke - May 24, 2013 Category: Neurology Authors: Cappellari, M., Moretto, G., Bovi, P. Tags: Neuroprotectors, Thrombolysis Letter to the Editor Source Type: research

The Effect of Medical Treatments on Stroke Risk in Asymptomatic Carotid Stenosis Brief Reports
Conclusions— Antiplatelet therapy and blood pressure control are the most important factors in reducing short-term stroke and cardiovascular risk in patients with asymptomatic carotid stenosis. More prospective data are required for medical treatments in asymptomatic carotid stenosis in particular for current statin usage.
Source: Stroke - January 18, 2013 Category: Neurology Authors: King, A., Shipley, M., Markus, H., for the ACES Investigators Tags: Carotid Stenosis, Risk Factors for Stroke, Other Stroke Treatment - Medical Brief Reports Source Type: research

Statin Therapy and Outcome After Ischemic Stroke: Systematic Review and Meta-Analysis of Observational Studies and Randomized Trials Original Contributions
Conclusion— In the largest meta-analysis to date, statin therapy at stroke onset was associated with improved outcome, a finding not observed in studies restricted to thrombolysis-treated patients. Randomized trials of statin therapy in acute ischemic stroke are needed.
Source: Stroke - January 18, 2013 Category: Neurology Authors: Ni Chroinin, D., Asplund, K., Asberg, S., Callaly, E., Cuadrado-Godia, E., Diez-Tejedor, E., Di Napoli, M., Engelter, S. T., Furie, K. L., Giannopoulos, S., Gotto, A. M., Hannon, N., Jonsson, F., Kapral, M. K., Marti-Fabregas, J., Martinez-Sanchez, P., Mi Tags: Acute Cerebral Infarction, Neuroprotectors, Other Stroke Treatment - Medical Original Contributions Source Type: research

Adherence to Hospital Discharge Medication in Patients With Ischemic Stroke: A Prospective, Interventional 2-Phase Study Brief Reports
Conclusions— Providing detailed information on medication changes can lead to substantially improved adherence to discharge medication, probably resulting in better secondary stroke prevention.
Source: Stroke - January 18, 2013 Category: Neurology Authors: Hohmann, C., Neumann-Haefelin, T., Klotz, J. M., Freidank, A., Radziwill, R. Tags: Compliance/Adherence, Secondary prevention, Cerebrovascular disease/stroke, Anticoagulants, Antiplatelets Brief Reports Source Type: research