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Specialty: Genetics & Stem Cells
Source: Gene

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Total 68 results found since Jan 2013.

Single nucleotide polymorphism of CD40 in the 5'-untranslated region is associated with ischemic stroke.
CONCLUSIONS: The findings suggested that the CD40 -1C/T polymorphism might contribute to the susceptibility to ischemic stroke in the Chinese population, and might be associated with history of previous stroke. PMID: 23954880 [PubMed - as supplied by publisher]
Source: Gene - August 14, 2013 Category: Genetics & Stem Cells Authors: Ma Y, Wang SX, Liu Y, Peng GG, Wang XM, Zhang B, Wu BH, Yu JM Tags: Gene Source Type: research

Polymorphisms of TRIB1 Genes for Coronary Artery Disease and Stroke Risk: A Systematic Review and Meta-analysis
CONCLUSIONS: The rs2954029 A allele was significantly associated with an increased risk of CAD and stroke, according to the present meta-analysis. However, the association of rs17321515 polymorphism with susceptibility to CAD and stroke has not been found in this study.PMID:37414350 | DOI:10.1016/j.gene.2023.147613
Source: Gene - July 6, 2023 Category: Genetics & Stem Cells Authors: Jiangang Jiang Xinmin Chen Chengwei Li Xiaoma Du Huadong Zhou Source Type: research

The association between three promoter polymorphisms of IL-1 and stroke: A meta-analysis.
CONCLUSION: In conclusion, our results suggested that IL-1α-889C/T polymorphism is associated with stroke risk, especially in Asians. However, no associations of IL-1β-511C/T and IL-RN polymorphisms on stroke risk in overall analysis or subgroup analysis. PMID: 25917615 [PubMed - as supplied by publisher]
Source: Gene - April 23, 2015 Category: Genetics & Stem Cells Authors: Zou L, Zhao H, Gong X, Jiang A, Guan S, Wang L, Zheng S Tags: Gene Source Type: research

ALA16VAL-MnSOD gene polymorphism and stroke: Association with dyslipidemia and glucose levels.
Abstract Stroke risk has been associated to the progression of carotid plaques due to high glucose levels and lipid accumulation, which are greatly associated to cerebral injury, brain oxidative stress, and apoptosis. The ALA16VAL-MnSOD gene single nucleotide polymorphism (SNP) has shown to modulate risk factors of several metabolic and vascular diseases, such as blood glucose (GLU) and lipid levels. However, the association of these factors in stroke patients has not been studied to date. Thus, we evaluated the influence of the Ala16Val-MnSOD SNP on lipid profile, GLU levels, oxidative and DNA damage of 44 patien...
Source: Gene - May 25, 2017 Category: Genetics & Stem Cells Authors: Flores AE, Pascotini ET, Kegler A, Gabbi P, Bochi GV, Barbisan F, Duarte T, Prado ALC, Duarte MMMF, da Cruz IBM, Moresco RN, Santos ARS, Bresciani G, Royes LFF, Fighera MR Tags: Gene Source Type: research

Chromosome 10q25 polymorphism is associated with susceptibility to large artery atherosclerotic stroke.
CONCLUSIONS: In the southeastern Chinese population, the rs11196288A > G polymorphism is associated with decreased risk of LAA stroke. PMID: 30580071 [PubMed - as supplied by publisher]
Source: Gene - December 20, 2018 Category: Genetics & Stem Cells Authors: Gu M, Wang M, Cai B, Cheng X, Li Z, Sun B, Wang F, Shi Y, Zhang Z, Liu X Tags: Gene Source Type: research

Genetic variants in ALDH2 predict risk of ischemic stroke in a Chinese population.
CONCLUSIONS: Genetic polymorphisms in ALDH2 modified ischemic stroke risk and outcome in Chinese males, but not in females. PMID: 30077765 [PubMed - as supplied by publisher]
Source: Gene - August 2, 2018 Category: Genetics & Stem Cells Authors: Cheng X, Xu J, Gu M, Wang M, Sun B, Li Z, Ni G, Wang G, Weng Z, Shi Y, Zhang Z, Liu X Tags: Gene Source Type: research

Gene polymorphisms of angiotensin-converting enzyme and angiotensinogen and risk of idiopathic ischemic stroke.
CONCLUSIONS: The M235T and T174M polymorphisms represented an increased risk for stroke in young Mexican individuals. In contrast, the I/D was not associated with in the same group of patients. The AGT levels were higher in the acute phase of stroke, but it was not determined by the polymorphisms. PMID: 30521887 [PubMed - as supplied by publisher]
Source: Gene - December 3, 2018 Category: Genetics & Stem Cells Authors: Isordia-Salas I, Santiago-Germán D, Cerda-Mancillas MC, Hernández-Juárez J, Bernabé-García M, Leaños-Miranda A, Alvarado-Moreno JA, Majluf-Cruz A Tags: Gene Source Type: research

TNFRSF11B polymorphisms predict poor outcome after large artery atherosclerosis stroke.
This study aimed to determine whether TNFRSF11B polymorphisms are associated with prognosis of large artery atherosclerosis (LAA) stroke. Three TNFRSF11B polymorphisms (rs2073617, rs2073618 and rs3134069) were genotyped in 1,010 patients with LAA stroke. Short-term outcome was evaluated using the modified Rankin Scale score at 3-month after stroke onset. Long-term outcome was assessed using the stroke recurrence. We found that rs2073617G was associated with an increased risk of poor outcome of LAA stroke (additive model: odds ratio (OR) = 1.35, 95% confidence interval (CI) = 1.06-1.73). This association was also observed i...
Source: Gene - March 24, 2020 Category: Genetics & Stem Cells Authors: Wang M, Gu M, Li Z, Lian X, Shen H, Dai Z, Zhang Z, Liu X Tags: Gene Source Type: research

Worst spasticity in patients post-stroke associated with mnsod ala16val polymorphism and interleukin-1 β
Gene. 2022 Sep 10:146880. doi: 10.1016/j.gene.2022.146880. Online ahead of print.ABSTRACTThe MnSOD Ala16Val single nucleotide polymorphism (SNP) has shown to be associated to risk factors of several metabolic and vascular diseases. However, little is known about interaction between MnSOD Ala16Val SNP in stroke, a frequent neurologic disease that involves clinic manifestations such as motor deficits and spasticity. In this sense, we decided to investigate the relationship between MnSOD Ala16Val SNP with spasticity in stroke and also its influence on interleukin levels, BDNF, and glycolipid parameters. Eighty post-stroke sub...
Source: Gene - September 13, 2022 Category: Genetics & Stem Cells Authors: Ariane Ethur Flores Eduardo Tanuri Pascotini Aline Kegler N úbia Broetto Patricia Gabbi Thiago Duarte Ana Lucia Cervi Prado Marta M M F Duarte Ivana B M da Cruz Adair Roberto Soares Dos Santos Luiz Fernando Freire Royes Michele Rechia Fighera Source Type: research

Genetic determinants in ischaemic stroke subtypes: Seven year findings and a review.
Abstract Stroke is a global health problem and a leading cause of disability worldwide. There have been numerable studies undertaking research on different aspects of ischaemic stroke employing various epidemiological, clinical and molecular parameters. Nevertheless ischaemic stroke being a complex disorder with different subtypes demands equal attention towards its subtypes too. Since there has been enough evidence that disposition to certain subtype is genetically determined and there is a distinct mechanism that influences its development, association studies should focus on subtypes simultaneously while studyi...
Source: Gene - November 12, 2014 Category: Genetics & Stem Cells Authors: Munshi A, Das S, Kaul S Tags: Gene Source Type: research

Mechanistic and therapeutic role of Drp1 in the pathogenesis of Stroke
Gene. 2022 Dec 18:147130. doi: 10.1016/j.gene.2022.147130. Online ahead of print.ABSTRACTStroke had emerged as one of the leading causes of death and long-term disability across the globe. Emerging evidence suggests a significant increase in the incidence of stroke with age, which is further expected to increase dramatically owing to an ever-expanding elderly population. The current situation imposes a significant burden on the healthcare system and requires a deeper understanding of the underlying mechanisms and development of novel interventions. It is well established that mitochondrial dysfunction plays a pivotal role ...
Source: Gene - December 21, 2022 Category: Genetics & Stem Cells Authors: Himaja Pegadraju Joshua Abby Thomas Rahul Kumar Source Type: research

Impacts of COX-1 gene polymorphisms on vascular outcomes in patients with ischemic stroke and treated with aspirin.
In conclusion, in Chinese patients with ischemic stroke and treated with aspirin, CC genotype of rs1330344 may increase the risk of subsequent vascular events. PMID: 24930730 [PubMed - as supplied by publisher]
Source: Gene - June 12, 2014 Category: Genetics & Stem Cells Authors: Cao L, Zhang Z, Sun W, Bai W, Sun W, Zhang Y, Wang X, Cai B, Xie X, Duan Z, Cai Q, Liu D, Xiong Y, Ma M, Liu X, Xu G Tags: Gene Source Type: research

Are ALOX5AP gene SNPs a risk or protective factor for Stroke?
Abstract ALOX5AP (5-lipoxygenase) has been recognized as a susceptibility gene for stroke. Using a case-control design, the whole coding and adjoining intronic regions of ALOX5AP was sequenced to study the role of SNPs and their interplay with other risk factors in Greek patients with stroke. Patients (n=213) were classified by the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Their mean age of was 58.9±14.64, comprising 145 males. The control group consisted of 210 subjects, ethnicity, sex and age matched, with no stroke history. Risk factors (hyperlipidemia, hypertension, atrial fibrillation, migraine, ...
Source: Gene - July 7, 2014 Category: Genetics & Stem Cells Authors: Papapostolou A, Spengos K, Fylaktou I, Poulou M, Gountas I, Kitsiou-Tzeli S, Kanavakis E, Tzetis M Tags: Gene Source Type: research

Ctnnb1 transcriptional upregulation compensates for Mdm2/p53-mediated β-catenin degradation in neutrophils following cardioembolic stroke.
CONCLUSION: Compensatory Ctnnb1 transcriptional upregulation in neutrophils induced by ischemic neuron exposure may be involved in promoting neutrophil survival following cardioembolic stroke. PMID: 32758579 [PubMed - as supplied by publisher]
Source: Gene - August 2, 2020 Category: Genetics & Stem Cells Authors: Wang H, Zhou K, Li W, Du J, Xiao J Tags: Gene Source Type: research