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Source: Neurocritical Care

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Total 235 results found since Jan 2013.

Reverse Locked-In Syndrome
ConclusionsSince the patient ’s deficits were the exact opposite of those described in locked-in syndrome, we propose the term “reverse locked-in syndrome” to describe this neurological entity characterized by bilateral ptosis, non-reactive pupils, and ophthalmoplegia with preservation of consciousness and extremity motor function.
Source: Neurocritical Care - July 25, 2017 Category: Neurology Source Type: research

Cerebellar Hippocampal and Basal Nuclei Transient Edema with Restricted diffusion (CHANTER) Syndrome
ConclusionsWe present findings of a potentially novel syndrome involving a distinct pattern of cerebellar and hippocampal restricted diffusion, with imaging and clinical characteristics distinct from ischemic stroke, hypoxic injury, and known toxidromes and leukoencephalopathies. Given the potential for favorable outcome despite early obstructive hydrocephalus, early identification and treatment of this syndrome are critical.
Source: Neurocritical Care - February 20, 2019 Category: Neurology Source Type: research

Common Data Elements for Subarachnoid Hemorrhage and Unruptured Intracranial Aneurysms: Recommendations from the Working Group on Subject Characteristics
ConclusionsThese CDEs would allow the development of best practice guidelines to standardize the assessment and reporting of observations concerning UIA and SAH.
Source: Neurocritical Care - May 9, 2019 Category: Neurology Source Type: research

Effect of Phenylephrine and Ephedrine on Cerebral (Tissue) Oxygen Saturation During Carotid Endarterectomy (PEPPER): A Randomized Controlled Trial
ConclusionsWithin this randomized prospective study, MAP correction by either phenylephrine or ephedrine showed to be equally effective in maintaining rSO2 in patients who underwent CEA.Clinical Trial Registration ClincalTrials.gov, NCT01451294.
Source: Neurocritical Care - June 11, 2019 Category: Neurology Source Type: research

Neurocritical Care Quality Improvement Practices: A Survey of Members of the Neurocritical Care Society
ConclusionA dedicated staffed NCCU QI program occurs in a minority of NCC units, and the lack of such programs may lead to clinician dissatisfaction. Institutional and departmental support may be critical elements of a successful and satisfactory implementation of NCCU QI.
Source: Neurocritical Care - October 14, 2019 Category: Neurology Source Type: research

Resource Allocation: Stable Patients Remain Stable 12 –24 h Post-tPA
ConclusionsNew onset of neurologic deterioration is rare 12 –24 h after treatment of acute stroke. Stable patients with low NIHSS scores and no ICU needs may not require intensive monitoring greater than 12 h post-treatment.
Source: Neurocritical Care - December 8, 2019 Category: Neurology Source Type: research

Predictors of Ventricular Dysrhythmias in Neurology Intensive Care Unit Patients with Prolonged QTc
ConclusionsIn this group of patients with prolonged QTc in the Neuro ICU, we observed several episodes of non-sustained ventricular tachycardia and identified important risk factors associated with their occurrence. This knowledge is essential to inform clinical decisions.
Source: Neurocritical Care - April 16, 2020 Category: Neurology Source Type: research

Safety and Feasibility of a Novel Transnasal Cooling Device to Induce Normothermia in Febrile Cerebrovascular Patients
ConclusionsInducing normothermia with a novel transnasal TMD appears to be safe, feasible and not associated with significant shivering. A multicenter trial testing the ability of the CoolStat to maintain normothermia for 24  h is currently underway.
Source: Neurocritical Care - July 13, 2020 Category: Neurology Source Type: research

The Neurological Examination Improves Cranial Accelerometry Large Vessel Occlusion Prediction Accuracy
ConclusionsCranial accelerometry models are improved by various additions of asymmetric arm weakness and the NIHSS. An exploratory analysis requiring asymmetric arm weakness prior to cranial accelerometry model training minimized false positives and negatives.
Source: Neurocritical Care - November 20, 2020 Category: Neurology Source Type: research

Clinicians ’ Perceptions of the Appropriateness of Neurocritical Care for Patients with Spontaneous Intracerebral Hemorrhage (ICH): A Qualitative Study
ConclusionsCaring for severely affected ICH patients in need of neurocritical care is challenging, particularly with frail elderly patients. Awareness of the challenges could facilitate interventions to improve decision-making for this group of stroke patients and their families, as well as measures to reduce the distress on clinicians who care for this patient group. Our findings highlight the need for effective interdisciplinary shared decision making involving the family, taking into account patients ’ previously expressed values and preferences and incorporating these into bespoke care planning.
Source: Neurocritical Care - December 2, 2020 Category: Neurology Source Type: research

COVID-19 and the Pediatric Nervous System: Global Collaboration to Meet a Global Need
AbstractThe coronavirus disease 2019 (COVID-19) pandemic has affected mortality and morbidity across all ages, including children. It is now known that neurological manifestations of COVID-19, ranging from headaches to stroke, may involve the central and/or peripheral nervous system at any age. Neurologic involvement is also noted in the multisystem inflammatory syndrome in children, a pediatric condition that occurs weeks after infection with the causative virus of COVID-19, severe acute respiratory syndrome coronavirus 2. Knowledge about mechanisms of neurologic disease is scarce but rapidly growing. COVID-19 neurologic ...
Source: Neurocritical Care - June 28, 2021 Category: Neurology Source Type: research

Role of Interleukin-1 Receptor-Like 1 (ST2) in Cerebrovascular Disease
AbstractFollowing both ischemic and hemorrhagic stroke, innate immune cells initiate a proinflammatory response that further exacerbate tissue injury in the acute phase, but these cells also play an important reparative role thereafter. Numerous cytokines and signaling pathways have been implicated in driving the deleterious proinflammatory response, but less is known about the mediators that connect the initial vascular injury to the systemic immune response and the relationship between proinflammatory and reparative immune responses. The Interleukin-33 (IL-33) and serum stimulation-2 (ST2) axis is an interleukin signalin...
Source: Neurocritical Care - July 6, 2021 Category: Neurology Source Type: research

Venous Injury in Patients with Blunt Traumatic Brain Injury: Retrospective Analysis of a National Cohort
ConclusionsWe identified a 0.3% incidence of CVI in all-comers with blunt TBI as well as several injury-related variables that may be used to guide investigation for dural venous sinus injury. CVI was associated with poorer outcomes, with superior sagittal sinus injury having the strongest association.
Source: Neurocritical Care - July 9, 2021 Category: Neurology Source Type: research

The Effect of Hyperoxemia on Neurological Outcomes of Adult Patients: A Systematic Review and Meta-Analysis
AbstractHyperoxemia commonly occurs in clinical practice and is often left untreated. Many studies have shown increased mortality in patients with hyperoxemia, but data on neurological outcome in these patients are conflicting, despite worsened neurological outcome found in preclinical studies. To investigate the association between hyperoxemia and neurological outcome in adult patients, we performed a systematic review and meta-analysis of observational studies. We searched MEDLINE, Embase, Scopus, Web of Science, Cumulative Index to Nursing and Allied Health Literature, and ClinicalTrials.gov from inception to May 2020 f...
Source: Neurocritical Care - January 31, 2022 Category: Neurology Source Type: research

Waveform Morphology as a Surrogate for ICP Monitoring: A Comparison Between an Invasive and a Noninvasive Method
ConclusionsThe new ICPni wave morphology monitor showed a good agreement with the standard invasive method and an acceptable discriminatory power to detect intracranial hypertension.Clinical trial registration Trial registration: NCT05121155.
Source: Neurocritical Care - March 24, 2022 Category: Neurology Source Type: research