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Warfarin dosing strategies evolution and its progress in the era of precision medicine, a narrative review
Conclusions Looking at the big picture, the use of genetic dosing for warfarin initiation can lead to better outcomes. Whether these better outcomes are clinically or economically beneficial remains controversial.
Source: International Journal of Clinical Pharmacy - March 5, 2022 Category: Drugs & Pharmacology Source Type: research

Evaluation of rivaroxaban-, apixaban- and dabigatran-associated hemorrhagic events using the FDA-Adverse event reporting system (FAERS) database
Conclusions Overall, we found a moderate signal of higher frequency of reporting hemorrhage in rivaroxban compared with dabigatran and decreased hemorrhagic event reporting in apixaban compared with dabigatran. While this potential signal has not been confirmed in clinical trials or observational studies, in clinical practice, attention should be paid to the risk of potential hemorrhage when the patients switch from apixaban to dabigatran or rivaroxban.
Source: International Journal of Clinical Pharmacy - December 1, 2021 Category: Drugs & Pharmacology Source Type: research

A clinical audit of oral anticoagulant therapy in aged care residents with atrial fibrillation
Conclusion Many residents with non-valvular AF and significant risk of stroke were not receiving oral anticoagulation despite a lack of documented reason for non-prescribing. Non-vitamin K antagonists were widely prescribed but dosing of these agents could still be improved. There remains a need to improve anticoagulant prescribing for aged care residents and optimise stroke prevention in this population.
Source: International Journal of Clinical Pharmacy - April 13, 2020 Category: Drugs & Pharmacology Source Type: research

Mortality risk in atrial fibrillation: the role  of aspirin, vitamin K and non-vitamin K antagonists
Conclusion Non vitamin K oral anticoagulants are   associated with a higher risk on all-cause mortality, particularly in men and in patients with higher stroke risk.
Source: International Journal of Clinical Pharmacy - October 7, 2019 Category: Drugs & Pharmacology Source Type: research

Utilization of oral anticoagulants in Korean nonvalvular atrial fibrillation patients
Conclusions The presence of comorbidities was linked to NOAC use over vitamin K antagonist, which is different from prescription factor studies in other countries and requires further study.
Source: International Journal of Clinical Pharmacy - September 13, 2019 Category: Drugs & Pharmacology Source Type: research

How prepared are pharmacists to support atrial fibrillation patients in adhering to newly prescribed oral anticoagulants?
Conclusion Results suggest the provision of NMS for NOACs is low. Supporting pharmacists with tailored education and adherence support might foster dissemination.
Source: International Journal of Clinical Pharmacy - September 5, 2017 Category: Drugs & Pharmacology Source Type: research