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Source: International Immunopharmacology
Vaccination: Cancer Vaccines
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Total 74 results found since Jan 2013.
History of the discovery and development of Biomodulina T (InmunyVital ®), a useful immunomodulator with a broad range of clinical applications
This article identifies the milestones involved in the development of Biomodulina T. Since its discovery more than 35 years ago, reports show that Biomodulina T is a modulator of immune response and inflammation that is very useful for restoring the immune system in young and elderly people with immunodeficiencies, autoimmune diseases, and infections. Biomodulina T is also useful as an immunotherapeutic agent for improving immune responses in cancer and vaccines, for reversing immunosenescence and for improving healthspan in aging.PMID:37086680 | DOI:10.1016/j.intimp.2023.110167
Source: International Immunopharmacology - April 20, 2023 Category: Allergy & Immunology Authors: Roman R Rodriguez Martin Olivia Gonzalez Gonzalez Carolina Rodriguez Gonzalez Rene R Rodriguez Gonzalez Source Type: research
Thymosin α1 interacts with Galectin-1 modulating the β-galactosides affinity and inducing alteration in the biological activity
Int Immunopharmacol. 2023 Apr 5;118:110113. doi: 10.1016/j.intimp.2023.110113. Online ahead of print.ABSTRACTThe study of mechanism of action of Thymosin alpha 1 (Tα1) and the basis of the pleiotropic effect in health and disease, is one of the main focus of our ongoing research. Tα1 is a thymic peptide that demonstrates a peculiar ability to restore homeostasis in different physiological and pathological conditions (i.e., infections, cancer, immunodeficiency, vaccination, and aging) acting as multitasking protein depending on the host state of inflammation or immune dysfunction. However, few are the information about me...
Source: International Immunopharmacology - April 7, 2023 Category: Allergy & Immunology Authors: Claudia Matteucci Ridvan Nepravishta Ayele Argaw-Denboba Walter Mandaliti Alessandro Giovinazzo Vita Petrone Emanuela Balestrieri Paola Sinibaldi-Vallebona Francesca Pica Maurizio Paci Enrico Garaci Source Type: research
Thymosin alpha 1 - Reimagine its broader applications in the immuno-oncology era
Int Immunopharmacol. 2023 Mar 3;117:109952. doi: 10.1016/j.intimp.2023.109952. Online ahead of print.ABSTRACTThymosin alpha 1 (Tα1) is a highly conserved 28 amino-acid peptide naturally occurring in the thymus and plays critical roles in T cell maturity and differentiation. Its synthetic form, thymalfasin, has been approved by various regulatory agencies in the treatment of hepatitis B viral infection and as an enhancer of vaccine response in immune-compromised populations. In China, it has also widely utilized in patients with cancer and severe infections, as well as the emergency use during (Severe Acute Respiratory Syn...
Source: International Immunopharmacology - March 5, 2023 Category: Allergy & Immunology Authors: Li Mao Source Type: research
An insight overview on COVID-19 mRNA vaccines: Advantageous, pharmacology, mechanism of action, and prospective considerations
This study describes the structural features and technologies used in producing of COVID-19 mRNA-based vaccines as the most influential factor in controlling this pandemic and a successful pattern for planning to produce other kind of genetic vaccines against infections or cancers.PMID:36867924 | PMC:PMC9968612 | DOI:10.1016/j.intimp.2023.109934
Source: International Immunopharmacology - March 3, 2023 Category: Allergy & Immunology Authors: Mona Sadat Mirtaleb Reza Falak Jalal Heshmatnia Behnaz Bakhshandeh Ramezan Ali Taheri Hoorieh Soleimanjahi Reza Zolfaghari Emameh Source Type: research
Highlights into historical and current immune interventions for cancer
Int Immunopharmacol. 2023 Feb 27;117:109882. doi: 10.1016/j.intimp.2023.109882. Online ahead of print.ABSTRACTImmunotherapy is an additional pillar when combined with traditional standards of care such as chemotherapy, radiotherapy, and surgery for cancer patients. It has revolutionized cancer treatment and rejuvenated the field of tumor immunology. Several types of immunotherapies, including adoptive cellular therapy (ACT) and checkpoint inhibitors (CPIs), can induce durable clinical responses. However, their efficacies vary, and only subsets of cancer patients benefit from their use. In this review, we address three goal...
Source: International Immunopharmacology - February 27, 2023 Category: Allergy & Immunology Authors: Kathryn Cole Zaid Al-Kadhimi James E Talmadge Source Type: research
Nanovaccines for cancer immunotherapy: Focusing on complex formation between adjuvant and antigen
Int Immunopharmacol. 2023 Feb 23;117:109887. doi: 10.1016/j.intimp.2023.109887. Online ahead of print.ABSTRACTAs an interesting cancer immunotherapy approach, cancer vaccines have been developed to deliver tumor antigens and adjuvants to antigen-presenting cells (APCs). Although the safety and easy production shifted the vaccine designing platforms toward the subunit vaccines, their efficacy is limited due to inefficient vaccine delivery. Nanotechnology-based vaccines, called nanovaccines, address the delivery limitations through co-delivery of antigens and adjuvants into lymphoid organs and APCs and their intracellular re...
Source: International Immunopharmacology - February 25, 2023 Category: Allergy & Immunology Authors: Nasser Hashemi Goradel Mahnaz Nemati Azam Bakhshandeh Arash Arashkia Babak Negahdari Source Type: research
Antitumor effect of invasive Lactobacillus plantarum delivering associated antigen gene sHSP between Trichinella spiralis and Lewis lung cancer cells
In conclusion, the recombinant invasive Lactobacillus plantarum constructed in this study has better anti-Lewis lung cancer effects in mice, which will provide new ideas for the application of food-grade microorganisms in anti-tumor and the development of oral tumor vaccines.PMID:36638662 | DOI:10.1016/j.intimp.2023.109708
Source: International Immunopharmacology - January 13, 2023 Category: Allergy & Immunology Authors: Taotao Yue Xichen Zhang Pengtao Gong Jianhua Li Xiaocen Wang Xin Li Yeting Ma Xuejiao Chen Xu Zhang Shuqin Cheng Hongbo Zhang Nan Zhang Source Type: research
Nanovaccines in cancer immunotherapy: Focusing on dendritic cell targeting
Int Immunopharmacol. 2022 Nov 16;113(Pt B):109434. doi: 10.1016/j.intimp.2022.109434. Online ahead of print.ABSTRACTCancer immunotherapy is proposed to eradicate tumors by stimulating host anti-tumor immunity through utilizing various therapeutic approaches. Cancer vaccines have become a promising approach for cancer immunotherapy among the proposed platforms, either alone or in combination with other therapeutic agents. Due to the suboptimal efficacy of cancer vaccines in clinical trials and the advent of nanotechnology in the biomedicine field, scientists developed nanoplatforms, such as various nanoparticles (NPs), cell...
Source: International Immunopharmacology - November 19, 2022 Category: Allergy & Immunology Authors: Harun Achmad Yousif Saleh Ibrahim Muataz Mohammed Al-Taee Gamal A Gabr Muhammad Waheed Riaz Shadia Hamoud Alshahrani Andr és Alexis Ramírez-Coronel Abduladheem Turki Jalil Hendrik Setia Budi Windi Sawitri Malyutina Elena Stanislavovna Jitendra Gupta Source Type: research
Melanoma-derived exosomes: Versatile extracellular vesicles for diagnosis, metastasis, immune modulation, and treatment of melanoma
Int Immunopharmacol. 2022 Oct 20;113(Pt A):109320. doi: 10.1016/j.intimp.2022.109320. Online ahead of print.ABSTRACTMalignant melanoma is one of the most aggressive human neoplasms responsible for the majority of skin cancer-related deaths in its advanced stages. Achieving a thorough knowledge of reliable tumor-originated biomarkers and molecular mechanisms can provide many practical approaches and guide the way towards the design of rational curative therapies to improve the survival rate of patients. Cancer cells, including melanoma cells, release high amounts of a broad family of nanovesicles, containing different bioch...
Source: International Immunopharmacology - October 24, 2022 Category: Allergy & Immunology Authors: Seyedeh Alia Moosavian Maryam Hashemi Leila Etemad Sara Daneshmand Zahra Salmasi Source Type: research
