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Increased prevalence of VTE reported by Klok and colleagues, the numbers don't add up
In this study the authors report that 31% of patients met the composite outcome of having a thrombotic complication which they define as having a pulmonary embolism, deep vein thrombosis, or an ischemic stroke. The study included 184 patients with 31 patients having a thrombotic complication. This adds up to an incidence of 16.8%, not 31%.
Source: Thrombosis Research - April 25, 2020 Category: Hematology Authors: Yonatan Y. Greenstein Tags: Letter to the Editors-in-Chief Source Type: research

Increased rates of hand ischemia following arterial cannulation in patients with severe COVID19-related pneumonia
Thrombotic complications in patients with COVID19 infection are increasingly reported due to the hypercoagulable state induced by the disease [1 –3]. In particular, arterial thromboembolism has been described in up to 4% of patients, with ischemic stroke being the most common thrombotic event [2]. While catheter-related upper extremity venous thromboses are anecdotally reported [4,5], at the moment no reports are available regarding upper extremity arterial thrombosis following cannulation.
Source: Thrombosis Research - June 14, 2020 Category: Hematology Authors: Walter Dorigo, Aaron Fargion, Laura Paperetti, Roberto Falso, Manuela Bonizzoli, Paolo Fontanari, Loredana Poggesi, Carlo Pratesi Tags: Letter to the Editors-in-Chief Source Type: research

Thromboembolic events related to atrial fibrillation during the COVID-19 epidemic in Denmark
The COVID-19 epidemic has threatened to overwhelm the health-care systems of European countries resulting in government decisions of extensive societal lockdowns. There have been considerable concerns regarding the collateral effects of the COVID-19 epidemic overshadowing the care of patients with other medical conditions including cardiovascular diseases. Of interest, decreases in the registered incidences of atrial fibrillation (AF) and ischemic stroke have been reported [1,2]. AF is a common reason for physician contact and AF patients are often recommended treatment with oral anticoagulants to mitigate the associated r...
Source: Thrombosis Research - July 29, 2020 Category: Hematology Authors: Peter Vibe Rasmussen, Paul Blanche, Jarl Emanuel Strange, Jawad Haider Butt, Frederik Dalgaard, Kristian Kragholm, Matthew Phelps, Gunnar Gislason, Morten Lock Hansen Tags: Letter to the Editors-in-Chief Source Type: research

Heparin-induced thrombocytopenia and thrombosis in a patient with Covid-19
Covid-19 has significant implications of hematologic systems, including lymphocytopenia, thrombocytopenia, ischemic or hemorrhagic stroke, pulmonary thromboembolism, and myocardial infarction [1,2]. Iwasaki et al. reported that the pathogen of Covid-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can induce immune dysfunction, inflammation, and antibody-dependent enhancement by activating host cells via the Fc γIIa receptor in the same way as SARS-CoV-1 [3].
Source: Thrombosis Research - August 2, 2020 Category: Hematology Authors: Ching-Tai Huang, Shao-Yun Hsu, Ko-Wei Chang, Chung-Guei Huang, Cheng-Ta Yang, Ming-Huei Cheng Tags: Letter to the Editors-in-Chief Source Type: research

COVID-19 versus HIT hypercoagulability
A striking feature of COVID-19 is the high frequency of thrombosis, particularly in patients who require admission to intensive care unit because of respiratory complications (pneumonia/adult respiratory distress syndrome). The spectrum of thrombotic events is wide, including in situ pulmonary thrombosis, deep-vein thrombosis and associated pulmonary embolism, as well as arterial thrombotic events (stroke, myocardial infarction, limb artery thrombosis). Unusual thrombotic events have also been reported, e.g., cerebral venous sinus thrombosis, mesenteric artery and vein thrombosis.
Source: Thrombosis Research - August 8, 2020 Category: Hematology Authors: Theodore E. Warkentin, Scott Kaatz Tags: Review Article Source Type: research

The effect of race on composite thrombotic events in patients with COVID-19
COVID-19 associated coagulopathy and mortality related to thrombotic complications have been suggested as biological mediators in racial disparities related to COVID-19. We studied the adjusted prevalence of acute ischemic stroke, pulmonary embolism, myocardial infarction, and deep venous thrombosis stratified by race in hospitalized patients in one New York City borough during the local COVID-19 surge. The multi-racial cohort included 4,299 patients hospitalized with COVID-19, 9% of whom were white, 40% black, 41% Hispanic and 10% Asian or other.
Source: Thrombosis Research - December 21, 2020 Category: Hematology Authors: Charles Esenwa, Santiago R. Unda, David J. Altschul, Nikunj K. Patel, Avinash Malaviya, Johanna Seiden, Andrea Lendaris, Khadean Moncrieffe, Daniel L. Labovitz Tags: Letter to the Editors-in-Chief Source Type: research

Warfarin anticoagulation in the Covid-19 pandemic: Telephone-based management at a regional hematology outpatient center in Joinville, Brazil
Oral anticoagulation (OA) is a well-established therapeutic approach for prevention of cardioembolic stroke and venous thromboembolism [1]. Adequate OA is a key element in reducing the high social burden, morbidity and mortality associated with cardiovascular diseases [2 –4]. In January 2020, the World Health Organization (WHO) declared COVID-19 a public health emergency of international concern. Since then, the strategy of social distancing has been adopted in most countries, with varying degrees of restriction and compliance.
Source: Thrombosis Research - July 9, 2021 Category: Hematology Authors: Kendra Lys Calixto Machado, Suzana Tanquella da Rosa, Soraya Dobner, Ivan Schneider Boettcher, Gilberto Comaru Pasqualotto, Adelina Elisabeth Lehmkuhl Lopes, Tain á de Araújo, Lysandra Patricia Luchtenberg Bolduan, Maria Daniela Holthausen Perico Colomb Tags: Letter to the Editors-in-Chief Source Type: research

The long haul COVID-19 arterial thrombosis
The presence of a coexisting hypercoagulable state associated with Covid-19 infection has gained attention and several studies have already described acute limb ischemia (ALI) and peripheral arterial disease in critically ill patients, as well as coronary artery disease and ischemic stroke as manifestations usually associated with respiratory distress. Actually no information is currently available on how long inflammation and thrombotic derangements can last after recovery from Covid-19 symptoms and which patients are prone to develop acute arterial thrombosis.
Source: Thrombosis Research - July 26, 2022 Category: Hematology Authors: Maria Pia Borrelli, Adelaide Buora, Paolo Frigatti Tags: Letter to the Editors-in-Chief Source Type: research