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Source: Thrombosis Research
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Total 221 results found since Jan 2013.
Air pollution impacts on in-hospital case-fatality rate of ischemic stroke patients
A growing body of evidence suggests that air pollution exposure is associated with an increased risk for cardiovascular diseases. Data regarding the impact of long-term air pollution exposure on ischemic stroke mortality are sparse.
Source: Thrombosis Research - March 22, 2023 Category: Hematology Authors: Karsten Keller, Seyed Hamed Rastguye Haghi, Omar Hahad, Irene Schmidtmann, Sourangsu Chowdhury, Jos Lelieveld, Thomas M ünzel, Lukas Hobohm Source Type: research
Predicting functional outcomes after acute ischemic stroke – Is thrombelastography useful outside perioperative bleeding management?
We read with great interest the recent publication by Ryu et al., on the utility of thrombelastography (TEG) as a prognosticator of functional outcomes after ischemic stroke among patients that underwent endovascular treatment (EVT) [1]. The authors suggested that a hypercoagulable signal on TEG, being a reaction time
Source: Thrombosis Research - May 12, 2023 Category: Hematology Authors: Amir Butt, Anna Miller, Kenichi Tanaka, Kenneth Stewart Tags: Letter to the Editors-in-Chief Source Type: research
Inverse association between serum lipoprotein(a) and cerebral hemorrhage in the Japanese population
This study investigated the association between Lp(a) and the incidence of stroke and/or its subtypes in the general Japanese population.Materials and Methods: This population-based prospective cohort study included 10,494 community-dwelling participants (4,030 males/6,464 females). The incidence of stroke and its subtypes was the primary outcome. The subjects were divided into tertiles based on their Lp(a) levels, and the risk of all stroke and stroke subtypes was examined using Cox's proportional hazard model.Results: A total of 393 subjects (199 males and 194 females) with stroke were identified during a follow-up durat...
Source: Thrombosis Research - December 26, 2012 Category: Hematology Authors: Shizukiyo Ishikawa, Kazuhiko Kotani, Kazuomi Kario, Kazunori Kayaba, Tadao Gotoh, Yosikazu Nakamura, Eiji Kajii, the Jichi Medical School (JMS) cohort study group Tags: Clinical Studies Source Type: research
Comparing patient-level and site-level anticoagulation control as predictors of adverse events
Conclusion: iTTR significantly predicted risk of major hemorrhage, ischemic stroke, and all-cause mortality. cTTR was a weak predictor of all-cause mortality. Though cTTR may be a better target for site-level quality improvement efforts, iTTR may be a more suitable measure for use in comparative effectiveness research.
Source: Thrombosis Research - February 6, 2014 Category: Hematology Authors: Ramon S. Cancino, Elaine M. Hylek, Joel I. Reisman, Adam J. Rose Tags: Coagulation and Fibrinolysis Source Type: research
Anticoagulation management in patients with mechanical heart valves having pacemaker or defibrillator insertion
Conclusion: We found a low risk for stroke in the absence of postoperative bridging. For patients with device replacement surgery reversal of the anticoagulant effect at the time of procedure might reduce the risk for pocket hematoma, but this requires prospective evaluation including the risk of thromboembolism.
Source: Thrombosis Research - January 31, 2013 Category: Hematology Authors: S. Schulman, J. Schoenberg, S. Divakara Menon, A.C. Spyropoulos, J.S. Healey, J.W. Eikelboom Tags: Clinical Studies Source Type: research
Prasugrel reduces ischaemic infarct volume and ameliorates neurological deficits in a non-human primate model of middle cerebral artery thrombosis
Several clinical trials have demonstrated the benefits of thienopyridine monotherapy in ischaemic stroke patients. Non-human primate models of ischaemic stroke have been used for various antithrombotic agents; however, to the best of our knowledge, there is no data on the effects of P2Y12 antagonists in models, such as the thrombotic middle cerebral artery occlusion (MCAO) monkey model. Accordingly, it remains unclear what level of inhibition of platelet aggregation (IPA) is required for optimal treatment of ischaemic stroke.
Source: Thrombosis Research - September 11, 2015 Category: Hematology Authors: Atsuyuki Tomizawa, Kousaku Ohno, Joseph A. Jakubowski, Makoto Mizuno, Atsuhiro Sugidachi Source Type: research
Association between fibrinogen and fibrinogen γ’ and atherosclerotic plaque morphology and composition in symptomatic carotid artery stenosis: Plaque-At-RISK study
Von Willebrand Factor (VWF), ADAMTS13, fibrinogen and fibrinogen γ’ are associated with an increased risk of ischemic stroke. Carotid atherosclerosis is an important risk factor for ischemic stroke. Characteristics of the vulnerable plaque; intraplaque hemorrhage (IPH), plaque ulceration and lipid-rich necrotic core (LRNC) can be visualized with imaging techni ques. Since atherosclerosis might attribute to the association between coagulation factors and ischemic stroke risk, the aim of this study is to investigate the association between coagulation factors and atherosclerotic plaque characteristics in more detail.
Source: Thrombosis Research - February 27, 2019 Category: Hematology Authors: A.C. van Dijk, S.J. Donkel, T. Zadi, M.A.H. Sonneveld, F.H.B.M. Schreuder, M.F. Chohan, P.J. Koudstaal, F.W.G. Leebeek, R. Saxena, J. Hendrikse, M.E. Kooi, A. van der Lugt, M.P.M. de Maat Tags: Full Length Article Source Type: research
Ensuring medication adherence with direct oral anticoagulant drugs: Lessons from adherence with vitamin K antagonists (VKAs)
Abstract: Medication adherence (taking drugs properly) is uncommon among patients on warfarin. Poor adherence to warfarin leads to an increase in adverse medical events, including stroke in atrial fibrillation (AF). Factors related to patients, physicians and the health system account for poor adherence. Direct oral anticoagulants (DOACs) are easier to use than warfarin, with fewer drug and food interactions and no need for routine blood monitoring. A proper use of DOACs may reduce the risk of stroke in AF. However, in clinical settings where no laboratory monitoring is needed, a poor medication adherence is common and may...
Source: Thrombosis Research - February 12, 2014 Category: Hematology Authors: Alessandro Di Minno, Gaia Spadarella, Antonella Tufano, Domenico Prisco, Giovanni Di Minno Tags: Mini-Reviews Source Type: research
New Method of Thrombus Preparation Using a Fluid Model for Evaluation of Thrombectomy Devices in a Swine Model
The objective of this study was to explore a new method of thrombus preparation with fluid model (FM) for assessment of thrombectomy devices used in the recanalization of acute ischemic stroke.
Source: Thrombosis Research - August 22, 2014 Category: Hematology Authors: Qiuji Shao, Liangfu Zhu, Tianxiao Li, Li Li, Dujuan Li, Jiaqiang Zhang, Wei Ren, Liheng Wu Source Type: research
Thrombosis: A major contributor to global disease burden
Thrombosis is a common pathology underlying ischemic heart disease, ischemic stroke, and venous thromboembolism (VTE). The Global Burden of Disease Study 2010 (GBD 2010) documented that ischemic heart disease and stroke collectively caused one in four deaths worldwide. GBD 2010 did not report data for VTE as a cause of death and disability. We performed a systematic review of the literature on the global disease burden due to VTE in low, middle and high income countries. Studies from Western Europe, North America, Australia, and Southern Latin America (Argentina) yielded consistent results with annual incidences ranging fr...
Source: Thrombosis Research - October 10, 2014 Category: Hematology Authors: ISTH Steering Committee for World Thrombosis Day Tags: Review Article Source Type: research
Apixaban exerts anti-inflammatory effects in mesangial cells by blocking thrombin/protease-activated receptor-1 system
Atrial fibrillation (AF) is most frequent arrhythmia in patients with chronic kidney disease (CKD) [1,2]. Since diabetes and hypertension are risk components of CHADS2 score and also risk factors for CKD, CKD could affect cardiovascular outcomes in patients with AF [2–5]. Indeed, several papers have shown that renal dysfunction increases the risk of thromboembolic events, stroke and all-cause mortality in AF patients [2–5]. In randomized trials of AF patients with stage III CKD, novel oral anticoagulant, dabigatran 150mg twice daily was superior to warfarin for stroke prevention, while apixaban was superior in regard t...
Source: Thrombosis Research - September 25, 2014 Category: Hematology Authors: Yuji Ishibashi, Takanori Matsui, Sho-ichi Yamagishi Tags: Letter to the Editor-in-Chief Source Type: research
New method of thrombus preparation using a fluid model for evaluation of thrombectomy devices in a swine model
The objective of this study was to explore a new method of thrombus preparation with fluid model (FM) for assessment of thrombectomy devices used in the recanalization of acute ischemic stroke.
Source: Thrombosis Research - August 22, 2014 Category: Hematology Authors: Qiuji Shao, Liangfu Zhu, Tianxiao Li, Li Li, Dujuan Li, Jiaqiang Zhang, Wei Ren, Liheng Wu Tags: Regular Article Source Type: research
Venous thrombosis and risk of cancer in patients with arterial cardiovascular disease
We examined the association between venous thromboembolism and cancer in patients with acute myocardial infarction or stroke.
Source: Thrombosis Research - November 13, 2014 Category: Hematology Authors: Sigrun Alba Johannesdottir Schmidt, Dóra Körmendiné Farkas, Lars Pedersen, Paolo Prandoni, Henrik Toft Sørensen Source Type: research
Elevated Circulating VE-Cadherin+CD144+Endothelial Microparticles in Ischemic Cerebrovascular Disease
Circulating endothelial microparticles act as biological markers of endothelial function that reflect vascular injury. Here, we examined the hypothesis that the quantity of endothelial microparticles in the circulation is increased in patients with ischemic cerebrovascular diseases, and investigated the potential utility of various phenotypes of endothelial microparticles as specific biomarkers of endothelial cell dysfunction. We additionally focused on identifying endothelial microparticles that may be effectively utilized as biomarkers of stroke severity in acute ischemic stroke patients.
Source: Thrombosis Research - December 5, 2014 Category: Hematology Authors: Pingping Li, Chao Qin Tags: Regular Article Source Type: research
An optimum prophylactic dose of prasugrel monotherapy may safely and effectively prevent the development of experimental thrombotic strokes
Myocardial infarction and stroke are two of the leading causes of death and disability worldwide [1,2]. Using a combination of aspirin and a platelet P2Y12 antagonist, several large clinical trials have definitively demonstrated the efficacy of dual antiplatelet therapies in preventing myocardial infarction, stroke or death in patients with acute coronary syndromes [3–8]. Dual antiplatelet therapy with aspirin and a thienopyridine-based P2Y12 antagonist (clopidogrel or prasugrel) has now become the standard of care of patients with acute coronary syndromes.
Source: Thrombosis Research - October 16, 2015 Category: Hematology Authors: Frederick A. Ofosu Source Type: research
