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Source: Infection, Genetics and Evolution
Vaccination: Malaria Vaccine
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Total 33 results found since Jan 2013.
Genetic diversity and molecular evolution of Plasmodium vivax Duffy Binding Protein and merozoite surface protein-1 in northwestern Thailand
This study aimed to use amplicon sequencing to investigate the genotypic patterns and population structure of P. vivax isolates from a highly endemic province of Thailand in recent years. Amplicon deep sequencing was performed on 70 samples for the 42-kDa region of pvmsp1 and domain II of pvdbp. Unique haplotypes were identified and a network constructed to illustrate genetic relatedness in northwestern Thailand. Based on this dataset of 70 samples collected between 2015 and 2021, 16 and 40 unique haplotypes were identified in pvdbpII and pvmsp142kDa, respectively. Nucleotide diversity was higher in pvmsp142kDa than in pvd...
Source: Infection, Genetics and Evolution - June 17, 2023 Category: Genetics & Stem Cells Authors: Parsakorn Tapaopong Gustavo da Silva Sittinont Chainarin Chayanut Suansomjit Khajohnpong Manopwisedjaroen Liwang Cui Cristian Koepfli Jetsumon Sattabongkot Wang Nguitragool Source Type: research
CRISPR/Cas advancements for genome editing, diagnosis, therapeutics, and vaccine development for Plasmodium parasites, and genetic engineering of Anopheles mosquito vector
Infect Genet Evol. 2023 Feb 24;109:105419. doi: 10.1016/j.meegid.2023.105419. Online ahead of print.ABSTRACTMalaria as vector-borne disease remains important health concern with over 200 million cases globally. Novel antimalarial medicines and more effective vaccines must be developed to eliminate and eradicate malaria. Appraisal of preceding genome editing approaches confirmed the CRISPR/Cas nuclease system as a novel proficient genome editing system and a tool for species-specific diagnosis, and drug resistance researches for Plasmodium species, and gene drive to control Anopheles population. CRISPR/Cas technology, as a ...
Source: Infection, Genetics and Evolution - February 26, 2023 Category: Genetics & Stem Cells Authors: Leila Nourani Akram Abouie Mehrizi Sakineh Pirahmadi Zeinab Pourhashem Elahe Asadollahi Babak Jahangiri Source Type: research
Genetic variations of Plasmodium falciparum circumsporozoite protein and the impact on interactions with human immunoproteins and malaria vaccine efficacy
This study examined polyclonal infections and the associations of parasite genetic variations with binding affinity to human leukocyte antigen (HLA). Multiplicity of infection was determined by amplicon deep sequencing of PfMSP1. Genetic variations in PfCSP were examined across 88 samples from Ghana and analyzed together with 1655 PfCSP sequences from other African and non-African isolates. Binding interactions of PfCSP peptide variants and HLA were predicted using NetChop and HADDOCK. High polyclonality was detected among infections, with each infection harboring multiple non-3D7 PfCSP variants. Twenty-seven PfCSP haploty...
Source: Infection, Genetics and Evolution - February 25, 2023 Category: Genetics & Stem Cells Authors: Cheikh Cambel Dieng Colby T Ford Anita Lerch Dickson Doniou Kovidh Vegesna Daniel Janies Liwang Cui Linda Amoah Yaw Afrane Eugenia Lo Source Type: research
Structural and genomic analysis of single nucleotide polymorphisms in human host factor endothelial protein C receptor (EPCR) reveals complex interplay with malaria parasites
Infect Genet Evol. 2023 Feb 10:105413. doi: 10.1016/j.meegid.2023.105413. Online ahead of print.ABSTRACTPlasmodium parasites responsible for malaria follow a complex life cycle of which half takes place inside the human host. Parasites present diverse antigens at different stages of their life cycle and interact with many surface molecules to attach to and enter host cells. The CIDRĪ±1 domain of Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) in infected erythrocytes adheres to one such vascular receptor endothelial protein C receptor (EPCR). EPCR is implicated in the pathogenesis of severe malaria as prefere...
Source: Infection, Genetics and Evolution - February 12, 2023 Category: Genetics & Stem Cells Authors: Jasmita Gill Amit Sharma Source Type: research
Detection of positive selection acting on protein surfaces at the whole-genome scale in the human malaria parasite Plasmodium falciparum
This study test hypothesizes that proteins subject to sequence evolution structural constraints play a crucial role and that these constraints hinder the modification of such proteins in this process. These hypotheses were tested using Plasmodium falciparum model and evaluated protein structures predicted for the entire proteome by the AlphaFold method. Based on dN/dS test results and P. falciparum and P. reichenowi comparisons, the presented approach identified proteins subject to purifying selection acting on the whole sequence and buried residues (dN < dS) and positive selection on nonburied residues. Of the 26 prote...
Source: Infection, Genetics and Evolution - December 26, 2022 Category: Genetics & Stem Cells Authors: Szymon Kaczanowski Source Type: research
