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Specialty: Biology
Source: Free Radical Biology and Medicine
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Total 77 results found since Jan 2013.
Properties and reactivity of the folic acid and folate photoproduct 6-formylpterin
Free Radic Biol Med. 2021 May 6:S0891-5849(21)00283-5. doi: 10.1016/j.freeradbiomed.2021.05.002. Online ahead of print.ABSTRACTFolates (vitamin B9) are essential components of our diet and our gut microbiota. They are omnipresent in our cells and blood. Folates are necessary for DNA synthesis, methylation, and other vital bioprocesses. Folic acid (FA), as the synthetic form of folates, is largely found in supplements and fortified foods. FA and folate drugs are also extensively used as therapeutics. Therefore, we are continuously exposed to the pterin derivatives, and their photo-degradation products, such as 6-formylpteri...
Source: Free Radical Biology and Medicine - May 9, 2021 Category: Biology Authors: Goossens Jean-Fran çois Xavier Thuru Christian Bailly Source Type: research
Breaking barriers: Neurodegenerative repercussions of radiotherapy induced damage on the blood-brain and blood-tumor barrier
Free Radic Biol Med. 2021 Dec 4:S0891-5849(21)00853-4. doi: 10.1016/j.freeradbiomed.2021.12.002. Online ahead of print.ABSTRACTExposure to radiation during the treatment of CNS tumors leads to detrimental damage of the blood brain barrier (BBB) in normal tissue. Effects are characterized by leakage of the vasculature which exposes the brain to a host of neurotoxic agents potentially leading to white matter necrosis, parenchymal calcification, and an increase chance of stroke. Vasculature of the blood tumor barrier (BTB) is irregular leading to poorly perfused and hypoxic tissue throughout the tumor that becomes resistant t...
Source: Free Radical Biology and Medicine - December 7, 2021 Category: Biology Authors: Barrett D Allen Charles L Limoli Source Type: research
Good, bad, and neglectful: Astrocyte changes in neurodegenerative disease
Free Radic Biol Med. 2022 Feb 21:S0891-5849(22)00073-9. doi: 10.1016/j.freeradbiomed.2022.02.020. Online ahead of print.ABSTRACTAstrocytes play key roles in CNS development as well as well as neuro-supportive roles in the mature brain including ionic, bioenergetic and redox homeostasis. Astrocytes undergo rapid changes following acute CNS insults such as stroke or traumatic brain injury, but are also profoundly altered in chronic neurodegenerative conditions such as Alzheimer's disease. While disease-altered astrocytes are often referred to as reactive, this does not represent a single cellular state or group of states, bu...
Source: Free Radical Biology and Medicine - February 24, 2022 Category: Biology Authors: Zoeb Jiwaji Giles E Hardingham Source Type: research
The role of glutathione peroxidase-1 in health and disease
Free Radic Biol Med. 2022 Jun 9:S0891-5849(22)00224-6. doi: 10.1016/j.freeradbiomed.2022.06.004. Online ahead of print.ABSTRACTGlutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is found in the cytoplasm and mitochondria of mammalian cells. Like most selenoenzymes, it has a single redox-sensitive selenocysteine amino acid that is important for the enzymatic reduction of hydrogen peroxide and soluble lipid hydroperoxides. Glutathione provides the source of reducing equivalents for its function. As an antioxidant enzyme, GPx1 modulates the balance between necessary and harmful levels of reactive...
Source: Free Radical Biology and Medicine - June 12, 2022 Category: Biology Authors: Diane E Handy Joseph Loscalzo Source Type: research
Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease
Free Radic Biol Med. 2022 Nov 14:S0891-5849(22)00983-2. doi: 10.1016/j.freeradbiomed.2022.11.020. Online ahead of print.ABSTRACTOxidative stress generating DNA damage has been shown to be a key characteristic in Alzheimer's disease (AD). However, how it affects the pathogenesis of AD is not yet fully understood. Neil3 is a DNA glycosylase initiating repair of oxidative DNA base lesions and with a distinct expression pattern in proliferating cells. In brain, its function has been linked to hippocampal-dependent memory and to induction of neurogenesis after stroke and in prion disease. Here, we generated a novel AD mouse mod...
Source: Free Radical Biology and Medicine - November 17, 2022 Category: Biology Authors: Milena A Egiazarian Silje Str ømstad Teri Sakshaug Ana B Nunez-Nescolarde Nicole Bethge Magnar Bj ørås Katja Scheffler Source Type: research
Taurine attenuates neuronal ferroptosis by regulating GABA < sub > B < /sub > /AKT/GSK3 β/β-catenin pathway after subarachnoid hemorrhage
Free Radic Biol Med. 2022 Nov 16:S0891-5849(22)00965-0. doi: 10.1016/j.freeradbiomed.2022.11.003. Online ahead of print.ABSTRACTFerroptosis, characterized by lipid peroxidation and intracellular iron accumulation, has been reported to be involving in the pathophysiological of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Although taurine reportedly yields neuroprotective effects in multiple central neurological diseases and can attenuated neuron damage after stroke, its role in EBI after SAH remains unclear. The present study indicated that taurine levels in cerebrospinal fluid were significantly reduced in...
Source: Free Radical Biology and Medicine - November 19, 2022 Category: Biology Authors: Chengli Liu Peibang He Yujia Guo Qi Tian Jianfeng Wang Guijun Wang Zhan Zhang Mingchang Li Source Type: research
Altered trafficking of miRNAs at mitochondria modulates mitochondrial functions and cell death in brain ischemia
Free Radic Biol Med. 2023 Feb 11:S0891-5849(23)00053-9. doi: 10.1016/j.freeradbiomed.2023.02.004. Online ahead of print.ABSTRACTStroke is one of the major causes of death and disabilities worldwide. The rapid induction of cell death by necrosis and apoptosis is observed at the ischemic core, while long lasting apoptosis and brain inflammation continue in the penumbra. The emerging evidence suggests a critical role of mitochondria in acute and chronic inflammation and cell death. Mitochondrial dysfunction may result in the release of mitokines and/or mitochondrial DNA into the cytoplasm and activate multiple cytosolic pathw...
Source: Free Radical Biology and Medicine - February 13, 2023 Category: Biology Authors: Dhruv Gohel Shatakshi Shukla Wenson David Rajan Bartosz Wojtas Bozena Kaminska Rajesh Singh Source Type: research
