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Mechanisms of Stroke in Patients with Chronic Kidney Disease.
Abstract BACKGROUND: Given the increasing worldwide prevalence of chronic kidney disease (CKD), it is critical to decrease the associated risk of debilitating vascular complications, including stroke, congestive heart failure, myocardial infarction, and peripheral vascular disease. Treatment options for reducing the risk of all subtypes of stroke in patients with CKD remain limited. For patients with end-stage kidney disease (ESKD), novel applications of noninvasive imaging may help personalize the type of dialysis and dialysis prescription for patients at high-risk. SUMMARY: This manuscript reviews the heigh...
Source: American Journal of Nephrology - August 27, 2019 Category: Urology & Nephrology Authors: Ghoshal S, Freedman BI Tags: Am J Nephrol Source Type: research

Association of Dyskalemias with Ischemic Stroke in Advanced Chronic Kidney Disease Patients Transitioning to Dialysis
CONCLUSION: In patients with advanced CKD, hypokalemia (chronic exposure) was associated with a higher risk of ischemic stroke, whereas hyperkalemia (acute exposure) was associated with a lower risk of ischemic stroke. Further studies in this population are needed to explore the mechanisms underlying these associations.PMID:34289468 | DOI:10.1159/000516902
Source: American Journal of Nephrology - July 21, 2021 Category: Urology & Nephrology Authors: Ankur A Dashputre Keiichi Sumida Fridtjof Thomas Justin Gatwood Oguz Akbilgic Praveen K Potukuchi Yoshitsugu Obi Miklos Z Molnar Elani Streja Kamyar Kalantar Zadeh Csaba P Kovesdy Source Type: research

Patients' Characteristics Affect the Survival Benefit of Warfarin Treatment for Hemodialysis Patients with Atrial Fibrillation. A Historical Cohort Study.
CONCLUSION: VKA may provide an early survival benefit; however, this is partially offset later during the follow-up. In addition, heterogeneous risk-benefit profiles were observed among subgroups of dialysis-dependent patients with AF, further emphasizing the complexities of tailoring stroke prevention strategies in this population. PMID: 27598317 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - September 6, 2016 Category: Urology & Nephrology Authors: Brancaccio D, Neri L, Bellocchio F, Barbieri C, Amato C, Mari F, Canaud B, Stuard S Tags: Am J Nephrol Source Type: research

Cognitive Impairment in Advanced Chronic Kidney Disease: The Canadian Frailty Observation and Interventions Trial.
CONCLUSIONS: Our study uncovered a high rate of unrecognized cognitive impairment in an advanced CKD population. This impairment is global, affecting all aspects of cognition and is likely vascular in nature. The longitudinal trajectory of cognitive function and its effect on dialysis decision-making and outcomes deserves further study. PMID: 27798938 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - October 31, 2016 Category: Urology & Nephrology Authors: Foster R, Walker S, Brar R, Hiebert B, Komenda P, Rigatto C, Storsley L, Prasad B, Bohm C, Tangri N Tags: Am J Nephrol Source Type: research

Cause-Specific Mortality in Patients with Chronic Kidney Disease and Atrial Fibrillation.
CONCLUSIONS: In a non-dialysis-dependent CKD population, the presence of AF was associated with higher all-cause and cardiovascular mortality. These data suggest that patients with both CKD and AF are at high cardiovascular risk, and thus clinical practice (or trials) should aim at reducing the overall excess cardiovascular mortality (not stroke alone) in patients with AF and CKD. PMID: 30048961 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - July 26, 2018 Category: Urology & Nephrology Authors: Airy M, Schold JD, Jolly SE, Arrigain S, Bansal N, Winkelmayer WC, Nally JV, Navaneethan SD Tags: Am J Nephrol Source Type: research

Readmissions after Acute Kidney Injury during Left Ventricular Assist Device Implantation Hospitalization.
CONCLUSION: AKI-D was associated with highest -30-day readmission risk, possibly related to negatively synergistic effects of LVAD, kidney dysfunction, and dialysis related factors on infection and GI bleeding risks. AKI alone was not associated with increased readmission risk. PMID: 31962311 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - January 20, 2020 Category: Urology & Nephrology Authors: Walther CP, Winkelmayer WC, Deswal A, Niu J, Navaneethan SD Tags: Am J Nephrol Source Type: research

Association of Cognitive Function Screening Results with Adherence and Performance in a Pedometer-Based Intervention
CONCLUSION: Participants with worse results on cognitive function screening had worse adherence and derived less benefit from this pedometer-based intervention. Future exercise interventions should be developed incorporating methods to address cognitive impairment, for example, by including caregivers when planning such interventions.PMID:33979802 | DOI:10.1159/000516130
Source: American Journal of Nephrology - May 12, 2021 Category: Urology & Nephrology Authors: Anoop Sheshadri Piyawan Kittiskulnam Cynthia Delgado Rebecca L Sudore Jennifer C Lai Kirsten L Johansen Source Type: research

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