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Source: Experimental Neurology
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Total 393 results found since Jan 2013.
Changes of cerebral network activity after invasive stimulation of the mesencephalic locomotor region in a rat stroke model
Exp Neurol. 2021 Oct 5:113884. doi: 10.1016/j.expneurol.2021.113884. Online ahead of print.ABSTRACTMotor deficits after stroke reflect both, focal lesion and network alterations in brain regions distant from infarction. This remote network dysfunction may be caused by aberrant signals from cortical motor regions travelling via mesencephalic locomotor region (MLR) to other locomotor circuits. A method for modulating disturbed network activity is deep brain stimulation. Recently, we have shown that high frequency stimulation (HFS) of the MLR in rats has restored gait impairment after photothrombotic stroke (PTS). However, it...
Source: Experimental Neurology - October 8, 2021 Category: Neurology Authors: Stefanie D Kr ämer Michael K Schuhmann Fabian Schadt Ina Israel Samuel Samnick Jens Volkmann Felix Fluri Source Type: research
Post-acute delivery of α5-GABAA antagonist, S 44819, improves functional recovery in juvenile rats following stroke
Exp Neurol. 2021 Sep 28:113881. doi: 10.1016/j.expneurol.2021.113881. Online ahead of print.ABSTRACTHypo-excitability was reported in the peri-infarct tissue following stroke, an effect counteracted by a blockage of α5-GABAA receptors in adult rodents. Our present study aims to evaluate the effect of a selective α5-GABAA receptor antagonist, S 44819, in stroke in juvenile animals. We have set up and characterized an original model of transient ischemic stroke in 28 day-old Sprague-Dawley rats (45-min occlusion of the middle cerebral artery by intraluminal suture). In this model, S 44819 (1, 3 and 10 mg/kg, b.i.d) was ora...
Source: Experimental Neurology - October 1, 2021 Category: Neurology Authors: Florent Lebrun Nicolas Violle Annelise Letourneur Christophe Muller Nicolas Fischer Anthony Levilly Cyrille Orset Aurore Sors Denis Vivien Source Type: research
Sigma-1 receptor activation alleviates blood-brain barrier disruption post cerebral ischemia stroke by stimulating the GDNF-GFR α1-RET pathway
In this study, we investigated Sig-1R activation as a BBB integrity promoter via many post ischemic stroke pathways. Sig-1R activation in BBB-associated astrocytes can increase glia-derived neurotrophic factor (GDNF) secretion in bilateral common carotid artery occlusion (BCCAO) mice. Upregulated GDNF activates its receptors in CMECs to promote BBB integrity, and activated Sig-1R in CMECs facilitates this process. In vitro experiments have found that Sig-1R activation in CMECs promotes the interaction between the GDNF α1 receptor and transduction rearrangement gene, increasing PI3K-AKT-junction protein signaling pathway e...
Source: Experimental Neurology - September 28, 2021 Category: Neurology Authors: Danyang Liu Luxi Yang Peng Liu Xuefei Ji Xiaoxiao Qi Ziqi Wang Tianyang Chi Libo Zou Source Type: research
Hypoxic postconditioning promotes neurogenesis by modulating the metabolism of neural stem cells after cerebral ischemia
In conclusion, cerebral ischemia modulated the FAO and glycolysis of neural stem cells. HPC promoted the proliferation and migration of neural stem cells after MCAO, and these effects may be related to the regulation of metabolism, including FAO and glycolysis.PMID:34563509 | DOI:10.1016/j.expneurol.2021.113871
Source: Experimental Neurology - September 26, 2021 Category: Neurology Authors: Haiyan Li Sijie Li Changhong Ren Chen Gao Ning Li Chunxiu Wang Lin Wang Wenbo Zhao Xunming Ji Kunlin Jin Source Type: research
Ephrin-B2 PB-mononuclear cells reduce early post-stroke deficit in diabetic mice but not long-term memory impairment
CONCLUSIONS: Intravenous PB-MNC+ administration the day after stroke induction in diabetic mice improved sensorimotor deficit and reduced infarct volume at the short term, but was unable to prevent long-term memory loss. To what extent diabetes impacts on cell therapy efficacy will have to be specifically investigated in the future. Including vascular risk factors systematically in preclinical studies of cell therapy will provide a comprehensive understanding of the mechanisms potentially limiting cell efficacy and also to identify good and bad responders, particularly in the long term.PMID:34520725 | DOI:10.1016/j.expneurol.2021.113864
Source: Experimental Neurology - September 14, 2021 Category: Neurology Authors: Adrien Cogo Gabrielle Mangin Sarah Mouazan Tatiana Merkulova-Rainon Jean-Pierre Riveline Jean-Fran çois Gautier Mathilde Varret Nathalie Kubis Source Type: research
Nitro-oleic acid-mediated blood-brain barrier protection reduces ischemic brain injury
In conclusion, OA-NO2 preserves BBB integrity and confers neurovascular protection in ischemic brain damage. OA-NO2-mediated brain protection may help us to develop a novel therapeutic strategy for the treatment of ischemic stroke.PMID:34499902 | DOI:10.1016/j.expneurol.2021.113861
Source: Experimental Neurology - September 9, 2021 Category: Neurology Authors: Chao Zhou Moxi Su Ping Sun Xuelian Tang Ke-Jie Yin Source Type: research
