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Source: Stroke
Therapy: Statin Therapy

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Total 59 results found since Jan 2013.

No Relationship of Lipid-Lowering Agents to Hematoma Growth: Pooled Analysis of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials Studies Brief Reports
Conclusions— No independent associations were found between lipid-lowering medication and adverse outcomes in patients with intracerebral hemorrhage. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00226096 and NCT00716079.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Priglinger, M., Arima, H., Anderson, C., Krause, M., for the INTERACT Investigators Tags: Lipids, Cerebrovascular disease/stroke, Other Stroke Treatment - Medical Brief Reports Source Type: research

Progressive Cortical Neuronal Damage and Chronic Hemodynamic Impairment in Atherosclerotic Major Cerebral Artery Disease Clinical Sciences
Conclusions— In patients with atherosclerotic internal carotid artery or middle cerebral artery disease, the progression of cortical neuronal damage was associated with hemodynamic impairment at baseline and hemodynamic deterioration during follow-up. Statin use may be beneficial against hemodynamic deterioration and therefore neuroprotective.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Yamauchi, H., Kagawa, S., Kishibe, Y., Takahashi, M., Higashi, T. Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Clinical Sciences Source Type: research

Letter by Cappellari et al Regarding Article, "Statin Therapy and Outcome After Ischemic Stroke: Systematic Review and Meta-analysis of Observational Studies and Randomized Trials" Letter to the Editor
Source: Stroke - May 24, 2013 Category: Neurology Authors: Cappellari, M., Moretto, G., Bovi, P. Tags: Neuroprotectors, Thrombolysis Letter to the Editor Source Type: research

Association of Prestroke Statin Use and Lipid Levels With Outcome of Intracerebral Hemorrhage Brief Reports
Conclusions— Premorbid statin use did not affect the outcome of ICH, but lower low-density lipoprotein levels were associated with higher in-hospital mortality.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Mustanoja, S., Strbian, D., Putaala, J., Meretoja, A., Curtze, S., Haapaniemi, E., Sairanen, T., Hietikko, R., Siren, J., Kaste, M., Tatlisumak, T. Tags: Brief Reports Source Type: research

A Call for Rigorous Study of Statins in Resolution of Cerebral Cavernous Malformation Pathology Comments and Opinions
Source: Stroke - May 27, 2014 Category: Neurology Authors: Eisa-Beygi, S., Wen, X.-Y., Macdonald, R. L. Tags: Cerebrovascular disease/stroke, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Intracerebral Hemorrhage Comments and Opinions Source Type: research

Number of Cerebral Microbleeds and Risk of Intracerebral Hemorrhage After Intravenous Thrombolysis Clinical Sciences
Conclusions— Our findings indicate a higher risk of sICH and PH after intravenous thrombolysis when multiple CMBs are present, with a graded relationship to increasing baseline CMB number.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Dannenberg, S., Scheitz, J. F., Rozanski, M., Erdur, H., Brunecker, P., Werring, D. J., Fiebach, J. B., Nolte, C. H. Tags: Acute Cerebral Infarction, Intracerebral Hemorrhage, Thrombolysis Clinical Sciences Source Type: research

Racial/Ethnic Variation in Carotid Artery Revascularization Utilization and Outcomes: Analysis From the National Cardiovascular Data Registry Clinical Sciences
Conclusion— During the study period, utilization of CAS and CEA was highest among non-Hispanic whites. There was a trend toward increased CAS utilization over time among non-Hispanic whites and other groups, and a trend toward increased CEA utilization among Hispanics and blacks. In-hospital major adverse cardiac and cerebrovascular events remained comparable between groups, whereas 30-day major adverse cardiac and cerebrovascular events were significantly higher in blacks.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Wayangankar, S. A., Kennedy, K. F., Aronow, H. D., Rundback, J., Tafur, A., Drachman, D., Patel, B., Sivaram, C. A., Latif, F. Tags: Carotid Stenosis, Carotid endarterectomy, Angioplasty and Stenting Clinical Sciences Source Type: research

Do Patient Characteristics Explain the Differences in Outcome Between Medically Treated Patients in SAMMPRIS and WASID? Clinical Sciences
Conclusions— After adjustment for confounding baseline characteristics, WASID patients had an almost 2-fold higher risk of the SAMMPRIS primary end point, which supports the hypothesis that the lower rate of the primary end point in the medical arm of SAMMPRIS compared with WASID patients was as a result of the aggressive medical management used in SAMMPRIS. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00576693.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Chaturvedi, S., Turan, T. N., Lynn, M. J., Derdeyn, C. P., Fiorella, D., Janis, L. S., Chimowitz, M. I., for the SAMMPRIS Trial Investigators Tags: Risk Factors Clinical Sciences Source Type: research

Statin Treatment in Patients With Intracerebral Hemorrhage Comments and Opinions
Source: Stroke - December 22, 2017 Category: Neurology Authors: Matthias Endres, Christian H. Nolte, Jan F. Scheitz Tags: Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Comments and Opinions Source Type: research

Dynamic Permeability and Quantitative Susceptibility: Related Imaging Biomarkers in Cerebral Cavernous Malformations Brief Reports
Conclusions— The correlation between quantitative susceptibility mapping and dynamic contrast-enhanced quantitative perfusion suggests that the phenomena of permeability and iron deposition are related in CCM; hence, more leaky lesions also manifest a more cumulative iron burden. These techniques might be used as biomarkers to monitor the course of this disease and the effect of therapy.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Mikati, A. G., Tan, H., Shenkar, R., Li, L., Zhang, L., Guo, X., Larsson, H. B. W., Shi, C., Liu, T., Wang, Y., Shah, A., Edelman, R. R., Christoforidis, G., Awad, I. Tags: CT and MRI, Computerized tomography and Magnetic Resonance Imaging, Other imaging Brief Reports Source Type: research

Extravascular Optical Coherence Tomography: Evaluation of Carotid Atherosclerosis and Pravastatin Therapy Basic Sciences
Conclusions— OCT imaging offers the potential for real-time, detailed vessel lumen evaluation, potentially improving surgical accuracy and outcomes during cerebrovascular neurosurgical procedures. Pravastatin significantly increases vessel lumen patency in the ApoE–/– mouse on HFD.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Wicks, R. T., Huang, Y., Zhang, K., Zhao, M., Tyler, B. M., Suk, I., Hwang, L., Ruzevick, J., Jallo, G., Brem, H., Pradilla, G., Kang, J. U. Tags: Imaging, Coronary imaging: angiography/ultrasound/Doppler/CC, Other diagnostic testing, Computerized tomography and Magnetic Resonance Imaging Basic Sciences Source Type: research

High-Dose Simvastatin for Aneurysmal Subarachnoid Hemorrhage: Multicenter Randomized Controlled Double-Blinded Clinical Trial Clinical Sciences
Conclusions— High-dose simvastatin treatment should not be prescribed routinely for aneurysmal subarachnoid hemorrhage. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01077206.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Wong, G. K. C., Chan, D. Y. C., Siu, D. Y. W., Zee, B. C. Y., Poon, W. S., Chan, M. T. V., Gin, T., Leung, M., HDS-SAH Investigators, Zhu, Liang, Tan, Lee, Wong, Chan, Po, Woo, Chan Tags: Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Neuroprotectors Clinical Sciences Source Type: research

Use of Statins and Outcomes in Intracerebral Hemorrhage Patients Clinical Sciences
Conclusions—Although statin use, especially continued/new use, was associated with improved intracerebral hemorrhage outcomes, this effect may merely reflect the physician’s view of a patient’s prognosis rather than a predictor of survival.
Source: Stroke - July 24, 2017 Category: Neurology Authors: Fazeel M. Siddiqui, Carl D. Langefeld, Charles J. Moomaw, Mary E. Comeau, Padmini Sekar, Jonathan Rosand, Chelsea S. Kidwell, Sharyl Martini, Jennifer L. Osborne, Sonja Stutzman, Christiana Hall, Daniel Woo Tags: Intracranial Hemorrhage Original Contributions Source Type: research

Lipid-Lowering Agents and High HDL (High-Density Lipoprotein) Are Inversely Associated With Intracranial Aneurysm Rupture Clinical Sciences
Conclusions—Higher HDL values and the use of lipid-lowering agents are significantly inversely associated with ruptured intracranial aneurysms.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Anil Can, Victor M. Castro, Dmitriy Dligach, Sean Finan, Sheng Yu, Vivian Gainer, Nancy A. Shadick, Guergana Savova, Shawn Murphy, Tianxi Cai, Scott T. Weiss, Rose Du Tags: Risk Factors, Cerebral Aneurysm Original Contributions Source Type: research