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Source: Trends in Parasitology
Infectious Disease: Parasitic Diseases
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Total 534 results found since Jan 2013.
Sampling for malaria molecular surveillance
We present examples for different use cases, including detecting emergence and spread of rare variants, establishing transmission sources and inferring changes in malaria transmission intensity. This review will potentially guide the collection of samples and data, serve as a starting point for further methodological innovation, and enhance utilization of MMS to support malaria elimination.PMID:37730525 | DOI:10.1016/j.pt.2023.08.007
Source: Trends in Parasitology - September 20, 2023 Category: Parasitology Authors: Alfredo Mayor Deus S Ishengoma Joshua L Proctor Robert Verity Source Type: research
Light pollution may alter host-parasite interactions in aquatic ecosystems
Trends Parasitol. 2023 Sep 16:S1471-4922(23)00217-9. doi: 10.1016/j.pt.2023.08.013. Online ahead of print.ABSTRACTWith growing human populations living along freshwater shores and marine coastlines, aquatic ecosystems are experiencing rising levels of light pollution. Through its effects on hosts and parasites, anthropogenic light at night can disrupt host-parasite interactions evolved under a normal photoperiod. Yet its impact on aquatic parasites has been ignored to date. Here, I discuss the direct effects of light on the physiology and behaviour of parasite infective stages and their hosts. I argue that night-time light...
Source: Trends in Parasitology - September 18, 2023 Category: Parasitology Authors: Robert Poulin Source Type: research
Programming schistosomes - a crisper approach to transgenesis
This study outlines a promising strategy for functional genomics to study this parasite that causes a debilitating and neglected tropical disease.PMID:37718190 | DOI:10.1016/j.pt.2023.09.003
Source: Trends in Parasitology - September 17, 2023 Category: Parasitology Authors: Bernd H Kalinna Source Type: research
Critical interdependencies between Plasmodium nutrient flux and drugs
Trends Parasitol. 2023 Sep 14:S1471-4922(23)00212-X. doi: 10.1016/j.pt.2023.08.008. Online ahead of print.ABSTRACTNutrient import and waste efflux are critical dependencies for intracellular Plasmodium falciparum parasites. Nutrient transport proteins are often lineage specific and can provide unique targets for antimalarial drug development. P. falciparum nutrient transport pathways can be a double-edged sword for the parasite, not only mediating the import of nutrients and excretion of waste products but also providing an access route for drugs. Here we briefly summarise the nutrient acquisition pathways of intracellular...
Source: Trends in Parasitology - September 16, 2023 Category: Parasitology Authors: Isabelle G Henshall Tobias Spielmann Source Type: research
Trypanosomes as a magnifying glass for cell and molecular biology
Trends Parasitol. 2023 Sep 5:S1471-4922(23)00195-2. doi: 10.1016/j.pt.2023.08.004. Online ahead of print.ABSTRACTThe African trypanosome, Trypanosoma brucei, has developed into a flexible and robust experimental model for molecular and cellular parasitology, allowing us to better combat these and related parasites that cause worldwide suffering. Diminishing case numbers, due to efficient public health efforts, and recent development of new drug treatments have reduced the need for continued study of T. brucei in a disease context. However, we argue that this pathogen has been instrumental in revolutionary discoveries that ...
Source: Trends in Parasitology - September 7, 2023 Category: Parasitology Authors: Julius Luke š Dave Speijer Alena Z íková Juan D Alfonzo Hassan Hashimi Mark C Field Source Type: research
Biological implications of long-term anthelmintic treatment: what else besides resistance are we selecting for?
Trends Parasitol. 2023 Aug 24:S1471-4922(23)00193-9. doi: 10.1016/j.pt.2023.08.002. Online ahead of print.ABSTRACTLong-term intensive use of anthelmintics for parasite control of livestock, companion animals, and humans has resulted in widespread anthelmintic resistance, a problem of great socioeconomic significance. But anthelmintic therapy may also select for other biological traits, which could have implications for anthelmintic performance. Here, we highlight recent examples of changing parasite dynamics following anthelmintic administration, which do not fit the definition of anthelmintic resistance. We also consider ...
Source: Trends in Parasitology - August 26, 2023 Category: Parasitology Authors: Martin K Nielsen Ray M Kaplan Ghazanfar Abbas Abdul Jabbar Source Type: research
Monocytes as primary defenders against Toxoplasma gondii infection
Trends Parasitol. 2023 Aug 24:S1471-4922(23)00187-3. doi: 10.1016/j.pt.2023.07.007. Online ahead of print.ABSTRACTMonocytes are recruited from the bone marrow to sites of infection where they release cytokines and chemokines, function in antimicrobial immunity, and differentiate into macrophages and dendritic cells to control infection. Although many studies have focused on monocyte-derived macrophages and dendritic cells, recent work has examined the unique roles of monocytes during infection to promote immune defense. We focus on the effector functions of monocytes during infection with the parasite Toxoplasma gondii, an...
Source: Trends in Parasitology - August 26, 2023 Category: Parasitology Authors: Stephanie B Orchanian Melissa B Lodoen Source Type: research
Biological implications of long-term anthelmintic treatment: what else besides resistance are we selecting for?
Trends Parasitol. 2023 Aug 24:S1471-4922(23)00193-9. doi: 10.1016/j.pt.2023.08.002. Online ahead of print.ABSTRACTLong-term intensive use of anthelmintics for parasite control of livestock, companion animals, and humans has resulted in widespread anthelmintic resistance, a problem of great socioeconomic significance. But anthelmintic therapy may also select for other biological traits, which could have implications for anthelmintic performance. Here, we highlight recent examples of changing parasite dynamics following anthelmintic administration, which do not fit the definition of anthelmintic resistance. We also consider ...
Source: Trends in Parasitology - August 26, 2023 Category: Parasitology Authors: Martin K Nielsen Ray M Kaplan Ghazanfar Abbas Abdul Jabbar Source Type: research
Monocytes as primary defenders against Toxoplasma gondii infection
Trends Parasitol. 2023 Aug 24:S1471-4922(23)00187-3. doi: 10.1016/j.pt.2023.07.007. Online ahead of print.ABSTRACTMonocytes are recruited from the bone marrow to sites of infection where they release cytokines and chemokines, function in antimicrobial immunity, and differentiate into macrophages and dendritic cells to control infection. Although many studies have focused on monocyte-derived macrophages and dendritic cells, recent work has examined the unique roles of monocytes during infection to promote immune defense. We focus on the effector functions of monocytes during infection with the parasite Toxoplasma gondii, an...
Source: Trends in Parasitology - August 26, 2023 Category: Parasitology Authors: Stephanie B Orchanian Melissa B Lodoen Source Type: research
Biological implications of long-term anthelmintic treatment: what else besides resistance are we selecting for?
Trends Parasitol. 2023 Aug 24:S1471-4922(23)00193-9. doi: 10.1016/j.pt.2023.08.002. Online ahead of print.ABSTRACTLong-term intensive use of anthelmintics for parasite control of livestock, companion animals, and humans has resulted in widespread anthelmintic resistance, a problem of great socioeconomic significance. But anthelmintic therapy may also select for other biological traits, which could have implications for anthelmintic performance. Here, we highlight recent examples of changing parasite dynamics following anthelmintic administration, which do not fit the definition of anthelmintic resistance. We also consider ...
Source: Trends in Parasitology - August 26, 2023 Category: Parasitology Authors: Martin K Nielsen Ray M Kaplan Ghazanfar Abbas Abdul Jabbar Source Type: research
Monocytes as primary defenders against Toxoplasma gondii infection
Trends Parasitol. 2023 Aug 24:S1471-4922(23)00187-3. doi: 10.1016/j.pt.2023.07.007. Online ahead of print.ABSTRACTMonocytes are recruited from the bone marrow to sites of infection where they release cytokines and chemokines, function in antimicrobial immunity, and differentiate into macrophages and dendritic cells to control infection. Although many studies have focused on monocyte-derived macrophages and dendritic cells, recent work has examined the unique roles of monocytes during infection to promote immune defense. We focus on the effector functions of monocytes during infection with the parasite Toxoplasma gondii, an...
Source: Trends in Parasitology - August 26, 2023 Category: Parasitology Authors: Stephanie B Orchanian Melissa B Lodoen Source Type: research
