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Source: Toxicon

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Total 24 results found since Jan 2013.

Early versus late injections of Botulinumtoxin type A in post-stroke spastic movement disorder: A literature review
Toxicon. 2023 May 3:107150. doi: 10.1016/j.toxicon.2023.107150. Online ahead of print.ABSTRACTPost-stroke spastic movement disorder (PS-SMD) is one of the main causes of severe disability in the chronic phase after stroke. The prevalence of SMD rises up with time after stroke to more than 28% in the chronic phase, and its secondary complications such as contracture, abnormal postures and/or movement patterns, spasticity-associated pain, also increases with time after stroke when physical and medical management of PS-SMD had been delayed in the early stroke phase. It has been published by several controlled studies that the...
Source: Toxicon - May 5, 2023 Category: Toxicology Authors: J örg Wissel Songjin Ri Anatol Kivi Source Type: research

Heart Rate Variability modifications induced by high doses of IncobotulinumtoxinA and OnabotulinumtoxinA in hemiplegic chronic stroke patients: A single blind randomized controlled, crossover pilot study.
CONCLUSIONS: Our data show that high doses (>600 U) of incobotulinumtoxinA and onabotulinumtoxinA do not influence the cardiovascular activity of the autonomic nervous system in chronic hemiplegic spastic stroke survivors. PMID: 28877510 [PubMed - as supplied by publisher]
Source: Toxicon - September 3, 2017 Category: Toxicology Authors: Baricich A, Grana E, Carda S, Santamato A, Molinari C, Cisari C, Invernizzi M Tags: Toxicon Source Type: research

Do gait parameters improve after botulinum toxin injections in post stroke patients? A prospective study
In conclusion the use of botulinum toxin injections is beneficial in post stroke patients as this is depicted in gait parameters change which accompanies the spasticity reduction.PMID:34384786 | DOI:10.1016/j.toxicon.2021.08.001
Source: Toxicon - August 13, 2021 Category: Toxicology Authors: Dimitrios N Varvarousis Dimitris Dimopoulos George I Vasileiadis Ioannis Manolis Avraam Ploumis Source Type: research

Functional outcomes following ultrasound-guided botulinum toxin type A injections to reduce spastic equinovarus in adult post-stroke patients.
CONCLUSION: Spastic equinovarus deformity observed in patients after stroke creates significant limitations in the patient's functional walking speed and distance. As a result, when BoNT-A injections accompanied by ultrasound to improve equinovarus deformity considering the innervation zones of the muscles with a specific approach are administered directly into the muscle at the correct point, we can say it provides hopeful results from a functional point of view. PMID: 29530514 [PubMed - as supplied by publisher]
Source: Toxicon - March 9, 2018 Category: Toxicology Authors: Aktürk S, Büyükavcı R, Ersoy Y Tags: Toxicon Source Type: research

The effectiveness of botulinum toxin on spasticity and gait of hemiplegic patients after stroke: a systematic review and meta-analysis
This study included: randomized controlled trials (RCTs), non-randomized or controlled clinical trials (CCTs) or cluster trials, clinical trials of various phases (I-III), interrupted time series (ITS) studies with at least three data points before and after the intervention, controlled before and after (CBA) studies, prospective and retrospective comparative cohort studies, case-control and multicentred studies. The patients included in these studies had similar characteristics: age over 18 years, history of stroke and following hemiplegia, minimum modified Ashworth scale (MAS) score of 2 and duration since stroke over 6 ...
Source: Toxicon - October 9, 2021 Category: Toxicology Authors: Dimitrios Varvarousis Christina Martzivanou Dimitris Dimopoulos Georgios Dimakopoulos George I Vasileiadis Avraam Ploumis Source Type: research

The effectiveness of botulinum toxin on spasticity and gait of hemiplegic patients after stroke: A systematic review and meta-analysis
This study included: randomized controlled trials (RCTs), non-randomized or controlled clinical trials (CCTs) or cluster trials, clinical trials of various phases (I-III), interrupted time series (ITS) studies with at least three data points before and after the intervention, controlled before and after (CBA) studies, prospective and retrospective comparative cohort studies, case-control and multicentred studies. The patients included in these studies had similar characteristics: age over 18 years, history of stroke and following hemiplegia, minimum modified Ashworth scale (MAS) score of 2 and duration since stroke over 6 ...
Source: Toxicon - October 9, 2021 Category: Toxicology Authors: Dimitrios N Varvarousis Christina Martzivanou Dimitris Dimopoulos Georgios Dimakopoulos George I Vasileiadis Avraam Ploumis Source Type: research

Fatal stroke after Bothrops snakebite in the Amazonas state, Brazil: A case report.
Abstract Bothrops atrox is the snake responsible for the majority of snakebites in the Brazilian Amazon. Patients generally evolve to local manifestations such as edema, pain and ecchymoses. Systemic effects of B. atrox venom are usually restricted to blood incoagulability and spontaneous bleeding. However, in a few cases, bleeding in the central nervous system may occur, which can lead to sequels and deaths. Here, we report a case of a 59 year-old woman who presented edema, pain and ecchymoses on the right foot, headache, nausea, diarrhea, hypertension and blood incoagulability after the bite by Bothrops snake in...
Source: Toxicon - August 22, 2017 Category: Toxicology Authors: Silva de Oliveira S, Freitas-de-Sousa LA, Alves EC, de Lima Ferreira LC, da Silva IM, de Lacerda MVG, Fan HW, Mourada-Silva AM, Monteiro WM Tags: Toxicon Source Type: research

Brainstem ischemic stroke after to Bothrops atrox snakebite.
We report case of a 48 years old woman bitten on her right foot by a Bothrops atrox viper. As a result, she developed a severe coagulopathy which improved with application of polyvalent antivenom. Four days after bite she suffered a devastating brainstem ischemic stroke. Possible pathogenetic mechanisms are discussed. PMID: 27527269 [PubMed - as supplied by publisher]
Source: Toxicon - August 11, 2016 Category: Toxicology Authors: Cañas CA Tags: Toxicon Source Type: research

Hemorrhagic stroke secondary to Bothrops spp. venom: A case report.
Abstract The Bothrops spp. venom contain metalloproteinases that contributes to vascular and hemorrhagic effects. This case report describes a 58 years-old patient from the city of Dona Inês, Paraiba, Brazil victim of an ophidian accident by Bothrops spp. The vascular and hemorrhagic effects of venom components have triggered a hemorrhagic stroke. Brazil has about 600 deaths annually due to ophidian accidents. However, as reports have been precarious, the obtaining of epidemiological-clinical data has been affected. This case highlights the importance of prior knowledge of possible neurological and vascular compl...
Source: Toxicon - April 1, 2017 Category: Toxicology Authors: Delgado AB, Vaz Lacet Gondim CC, Reichert LP, da Silva PH, da Costa E Souza RM, de Paiva Fernandes TM, Calvo BF Tags: Toxicon Source Type: research